Chicago Cubs vs Arizona Diamondbacks Prediction 8/25/2026 Today’s MLB Picks

In this article, we will formulate a Cubs vs Diamondbacks Prediction for this MLB matchup on Tuesday, August 25th in the second game of this series. Let’s take a look at the prediction for this MLB matchup.

Arizona Diamondbacks Preview

The Arizona Diamondbacks have a 69-63 record this season and sit in 3rd place in the NL West. They have a 38-29 home record and are coming off a 0-7 home loss against the Cubs. They will face the Giants and the Phillies next.

The Arizona Diamondbacks have a .245 batting average this season, .318 OBP, and .401 Slugging percentage. Arizona’s pitching staff has a 4.19 ERA and 1.29 WHIP. Gabriel Moreno is the Diamondbacks’ best hitter with a .303 batting average. Ketel Marte leads the team in RBI with 67, while Nolan Arenado adds a team-high 21 home runs.

Brandon Pfaadt (R) is the projected starting pitcher for the Diamondbacks, holding a 7-1 record, 3.39 ERA, and 1.14 WHIP.

Chicago Cubs Preview

The Chicago Cubs have a 76-56 record this season and sit in 2nd place in the NL Central. They have a 38-29 road record and are coming off a 7-0 road win against the Diamondbacks. They will face the Reds and the Brewers next.

The Chicago Cubs have a .250 batting average this season, .339 OBP, and .423 Slugging percentage. Chicago’s pitching staff has a 4.12 ERA and 1.26 WHIP. Pete Crow-Armstrong is the Cubs’ best hitter with a .278 batting average, while leading the team in RBI with 83, also adding a team-high 33 home runs.

Clay Holmes (R) is the projected starting pitcher for the Cubs, holding a 5-6 record, 2.49 ERA, and 1.11 WHIP.

The Chicago Cubs @ Arizona Diamondbacks Betting Trends: August 25, 2026

• Probable Starting Pitcher: Brandon Pfaadt      Record this season: 7-1      ERA: 3.39
• Home Record: 3-0
• Last 5 against Cubs: 1-2

Why the Arizona Diamondbacks will win

• The Diamondbacks have won each of their last six games as underdogs following a home loss.
• The Cubs have lost six of their last nine games as road favorites against NL West opponents following a road win.
• The Diamondbacks have covered the run line in each of their last seven games as underdogs against National League opponents following a loss.
• The Cubs have failed to cover the run line in eight of their last 10 games as road favorites against NL West opponents following a win.
• The Cubs have trailed after 3 innings in four of their last five road night games.

• Probable Starting Pitcher: Clay Holmes      Record this season: 5-6      ERA: 2.49
• Road Record: 3-3
• Last 5 against Diamondbacks: 1-1

Why the Chicago Cubs will win

• The Cubs have won each of their last 11 games against NL West opponents that held a winning record.
• The Diamondbacks have lost each of their last four night games after playing the previous day.
• The Cubs have covered the run line in each of their last nine night games against National League opponents.
• The Diamondbacks have failed to cover the run line in four of their last five games as underdogs.
• The Cubs have led after 3 innings in each of their last eight games against the Diamondbacks.
• The Cubs have led after 5 innings in eight of their last nine games against the Diamondbacks.
• The Cubs have won the first inning in three of their last four night games.

Total Runs Facts

• Seven of the Diamondbacks’ last eight games as home underdogs have gone UNDER the total runs line.
• Each of the Cubs’ last four road games against NL West opponents have gone UNDER the total runs line.
• There has been no run scored during the first inning in seven of the last eight night games between the Cubs and Diamondbacks.
• There has been no run scored during the first inning in each of the Cubs’ last four games at Chase Field.

Arizona Diamondbacks Player Prop Facts

• Ildemaro Vargas has hit a home run in two of the Diamondbacks’ last three games as underdogs against NL opponents.
• Brandon Pfaadt has recorded a win in seven of his last nine appearances against NL opponents.
• Brandon Pfaadt has recorded five or more strikeouts in four of his last five appearances against the Cubs.
• Tim Tawa has recorded at least one hit in each of the Diamondbacks’ last nine night games against opponents that held a winning record.
• Gabriel Moreno ranks 7th amongst qualified players for Batting Average (.303) this season.

Chicago Cubs Player Prop Facts

• Pete Crow-Armstrong has hit at least one home run in seven of the Cubs’ last nine games as favorites against NL West opponents.
• Clay Holmes has recorded a win in six of his last seven appearances with his team as a road favorite against NL opponents .
• Clay Holmes has recorded four or more strikeouts in each of his last four road appearances against NL opponents.
• Seiya Suzuki has recorded at least one hit in each of the Cubs’ last nine games against NL West opponents.
• Pete Crow-Armstrong ranks 2nd amongst qualified players for Slugging Percentage (.554) this season.

Matchup/League Facts

• The Diamondbacks rank 1st in the league for triples this season (35).
• The Diamondbacks rank 2nd in the league for strikeouts against this season (957).
• The Cubs rank 1st in the league for on-base percentage this season (.339).
• The Cubs rank 1st in the league for walks this season (562).

Cubs vs Diamondbacks Prediction

The Cubs are 6-1 in their last 7 meetings against the Diamondbacks and have won two of their last three visits in Arizona.

In this Cubs vs Diamondbacks Prediction, both teams are coming at a pickem price. I like the Cubs in this one, as both starting pitchers have been fairly equal, but Holmes has been better on the road with a 2.91 ERA, while Pfaadt has been weaker at home with a 3.56 ERA. The Cubs have better numbers all across the board lately, with a better overall batting average, better batting average vs righties and a better bullpen ERA, so I expect them to get the job on the road in this one.

Nikos Lagouretos's Pick: Chicago Cubs ML