Cincinnati Reds vs Milwaukee Brewers Prediction 9/26/2025 Today’s MLB Picks

The Cincinnati Reds and the Milwaukee Brewers meet Friday in MLB action from American Family Field. We will look at this from a betting perspective and determine the best bets for this game. Here’s a Cincinnati Reds vs. Milwaukee Brewers prediction.

Starting Pitching Matchup

The Cincinnati Reds will send out Zack Littell for the start here and Littell is 10-8 with a 3.86 ERA and 127 strikeouts this season. In his career, Littell is 0-0 with a 2.25 ERA and 8 strikeouts against the Brewers. Quinn Priester will start here for the Brewers and Priester is 13-2 with a 2.25 ERA and 128 strikeouts this season. In his career, Priester is 0-0 with a 3.18 ERA and 9 strikeouts against Cincinnati.

Cincinnati Reds Recap

The Cincinnati Reds come into this game looking to build on their 2-1 win over the Pittsburgh Pirates last time out to sit at 81-78 this season.

Reds Trying To Keep Playoff Hopes Alive

Elly De La Cruz has 163 hits with 21 home runs, 5 RBIs, 31 doubles and 36 stolen bases while TJ Friedl has 147 hits with 21 doubles, 13 home runs and 50 RBIs with 12 stolen bases. Gavin Lux has added 117 hits with 26 doubles and 53 RBIs while Spencer Steer has 21 home runs and 74 RBIs and Matt McLain has added 15 homers, 49 RBIs and 18 stolen bases as well on the year. Jose Trevino’s also chipped in 20 doubles as well this season.

Milwaukee Brewers Recap

The Milwaukee Brewers come into this game looking to add on to their 3-1 win over the San Diego Padres last time out to sit at 96-63 this season.

Brewers Snap Three-Game Skid

Brice Turang has 165 hits with 18 home runs, 78 RBIs and 24 stolen bases while Jackson Chourio has 145 hits with a team-high 34 doubles, 19 stolen bases, 20 home runs and 77 RBIs and Sal Frelick has 151 hits as well as 3 triples, 12 home runs, 63 RBIs and 19 stolen bases so far this season. Christian Yelich also has 16 stolen bases with 29 homers and 102 RBIs while also adding 20 doubles. Yelich also has a team-high 162 strikeouts up to this point in the year. William Contreras has 17 homers and 76 RBIs as well this season. Joey Ortiz has chipped in 107 hits with 17 doubles, 7 home runs and 45 RBIs and Caleb Durbin also has 25 doubles with 11 homers and 53 RBIs. 

Cincinnati Reds @ Milwaukee Brewers Betting Trends: September 26, 2025

• Probable Starting Pitcher: Quinn Priester      Record this season: 13-2      ERA: 3.25
• Home Record: 7-1
• Last 5 against Reds: 1-0

Why the Milwaukee Brewers will win

• The Brewers have won each of their last nine night games against National League opponents following a road win.
• The Reds have lost 13 of their last 14 games against the Brewers following a win.
• The Reds have failed to cover the run line in each of their last four games.
• The Brewers have covered the run line in each of their last three home games.
• The Reds have trailed after 3 innings in each of their last six Friday night games as road underdogs.
• The Brewers have led after 5 innings in six of their last seven night games at American Family Field against NL Central opponents.

• Probable Starting Pitcher: Zack Littell      Record this season: 10-8      ERA: 3.86
• Road Record: 7-4
• Last 5 against Brewers: 0-0

Why the Cincinnati Reds will win

• The underdogs have won each of the Brewers’ last four games.
• The Brewers have lost five of their last six games as favorites against National League opponents.
• The Brewers have failed to cover the run line in each of their last seven games as favorites against National League opponents.
• The Reds have covered the run line in each of their last seven games as underdogs against National League opponents.
• The Brewers have trailed after 5 innings in each of their last five games against NL Central opponents.
• The Brewers have lost the first inning in four of their last five night games against National League opponents.
• The Brewers have trailed after 3 innings in four of their last five games against NL Central opponents.

Total Runs Facts

• Each of the Reds’ last five games as underdogs against NL Central opponents have gone OVER the total runs line.
• Each of the Brewers’ last four games as favorites against the Reds have gone OVER the total runs line.
• The ‘Inning 1 UNDER 0.5 runs’ market has hit in each of the Reds’ last five games.
• The ‘Inning 1 UNDER 0.5 runs’ market has hit in five of the last six games between the Reds and Brewers at American Family Field.

Milwaukee Brewers Player Prop Facts

• Christian Yelich has hit at least one home run in four of his last five appearances after not playing the previous day.
• Andrew Vaughn has recorded a Double in each of his last four appearances after not playing the previous day.
• Sal Frelick has recorded at least one hit in each of his last 12 appearances against NL Central opponents.

Cincinnati Reds Player Prop Facts

• Spencer Steer has hit at least one home run in three of his last four appearances with the Reds as underdogs against NL Central opponents.
• Austin Hays has recorded at least one hit in each of the Reds’ last 10 games as underdogs.
• Jose Trevino has recorded a Double in each of his last three road appearances against NL Central opponents that held a winning record.
• Elly De La Cruz ranks T6th in the league in Steals (36) this season.

Matchup/League Facts

• The Brewers rank 1st in the league for on-base percentage this season (.333).
• The Brewers rank 2nd in the league for steals this season (161).
• The Reds rank 7th in the league for opponent batting average this season (.234).
• The Reds rank 7th in the league for hits allowed this season (1243).

Cincinnati Reds vs. Milwaukee Brewers Prediction

I’m on the Brewers here. It’s the Reds with everything to lose in this series as they’re still fighting for their season while the Brewers have clinched home field and the best record in the National League. However, I think it’s telling that the Brewers moved Priester in for this series, who has been one of their best starters this entire year. They’re taking this series seriously and are interested in the role of spoiler. The Brewers have won 19 straight appearances by Priester, while Littell for me was still a head scratching acquisition made by the Reds. I think the Brewers pick up the win here. Give me Milwaukee.