Chicago White Sox vs Cleveland Guardians Prediction 9/12/2025 Today’s MLB Picks

The Chicago White Sox and the Cleveland Guardians meet Friday in MLB action from Progressive Field. We will look at this from a betting perspective and determine the best bets for this game. Here’s a Chicago White Sox vs. Cleveland Guardians prediction.

Starting Pitching Matchup

The Chicago White Sox will send out Martin Perez for the start here and Perez is 1-4 with a 3.15 ERA and 39 strikeouts this season. In his last five starts against the Guardians, Perez is 0-2 with a 6.75 ERA and 13 strikeouts. Tanner Bibee will get the start for the Guardians here and Bibee is 9-11 with a 4.69 ERA and 139 strikeouts this season. In his career, Bibee is 3-0 with a 5.73 ERA and 20 strikeouts against the White Sox.

Chicago White Sox Recap

The Chicago White Sox come into this game looking to add on to their 5-1 win over the Guardians on Thursday to sit at 57-90 this season. After this series, the White Sox will head home for a series against the Baltimore Orioles.

White Sox Win 8 Of Last 10

Lenyn Sosa has 121 hits including 17 doubles, 20 home runs and 65 RBIs. Andrew Benintendi has 98 hits including 16 doubles, 18 home runs, 58 RBIs and a .247 batting average while Miguel Vargas has 104 hits, 30 doubles, 14 home runs and 52 RBIs. Brooks Baldwin has also added 31 RBIs while Luis Robert Jr. has a team-high 33 stolen bases along with 53 RBIs so far this season. Chase Meidroth has added 101 hits with 13 stolen bases as well as 15 doubles this season.

Cleveland Guardians Recap

The Cleveland Guardians come into this game looking to add on to their 3-2 win over the Kansas City Royals last time out to sit at 75-71 on the year. After this series, the Guardians will head on the road for an important division series against the Detroit Tigers.

Guardians Win 6 Of Last 7

Steven Kwan has 152 hits as part of a .275 batting average and 10 home runs, 25 doubles and 48 RBIs. Kyle Manzardo has 97 hits with 15 doubles, 2 triples, 25 home runs and 65 RBIs as well this year. Gabriel Arias has 20 doubles but also 139 strikeouts and Manzardo has 119 strikeouts so far this season. Arias has also added 10 home runs and 48 RBIs and Jose Ramirez has chipped in 28 home runs and 76 RBIs with 37 stolen bases as well. Carlos Santana has also added 89 hits with 11 home runs and 52 RBIs as well this season.

The Chicago White Sox @ Cleveland Guardians Betting Trends: September 12, 2025

• Probable Starting Pitcher: Tanner Bibee       Record this season: 9-11      ERA: 4.69
• Home Record: 3-5
• Last 5 against White Sox: 3-0

Why the Cleveland Guardians will win

• The White Sox have lost eight of their last nine night games at Progressive Field following a win.
• The Guardians have won seven of their last eight night games against AL Central opponents.
• The White Sox have failed to cover the run line in each of their last eight Friday games at Progressive Field.
• The Guardians have covered the run line in eight of their last nine night games against American League opponents following a win.
• The Guardians have won the first inning in seven of their last eight night games against AL Central opponents.
• The White Sox have trailed after 3 innings in three of their last four games at Progressive Field.
• The Guardians have led after 5 innings in seven of their last eight night games against AL Central opponents.

• Probable Starting Pitcher: Martin Perez      Record this season: 1-4      ERA: 3.15
• Road Record: 0-3
• Last 5 against Guardians: 1-0

Why the Chicago White Sox will win

• The White Sox have won nine of their last 10 games as underdogs after playing the previous day.
• The Guardians have lost three of their last four games as favorites following a home win.
• The White Sox have covered the run line in each of their last eight games following a home win.
• The Guardians have failed to cover the run line in each of their last six night games against the White Sox at Progressive Field following a home win.
• The Guardians have trailed after 5 innings in four of their last five games against opponents that held a losing record.
• The White Sox have won the first inning in four of their last five games at Progressive Field against opponents that held a winning record.

Total Runs Facts

• Five of the Guardians’ last six games have gone UNDER the total runs line.
• Four of the White Sox’s last five night games as underdogs have gone OVER the total runs line.
• The ‘Inning 1 OVER 0.5 runs’ market has hit in each of the Guardians’ last nine night games against AL Central opponents.
• The ‘Inning 1 OVER 0.5 runs’ market has hit in each of the White Sox’s last six games.

Cleveland Guardians Player Prop Facts

• Jose Ramirez has hit a home run in each of the Guardians’ last two home games against AL Central opponents that held a losing record.
• Brayan Rocchio has recorded at least one hit in each of the Guardians’ last eight games against AL Central opponents that held a losing record.
• Will Brennan has recorded at least one Double in each of his last three appearances with the Guardians as favorites against AL opponents.
• Jose Ramirez ranks T3rd in the league in Steals (37) this season.

Chicago White Sox Player Prop Facts

• Andrew Benintendi has hit a home run in each of his last two appearances in night games against AL Central teams that held a winning record.
• Martin Perez has recorded four or more strikeouts in six of his last seven appearances against AL Central opponents.
• Luis Robert has recorded at least one hit in 15 of his last 16 road appearances.

Matchup/League Facts

• The Guardians rank 30th in the league for hits this season (1077).
• The Guardians rank 30th in the league for batting average this season (.225).
• The White Sox rank 29th in the league for walks allowed this season (544).
• The White Sox rank 28th in the league for slugging percentage this season (.378).

Chicago White Sox vs. Cleveland Guardians Prediction

I’m on the White Sox in this one. I just feel it’s where the value lies in fading a Guardians team that I feel is overpriced considering they’ve had big time issues hitting against left-handed pitching this season. The White Sox are playing well in their own right at the moment, and I think they can steal the opener here. Give me Chicago in this one.