Chicago Cubs vs St. Louis Cardinals Prediction 7/29/2026 Today’s MLB Picks

The Chicago Cubs and the St. Louis Cardinals meet Wednesday in MLB action from Busch Stadium. We will look at this from a betting perspective and determine the best bets for this game. Here’s a Chicago Cubs vs. St. Louis Cardinals prediction.

Starting Pitching Matchup

The Chicago Cubs will send out Matthew Boyd for the start here and Boyd is 6-1 with a 3.81 ERA and 55 strikeouts this season. Dustin May will start here for St. Louis and is 5-7 with a 4.59 ERA and 103 strikeouts this season.

Chicago Cubs Recap

The Chicago Cubs come into this game looking to add on to their 10-2 win over St. Louis last time out to sit at 61-46 this season. After this series, the Cubs will head home for a series against the New York Yankees.

Cubs Win 7 Of Last 10

Entering Tuesday, Ian Happ has 82 hits with 18 doubles and 18 home runs and 45 RBIs while Alex Bregman has 98 hits with 17 doubles, a triple, 11 home runs and 46 RBIs. Nico Hoerner’s added 106 hits with 23 doubles, 5 home runs and 48 RBIs and Moises Ballesteros has 36 hits with 6 home runs and 23 RBIs. Pete Crow-Armstrong’s also added 114 hits with 19 doubles, 6 triples, 23 home runs and 60 RBIs as well on the year. Carson Kelly has also contributed 64 hits with 10 doubles, 6 home runs and 36 RBIs. Michael Busch has 96 hits wtih 18 doubles, 13 home runs and 56 RBIs. Dansby Swanson also has 77 hits with 16 home runs and 61 RBIs.

St. Louis Cardinals Recap

The St. Louis Cardinals come into this game looking to shake off their loss at the hands of the Cubs from Tuesday to sit at 53-54 on the year. After this series, the Cardinals will take on the Toronto Blue Jays on the road.

Cards Lose 8 Of Last 10

Going into Tuesday, Jordan Walker has 114 hits, 23 doubles, 22 home runs and 77 RBIs while Alec Burleson has 116 hits with 26 doubles, 15 home runs and 71 RBIs. JJ Wetherholt has 100 hits with 15 home runs and 40 RBIs while Ivan Herrera has 95 hits with 15 doubles, 12 home runs and 44 RBIs. Nolan Gorman has 39 hits with 7 home runs and 26 RBIs this season. Masyn Winn’s added 85 hits with 12 doubles and 43 RBIs and Nathan Church has 59 hits with 8 home runs and 30 RBIs this season. 

The Chicago Cubs @ St. Louis Cardinals Betting Trends: July 29, 2026

• Probable Starting Pitcher: Dustin May      Record this season: 5-7      ERA: 4.59
• Home Record: 3-3
• Last 5 against Cubs: 1-0

Why the St. Louis Cardinals will win

• The underdogs have won six of the Cardinals’ last seven games.
• The Cubs have lost each of their last three games as road favorites against the Cardinals following a win.
• The Cardinals have covered the run line in eight of their last nine games as underdogs against National League opponents following a loss.
• The Cubs have failed to cover the run line in five of their last six night games against the Cardinals following a win.
• The Cubs have trailed after 5 innings in five of their last six night games against opponents that held a losing record.
• The Cubs have trailed after 3 innings in four of their last five games at Busch Stadium against opponents that held a losing record.

• Probable Starting Pitcher: Matthew Boyd      Record this season: 6-1      ERA: 3.81
• Road Record: 2-0
• Last 5 against Cardinals: 3-2

Why the Chicago Cubs will win

• The Cubs have won 10 of their last 11 games against NL Central opponents that held a losing record.
• The Cardinals have lost seven of their last eight games against NL Central opponents that held a winning record.
• The Cubs have covered the run line in each of their last eight road games following a win.
• The Cardinals have failed to cover the run line each of their last four home games against teams that held a winning record.
• The Cubs have won the first inning in five of their last six games against opponents that held a losing record.
• The Cardinals have trailed after 5 innings in each of their last four home games against opponents that held a winning record.
• The Cardinals have trailed after 3 innings in four of their last five games against NL Central opponents that held a winning record.

Total Runs Facts

• Seven of the Cubs’ last eight games after playing the previous day have gone OVER the total runs line.
• Four of the last five games between the Cubs and Cardinals have gone OVER the total runs line.
• There has been at least one run scored in the first inning in eight of the Cubs’ last nine games as favorites.
• There has been at least one run scored in the first inning in each of the last four games between the Cubs and Cardinals.

St. Louis Cardinals Player Prop Facts

• Dustin May has recorded seven or more strikeouts in each of his last four appearances against NL Central opponents.
• JJ Wetherholt has recorded at least one hit in each of the Cardinals’ last eight games against the Cubs.
• Jimmy Crooks has hit a home run in two of his last three appearances with the Cardinals as underdogs against NL opponents.
• Alec Burleson ranks 9th in the league in Hits (116) this season.

Chicago Cubs Player Prop Facts

• Alex Bregman has hit a home run in each of the Cubs’ last two road games against opponents that held a losing record.
• Matthew Boyd has recorded a win in four of his last five appearances.
• Matthew Boyd has recorded five or more strikeouts in each of his last eight Wednesday appearances against teams that held a losing record.
• Pedro Ramirez has recorded at least one hit in each of his last eight appearances.
• Pete Crow-Armstrong ranks T4th in the league in Steals (26) this season.

Matchup/League Facts

• The Cardinals rank T2nd in the league for home runs allowed this season (106).
• The Cardinals rank T2nd in the league for home runs allowed this season (106).
• The Cubs rank 1st in the league for walks this season (463).
• The Cubs rank 1st in the league for walks this season (463).

Chicago Cubs vs. St. Louis Cardinals Prediction

I’m backing the Cubs in this one. I get the case to be made for St. Louis, but this is simply a case of two teams that are headed in different directions at this point. Chicago keeps finding ways to get it done while the Cardinals have fallen below .500 and it doesn’t look like it’s changing anytime soon. I look for Chicago to get it done once again so give me the Cubbies here.

Chris Ruffolo's Pick: Chicago Cubs -135