Chicago White Sox vs Arizona Diamondbacks Prediction 4/23/2026 Today’s MLB Picks

In this article, we will formulate a White Sox vs Diamondbacks Prediction for this MLB matchup on Thursday, April 23rd in the third game of this series. Let’s take a look at the prediction for this MLB matchup.

Arizona Diamondbacks Preview

The Arizona Diamondbacks have a 14-10 record this season and are sitting in the third place of the NL West. They have a 8-4 home record and are coming off an 11-7 home win against the White Sox. Their previous three games were a 5-11 home loss against the White Sox, and a 4-10 home loss and a 6-2 home win against the Blue Jays.

The Diamondbacks have a .251 batting average this season, .308 OBP and .422 Slugging percentage. Arizona’s pitching staff has a 4.43 ERA and 1.32 WHIP. Corbin Carroll is the team’s best hitter with a .312 batting average, also leading the team in RBI with 17. Ildemaro Vargas adds a team‑high 5 home runs.

Michael Soroka (R) is the projected starting pitcher for the Diamondbacks, and he has a 4-0 record, 2.78 ERA and 1.06 WHIP.

Chicago White Sox Preview

The Chicago White Sox have a 9-15 record this season and are sitting in the fourth place of the AL Central. They have a 6-9 away record and are coming off a 7-11 road loss against the Diamondbacks. Their previous three games were an 11-5 road win against the Diamondbacks, and a 7-4 road win and a 6-7 road loss against the Athletics.

The White Sox have a .222 batting average this season, .315 OBP and .387 Slugging percentage. Chicago’s pitching staff has a 5.13 ERA and 1.50 WHIP. Munetaka Murakami is the team’s best hitter with a .256 batting average, also leading the team in RBI with 19 and adding a team‑high 10 home runs.

Davis Martin (R) is the projected starting pitcher for the White Sox, and he has a 3-1 record, 2.16 ERA and 1.00 WHIP.

The Chicago White Sox @ Arizona Diamondbacks Betting Trends: April 23, 2026

• Probable Starting Pitcher: Michael Soroka      Record this season: 4-0      ERA: 2.78
• Home Record: 3-0
• Last 5 against White Sox: 0-0

Why the Arizona Diamondbacks will win

• The White Sox have lost each of their last eight Thursday games against teams that held a winning record.
• The Diamondbacks have won six of their last seven games against AL Central opponents.
• The Diamondbacks have covered the run line in seven of their last eight games against AL Central opponents.
• The White Sox have failed to cover the run line in four of their last five games against National League opponents after playing the previous day.
• The Diamondbacks have led after 5 innings in six of their last seven games as favorites against American League opponents.

• Probable Starting Pitcher: Davis Martin      Record this season: 3-1      ERA: 2.16
• Road Record: 2-1
• Last 5 against Diamondbacks: 0-1

Why the Chicago White Sox will win

• The White Sox have won four of their last five games as road underdogs following a loss.
• The Diamondbacks have lost four of their last six games as home favorites against AL Central opponents following a win.
• The road team has covered the run line in eight of the White Sox’s last nine games.
• The Diamondbacks have failed to cover the run line in five of their last six games as home favorites against AL Central opponents following a win.
• The White Sox have led after 3 innings in each of their last four day games against opponents that held a winning record.
• The White Sox have won the first inning in each of their last four games against opponents that held a winning record.
• The White Sox have led after 5 innings in four of their last five games.

Total Runs Facts

• Each of the White Sox’s last six road games have gone OVER the total runs line.
• Each of the last four games between the White Sox and Diamondbacks at Chase Field have gone OVER the total runs line.
• The ‘Inning 1 OVER 0.5 runs’ market has hit in each of the last seven games between the White Sox and Diamondbacks.
• The ‘Inning 1 OVER 0.5 runs’ market has hit in each of the White Sox’s last six games as road underdogs against NL West opponents.

Arizona Diamondbacks Player Prop Facts

• Ildemaro Vargas has hit at least one home run in each of the Diamondbacks’ last three games as favorites against AL Central opponents.
• Michael Soroka has recorded six or more strikeouts in four of his last five home appearances against AL opponents.
• Ildemaro Vargas has recorded at least one hit in each of his last 20 appearances.
• Michael Soroka has recorded a win in each of his last four appearances.
• Michael Soroka ranks T3rd in the league for Wins (4) this season.

Chicago White Sox Player Prop Facts

• Miguel Vargas has hit a home run in four of the White Sox’s last five games against opponents that held a winning record.
• Andrew Benintendi has recorded at least one hit in seven of his eight previous road appearances against the Diamondbacks.
• Munetaka Murakami ranks 2nd in the league in Home Runs (10) this season.

Matchup/League Facts

• The Diamondbacks rank 1st in the league for triples this season (9).
• The Diamondbacks rank 29th in the league for walks this season (64).
• The White Sox rank 30th in the league for doubles this season (28).
• The White Sox rank 28th in the league for hits this season (176).

White Sox vs Diamondbacks Prediction

The Diamondbacks are 4-2 in their last 6 meetings against the White Sox but both teams are tied 2-2 in their last 4 meetings in Arizona. Over is 6-1 in their last 7 meetings.

In this White Sox vs Diamondbacks Prediction, the Diamondbacks are coming as -150 home favorites. Arizona bounced back yesterday in another high-scoring affair, as there are 16 and 18 total runs scored in the two games of the series. Both pitchers have much worse expected ERA and the White Sox are 28th in bullpen ERA. Both teams are 13-1 to the over in their last 14 games combined, so take the over 9 once again in this one.

Nikos Lagouretos's Pick: Over 9