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Chicago White Sox vs Washington Nationals Prediction 9/26/2025 Today’s MLB Picks
Pick details
Chicago (58-101) vs Washington (65-94)
September 26, 2025 at 06:45 PM EDT
The Line: Betting Odds: Washington — Over/Under:
The Chicago White Sox and Washington Nationals meet on Friday in MLB action from Nationals Park. Here’s a Chicago White Sox vs Washington Nationals prediction. We will look at this from a betting perspective and determine the best Nationals vs White Sox pick. We will examine:
The Chicago White Sox’ recent form and player performance
The Washington Nationals’ recent form and player performance
Recent betting trends and streaks involving the White Sox
Recent betting trends and streaks involving the Nationals
Recent betting trends in games played between the Nationals and White Sox
A summary that ties it all together and produces a favorable betting outcome for the Nationals and White Sox game.
Much like most of the season, the White Sox lost another game on Thursday. The White Sox scored three runs, while the pitching gave up five runs. Michael Taylor did have a strong game hitting a home run and driving in two RBIs. Davis Martin got the start and he went 4.1 innings giving up six hits and three runs.
The White Sox are averaging 3.93 runs while their pitching is giving up 4.57 runs per game. The offense is ranked 28th in the league while the defense is ranked 21st. Lenyn Sosa has hit 21 home runs and driven in 72 RBIs. Yoendrys Gómez comes into this game with a 3-3 record and a 4.92 ERA. The White Sox have lost his last three starts. In his last start against the San Diego Padres he went 5.1 innings giving up six hits and three runs.
The Nationals have not found a whole lot of success this season, but they hope they can finish the season strong with a few wins against the White Sox. On Wednesday, the Nationals scored four runs, and that was enough to pick up the win. James Wood had a huge game hitting two home runs and driving in two RBIs. Andrew Alvarez got the start and he went 4.1 innings giving up two hits and zero runs.
The Nationals are averaging 4.23 runs while their pitching is giving up 5.51 runs per game. The offense is ranked 20th but the pitching is ranked 29th. To find success in this series, the pitching is going to have to be a whole lot better. Getting the start for the Nationals will be Cade Cavalli and he sits with a 3-1 record and an ERA of 4.23. In his last start against the New York Mets he went five innings giving up five hits and zero runs.
The Nationals are going to start off this series strong, and it’s going to be because of the pitching here. Cavalii is on the mound and he’s someone I really trust is going to find success here. In his last start he gave up zero runs, and now he faces a much worse offense in the White Sox. Gomez has been fine, but not elite, and he’s going to give up three or four runs here. The bullpen will give a couple more, and Washington will come out ahead. Back the Nationals on the money line.
The Chicago White Sox’ recent form and player performance
The Washington Nationals’ recent form and player performance
Recent betting trends and streaks involving the White Sox
Recent betting trends and streaks involving the Nationals
Recent betting trends in games played between the Nationals and White Sox
A summary that ties it all together and produces a favorable betting outcome for the Nationals and White Sox game.
Another Loss for the White Sox
Much like most of the season, the White Sox lost another game on Thursday. The White Sox scored three runs, while the pitching gave up five runs. Michael Taylor did have a strong game hitting a home run and driving in two RBIs. Davis Martin got the start and he went 4.1 innings giving up six hits and three runs.
The White Sox are averaging 3.93 runs while their pitching is giving up 4.57 runs per game. The offense is ranked 28th in the league while the defense is ranked 21st. Lenyn Sosa has hit 21 home runs and driven in 72 RBIs. Yoendrys Gómez comes into this game with a 3-3 record and a 4.92 ERA. The White Sox have lost his last three starts. In his last start against the San Diego Padres he went 5.1 innings giving up six hits and three runs.
Chicago White Sox Player Prop Facts
- Michael A. Taylor has recorded a Double in four of his last five road appearances against NL opponents.
- Mike Tauchman has recorded at least one hit in each of his last nine road appearances against NL opponents that held a losing record.
- Luis Robert has hit a home run in two of the White Sox’s last three road games against the Nationals.
Nationals Look for Second Straight Win
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The Nationals have not found a whole lot of success this season, but they hope they can finish the season strong with a few wins against the White Sox. On Wednesday, the Nationals scored four runs, and that was enough to pick up the win. James Wood had a huge game hitting two home runs and driving in two RBIs. Andrew Alvarez got the start and he went 4.1 innings giving up two hits and zero runs.
The Nationals are averaging 4.23 runs while their pitching is giving up 5.51 runs per game. The offense is ranked 20th but the pitching is ranked 29th. To find success in this series, the pitching is going to have to be a whole lot better. Getting the start for the Nationals will be Cade Cavalli and he sits with a 3-1 record and an ERA of 4.23. In his last start against the New York Mets he went five innings giving up five hits and zero runs.
Washington Nationals Player Prop Facts
- Paul DeJong has hit a home run in three of his last seven appearances in night games against AL teams that held a losing record.
- CJ Abrams has recorded at least one Double in four of his five previous appearances at Nationals Park against AL Central opponents that held a losing record.
- Paul DeJong has recorded at least one hit in each of his last eight Friday night appearances against teams that held a losing record.
Chicago White Sox vs Washington Nationals Prediction
The Nationals are going to start off this series strong, and it’s going to be because of the pitching here. Cavalii is on the mound and he’s someone I really trust is going to find success here. In his last start he gave up zero runs, and now he faces a much worse offense in the White Sox. Gomez has been fine, but not elite, and he’s going to give up three or four runs here. The bullpen will give a couple more, and Washington will come out ahead. Back the Nationals on the money line.
