Your cart is currently empty!
Cincinnati Reds vs St. Louis Cardinals Prediction 9/17/2025 Today’s MLB Picks
Pick details
Cincinnati (75-76) vs St. Louis (74-78)
September 17, 2025 at 01:15 PM EDT
The Line: Betting Odds: St. Louis -108 / Reds -113 — Over/Under: 8.5
The Cincinnati Reds and St. Louis Cardinals meet on Wednesday in MLB action from the Busch Stadium. Here’s a Cincinnati Reds vs St. Louis Cardinals prediction. We will look at this from a betting perspective and determine the best Cardinals vs Reds pick. We will examine:
The St. Louis Cardinals’ recent form and player performance
The Cincinnati Reds’ recent form and player performance
Recent betting trends and streaks involving the Reds
Recent betting trends and streaks involving the Cardinals
Recent betting trends in games played between the Reds and Cardinals
A summary that ties it all together and produces a favorable betting outcome for the Reds and Cardinals game.
The Reds on Tuesday faced off against the Cardinals, and the offense was awful. They finished with three hits total, but zero runs and that led to the defeat. Andrew Abbott was on the mound and he went 4.2 innings giving up eight hits and three runs. He had seven strikeouts and zero walks. His outing wasn’t awful, but the team just refused to give him any sort of run support, and they have to get the offense going here.
The Reds are averaging 4.5 runs while their pitching is giving up 4.43 per game. The offense is ranked 13th while the pitching is ranked 15th in the league. Opponents are only batting .237 as a team against them, which is 8th. Getting the start for the Reds will be Brady Singer, who sits with a 13-10 record and an ERA of 3.94. Against the A’s, he went six innings, giving up three hits and two runs.
The Cardinals are averaging 4.29 runs while their pitching is giving up 4.69 runs per game. The offense is ranked 18th while the pitching is ranked 21st. The stats for this team haven’t been great, and it’s something they need to quickly improve on to end the season. Wilson Contreras has hit 20 home runs and driven in 80 RBIs. Andre Pallante sits with a 6-14 record and an ERA of 5.34. Against the Milwaukee Brewers in his last start, he went five innings giving up three hits and five runs.
I am just not sold on the Cardinals pitcher in this game, and that is going to be the difference. Pallante sits with an ERA of 5.34 and he’s going to be awful again here. His last start was a decent start and he still gave up five runs. The Reds are averaging 4.5 runs per game and they are going to have no issue running up the score here. Singer will also have another dominant start, and that is going to be enough here as the Reds will end up coming out ahead. Back the Reds on the money line.
The St. Louis Cardinals’ recent form and player performance
The Cincinnati Reds’ recent form and player performance
Recent betting trends and streaks involving the Reds
Recent betting trends and streaks involving the Cardinals
Recent betting trends in games played between the Reds and Cardinals
A summary that ties it all together and produces a favorable betting outcome for the Reds and Cardinals game.
Can the Reds Bounce Back?
The Reds on Tuesday faced off against the Cardinals, and the offense was awful. They finished with three hits total, but zero runs and that led to the defeat. Andrew Abbott was on the mound and he went 4.2 innings giving up eight hits and three runs. He had seven strikeouts and zero walks. His outing wasn’t awful, but the team just refused to give him any sort of run support, and they have to get the offense going here.
The Reds are averaging 4.5 runs while their pitching is giving up 4.43 per game. The offense is ranked 13th while the pitching is ranked 15th in the league. Opponents are only batting .237 as a team against them, which is 8th. Getting the start for the Reds will be Brady Singer, who sits with a 13-10 record and an ERA of 3.94. Against the A’s, he went six innings, giving up three hits and two runs.
Solid Win for the Cardinals
It was a solid win for the Cardinals on Tuesday, and they were able to pick up the 3-0 victory. Thomas Saggese had a huge game hitting a home run and driving in two RBIs. On the mound for Michael McGreevy and he went seven innings giving up three hits and zero runs. He had six strikeouts and three walks.
The Cardinals are averaging 4.29 runs while their pitching is giving up 4.69 runs per game. The offense is ranked 18th while the pitching is ranked 21st. The stats for this team haven’t been great, and it’s something they need to quickly improve on to end the season. Wilson Contreras has hit 20 home runs and driven in 80 RBIs. Andre Pallante sits with a 6-14 record and an ERA of 5.34. Against the Milwaukee Brewers in his last start, he went five innings giving up three hits and five runs.
Cincinnati Reds vs St. Louis Cardinals Prediction
I am just not sold on the Cardinals pitcher in this game, and that is going to be the difference. Pallante sits with an ERA of 5.34 and he’s going to be awful again here. His last start was a decent start and he still gave up five runs. The Reds are averaging 4.5 runs per game and they are going to have no issue running up the score here. Singer will also have another dominant start, and that is going to be enough here as the Reds will end up coming out ahead. Back the Reds on the money line.
