Chicago Cubs vs Chicago White Sox Prediction 5/17/2026 Today’s MLB Picks

The Chicago Cubs and Chicago White Sox meet Sunday in MLB action at Wrigley Field. Here’s a Chicago Cubs vs. Chicago White Sox Prediction. This article will include a Chicago Cubs vs. Chicago White Sox Pick.

Chicago Cubs Betting Preview

The Chicago Cubs are 29-17 on the year and play the Brewers and Astros next. The Chicago Cubs are batting .247 on the season and have a .341 OBP, and a .406 slugging percentage. The Chicago Cubs’ pitching staff has a 3.90 ERA and a 1.19 WHIP. Nico Hoerner leads the Chicago Cubs with 48 hits and 29 RBI, while Alex Bregman and Pete Crow-Armstrong have combined for 86 hits and 34 RBI.

Colin Rea gets the ball for the Chicago Cubs, and he is 4-2 with a 4.68 ERA and 36 strikeouts this season. Rea is 0-0 with a 2.45 ERA and 5 strikeouts in his career against the Chicago White Sox.

Chicago White Sox Betting Preview

The Chicago White Sox are 23-22 on the year and play the Mariners and Giants next. The Chicago White Sox are batting .234 on the season, have a .324 OBP, and have a .401 slugging percentage. The Chicago White Sox pitching staff has a 4.32 ERA and a 1.37 WHIP. Chase Meidroth leads the Chicago White Sox with 43 hits and 10 RBI, while Colson Montgomery and Miguel Vargas have combined for 77 hits and 58 RBI.

Erick Fedde gets the ball for the Chicago White Sox, and he is 0-4 with a 3.77 ERA and 26 strikeouts this season. Fedde is 0-3 with an 8.53 ERA and 28 strikeouts in his career against the Chicago Cubs.

Why the Chicago White Sox will win

• The White Sox have won seven of their last eight games as underdogs following a home win.
• The Cubs have lost three of their last four games as road favorites.
• The White Sox have covered the run line in 11 of their last 12 games as underdogs after playing the previous day.
• The Cubs have failed to cover the run line in each of their last six day games following a road loss.
• The Cubs have trailed after 5 innings in three of their last four games against American League opponents.

Why the Chicago Cubs will win

• The White Sox have lost each of their last seven day games against NL Central opponents that held a winning record.
• The Cubs have won each of their last nine games as road favorites against American League opponents following a road loss.
• The Cubs have covered the run line in each of their last six games at Rate Field following a road loss.
• The White Sox have failed to cover the run line in eight of their last nine home games against National League opponents following a home win.
• The White Sox have trailed after 3 innings in eight of their last 10 day games against NL Central opponents.
• The Cubs have led after 5 innings in each of their last three day games against opponents that held a winning record.

Total Runs Facts

• Each of the White Sox’s last five home games has gone OVER the total runs line.
• Each of the Cubs’ last three games as favorites against the White Sox has gone OVER the total runs line.
• The ‘Inning 1 OVER 0.5 runs’ market has hit in each of the White Sox’s last six games against NL Central opponents.
• The ‘Inning 1 UNDER 0.5 runs’ market has hit in seven of the Cubs’ last eight day games against American League opponents.

Chicago White Sox Player Prop Facts

• Miguel Vargas has hit a home run in each of the White Sox’s last three games at Rate Field against opponents that held a winning record.
• Miguel Vargas has recorded at least one hit in each of the White Sox’s last 11 home games.
• Colson Montgomery ranks T8th in the league in Home Runs (13) this season.

Chicago Cubs Player Prop Facts

• Carson Kelly has recorded at least one hit in each of his last nine appearances against AL Central opponents.
• Michael Conforto has hit a home run in three of his last seven appearances against the White Sox after playing the previous day.

Matchup/League Facts

• The White Sox rank T26th in the league for hits this season (345).
• The White Sox rank 6th in the league for slugging percentage this season (.409).
• The Cubs rank 29th in the league for home runs allowed this season (62).
• The Cubs rank 4th in the league for runs scored this season (233).

Chicago Cubs vs Chicago White Sox Prediction

The Cubs have cooled off over the last week and Rea hasn’t been great through 42.1 innings with a 4.68 ERA and 1.42 WHIP. Fedde has been sharper through 43 innings with a 3.77 ERA and 1.16 WHIP. Fedde needs to do a better job of keeping the ball in the park but outside of that, he’s been sharp. The White Sox, overall, are winning for once and have a chance to keep making a statement to the rest of the league. They’ve had fun this series and should be able to finish it off strong. I’m going to keep backing the White Sox.

Randy Chambers's Pick: Chicago White Sox