Cincinnati Reds vs Arizona Diamondbacks Prediction 8/21/2026 Today’s MLB Picks

In this article, we will formulate a Reds vs Diamondbacks Prediction for this MLB matchup on Friday, August 21st in the opening game of this series. Let’s take a look at the prediction for this MLB matchup.

Arizona Diamondbacks Preview

The Arizona Diamondbacks have a 67-61 record this season and are sitting in 3rd place in the NL West. They have a 36-27 home record and are coming off a 7-6 road win against the Red Sox. They will face the Cubs and the Giants next.

The Arizona Diamondbacks have a .243 batting average this season, a .316 OBP, and a .398 slugging percentage. The Diamondbacks’ pitching staff has a 4.18 ERA and a 1.29 WHIP. Gabriel Moreno leads the Diamondbacks with a .307 batting average. Ketel Marte leads the team in RBI with 67 and adds a team-high 21 home runs.

Eduardo Rodriguez (L) is the projected starting pitcher for the Diamondbacks, and he has a 12-4 record, a 2.71 ERA, and a 1.21 WHIP.

Cincinnati Reds Preview

The Cincinnati Reds have a 61-67 record this season and are sitting in 5th place in the NL Central. They have a 29-31 road record and are coming off a 9-10 home loss against the Cardinals. They will face the Giants and the Cubs next.

The Cincinnati Reds have a .226 batting average this season, a .305 OBP, and a .391 slugging percentage. The Reds’ pitching staff has a 4.48 ERA and a 1.40 WHIP. Elly De La Cruz leads the Reds with a .259 batting average. Sal Stewart leads the team in RBI with 96 and adds a team-high 27 home runs.

Nick Lodolo (L) is the projected starting pitcher for the Reds, and he has a 3-2 record, a 4.52 ERA, and a 1.42 WHIP.

Cincinnati Reds @ Arizona Diamondbacks Betting Trends: August 21, 2026

• Probable Starting Pitcher: Eduardo Rodriguez      Record this season: 12-4      ERA: 2.71
• Home Record: 6-3
• Last 5 against Reds: 1-1

Why the Arizona Diamondbacks will win

• The Diamondbacks have won seven of their last eight games against the Reds after going to extra innings.
• The Reds have lost four of their last five road games against National League opponents.
• The Diamondbacks have covered the run line in each of their last eight games against National League opponents after going to extra innings.
• The Reds have failed to cover the run line in seven of their last eight night games against National League opponents.
• The Reds have trailed after 3 innings in each of their last eight games at Chase Field.
• The Diamondbacks have won the first inning in each of their last four home games.
• The Reds have trailed after 5 innings in each of their last six road night games.

• Probable Starting Pitcher: Nick Lodolo      Record this season: 3-2      ERA: 4.52
• Road Record: 1-0
• Last 5 against Diamondbacks: 0-0

Why the Cincinnati Reds will win

• The Reds have won each of their last seven night games following a home loss.
• The Diamondbacks have lost five of their last six games as favorites against NL Central opponents following a road win.
• The underdogs have covered the run line in 13 of the last 14 games between the Reds and Diamondbacks.
• The Diamondbacks have failed to cover the run line in each of their last six games as favorites against the Reds following a win.
• The Reds have won the first inning in three of their last four games against NL West opponents.
• The Diamondbacks have trailed after 5 innings in four of their last five games against NL Central opponents that held a losing record.
• The Diamondbacks have trailed after 3 innings in each of their last four games.

Total Runs Facts

• Seven of the Reds’ last eight road games against NL West opponents have gone OVER the total runs line.
• Each of the last four games between the Reds and Diamondbacks have gone UNDER the total runs line.
• There has been at least one run scored in the first inning in each of the Reds’ last five games against NL West opponents.
• There has been at least one run scored in the first inning in each of the Diamondbacks’ last four home games.

Arizona Diamondbacks Player Prop Facts

• Corbin Carroll has hit a home run in three of the Diamondbacks’ last four games against opponents that held a losing record.
• Eduardo Rodriguez has recorded a win in four of his last five appearances.
• Gabriel Moreno has recorded at least one hit in each of the Diamondbacks’ last 13 games.
• Gabriel Moreno ranks 7th amongst qualified players for Batting Average (.307) this season.

Cincinnati Reds Player Prop Facts

• Eugenio Suarez has hit a home run in three of his last four appearances with his team as a road underdog against NL West opponents.
• Nick Lodolo has recorded five or more strikeouts in seven of his eight previous Friday appearances.
• Sal Stewart has recorded at least one hit in each of the Reds’ last 11 road games against NL opponents that held a winning record.

Matchup/League Facts

• The Diamondbacks rank 1st in the league for triples this season (33).
• The Diamondbacks rank 2nd in the league for strikeouts against this season (936).
• The Reds rank 30th in the league for hits this season (958).
• The Reds rank 30th in the league for batting average this season (.226).

Reds vs Diamondbacks Prediction

The Diamondbacks are 4-2 in their last 6 meetings against the Reds and are 3-1 in their last 4 meetings in Arizona.

In this Reds vs Diamondbacks Prediction, the Diamondbacks are coming as -145 home favorites. I like the Dbacks in this one with Eduardo Rodriguez on the mound, who has been the far better pitching option in this matchup than Nick Lodolo. The Dbacks are the best team against lefties this season and their bullpen has been much better lately and will be facing a struggling Reds team that is just 2-6 in its last 8 games. Take the Dbacks to win this one at home.

Nikos Lagouretos's Pick: Arizona Diamondbacks ML