Jun 14, 2025; Chicago, Illinois, USA; Chicago Cubs pitcher Matthew Boyd (16) throws the ball against the Pittsburgh Pirates during the first inning at Wrigley Field. Mandatory Credit: David Banks-Imagn Images

Chicago Cubs vs St. Louis Cardinals Prediction 06/25/2025 Picks

Pick details

Chicago (46-33) vs St. Louis (44-36)

June 25, 2025 at 07:45 PM EDT

The Line: Betting Odds: St. Louis +1.5 — Over/Under: +8.5

(Get latest betting odds)

In this article, we will formulate a Cubs vs Cardinals prediction for this MLB game on Wednesday, June 25, at Busch Stadium in St. Louis, Missouri. Let’s take a look at the prediction for this MLB matchup.

Chicago Cubs Betting Preview

The Chicago Cubs (46-33, 21-18 Away) lost five of the last six games, their worst stretch of results this year. The Cubs lost the latest series to the Seattle Mariners and will not win the current one against the Cardinals after losing the opening two games, so they can only hope for a split. In Tuesday’s 8-7 defeat, Seiya Suzuki led the offense with a three-run homer, while Jameson Taillon took the loss after allowing eight runs on eight hits with three strikeouts and two walks in 4.0 innings.

This season, the Cubs average 5.37 runs per game (2nd in the MLB) on a .254/.324/.442 triple-slash. When it comes to pitching, the Cubs’ staff has a 3.89 ERA (16th) and 1.26 WHIP (14th). Seiya Suzuki leads the Cubs with a .262 batting average, 21 home runs, and 67 RBI this season.

Matthew Boyd will take the mound for the Cubs on Wednesday. The 34-year-old left-hander has a 6-3 record in 15 starts this year with a 2.84 ERA and 1.14 WHIP in 85.2 innings.

St. Louis Cardinals Betting Preview

The St. Louis Cardinals (44-36, 26-15 Home) swept the Chicago White Sox and defeated the Cincinnati Reds before winning the first two games of the current series against the Chicago Cubs. The Cards won 8-2 in Game 1 and then snatched a narrow 8-7 victory on Tuesday. Masyn Winn led the offense with four RBI, while Michael McGreevy pitched for 4.2 innings in a no-decision, allowing five runs on seven hits with one strikeout and one walk. Steven Matz was credited with the win.

This year, the Cardinals average 4.73 runs per game (8th in the MLB) on a .255/.327/.396 triple-slash. When it comes to pitching, the Cardinals’ staff has a 3.90 ERA (17th) and 1.25 WHIP (13th). Willson Contreras leads the Cardinals with a .248 batting average, ten home runs, and 50 RBI this season.

The projected starting pitcher for the Cardinals is Erick Fedde, who is 3-6 in 15 starts this season, with a 3.54 ERA and 1.30 WHIP in 84.0 innings.

Total Runs Facts

Each of the Cubs’ last five road games against NL Central opponents have gone OVER the total runs line.
Each of the last five games between the Cubs and Cardinals at Busch Stadium have gone OVER the total runs line.
The ‘Inning 1 UNDER 0.5 runs’ market has hit in each of the Cardinals’ last six night games against NL Central opponents.
The ‘Inning 1 UNDER 0.5 runs’ market has hit in each of the Cubs’ last five night games against National League opponents.

Matchup/League Facts

The Cardinals rank T28th in the league for triples this season (4).
The Cardinals rank 28th in the league for strikeouts this season (579).
The Cubs rank T3rd in the league for hits this season (697).
The Cubs rank 3rd in the league for doubles this season (139).

Cubs vs Cardinals Prediction

The teams have traded victories in the past couple of years, each recording five in the previous ten H2H encounters. Even though both games of the current series went Over, and these teams are generally Over-friendly for the bettors, I am going with Under in this one. The main reason for this is the pitching matchup. Matthew Boyd didn’t allow more than two runs in his last five starts, during which he surrendered only six runs. Erick Fedde, on the other hand, hasn’t posted such strong numbers recently, but he hasn’t allowed more than three runs in his previous five starts. Go with Under.

Oliver Zivic's Pick: Under 8.5

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