Your cart is currently empty!

Cardinals vs White Sox Prediction 06/19/2025 Picks
Pick details
St. Louis (38-35) vs Chicago (23-50)
June 19, 2025 at 02:10 PM EDT
The Line: Betting Odds: Chicago — Over/Under:
In this article we will formulate a Cardinals vs White Sox prediction for this MLB game on Thursday, June 19th at Rate Field in Chicago, Illinois. Let’s take a look at the prediction for this MLB doubleheader.
Chicago White Sox Betting Preview
The Chicago White Sox are 23-50 this year after they lost game one by a score of 12-2 on Tuesday night. Chicago led 1-0 in the first inning, but they allowed 12 of the next 13 runs in the blowout loss. The White Sox recorded six hits and they committed two errors in the game, while they were led by Capra and Quero, who both had one RBI in the loss. Chicago started Smith, who allowed six hits and five earned runs over 4.1 innings for the loss, while four relievers all allowed at least one earned run.
Prior to this series, the White Sox lost all three games against the Rangers and two out of three against the Astros. Chicago has lost six games in a row and they are currently last in the AL Central standings. The Chicago pitching staff has a 4.23 ERA with a 1.41 WHIP and a .255 opponent batting average, while the offense has scored 250 runs with a .222 batting average and a .293 on base percentage this season. Miguel Vargas has led Chicago with 10 home runs and 31 RBIs, while Luis Robert has added six home runs and 28 RBIs this year. The projected starting pitcher for Chicago in game one is Sean Burke, who is 3-7 with a 4.71 ERA and a 1.44 WHIP over 70.2 innings pitched this year. The projected starting pitcher for game two is Mike Vasil, who is 3-2 with a 1.99 ERA and a 1.28 WHIP over 45.1 innings pitched this season.
St. Louis Cardinals Betting Preview
The St. Louis Cardinals are 38-35 this season after they won game one in blowout fashion on Tuesday night. St. Louis had their lead cut to 6-2 in the fifth inning, but they scored the last six runs in the game for the easy win. The Cardinals recorded 13 hits in the game and they were led by Herrera, who went 2-5 with four RBIs in the win. St. Louis started Liberatore, who allowed five hits and two earned runs over 6.0 innings for the win, while O’Brien and Granillo pitched three scoreless innings in relief.
Prior to this series, the Cardinals lost three out of four against the Brewers and all three games against the Blue Jays. St. Louis has lost seven of their last nine games and they are currently third in the NL Central standings. The St. Louis pitching staff has a 3.97 ERA with a 1.27 WHIP and a .254 opponent batting average, while their offense has scored 340 runs with a .257 batting average and a .328 on base percentage this season. Wilson Contreras has led St. Louis with nine home runs, 45 RBIs, and three stolen bases, while Nolan Arenado has added eight home runs and 36 RBIs this year. The projected starting pitcher for St. Louis in game one is Erick Fedde, who is 3-6 with a 3.65 ERA and a 1.28 WHIP over 79.0 innings pitched this season. The projected starting pitcher for game two is Michael McGreevy, who is 1-1 with a 3.09 ERA and a 0.86 WHIP over 11.2 innings pitched this year.
Why the White Sox will beat the Cardinals
The White Sox have won each of their last seven games at Rate Field following a home loss.
The Cardinals have lost each of their last four day games following a road win.
The White Sox have covered the run line in each of their last seven home games following a home loss.
The Cardinals have failed to cover the run line in each of their last four day games against American League opponents following a win.
The White Sox have won the first inning in four of their last five day games against NL Central opponents that held a winning record.
Why the Cardinals will beat the White Sox
The White Sox have lost 16 of their last 17 games against NL Central opponents following a loss.
The Cardinals have won four of their last five games at Rate Field.
The road team has covered the run line in seven of the last eight games between the Cardinals and White Sox.
The White Sox have failed to cover the run line in each of their last five games against NL Central opponents.
The Cardinals have led after 3 innings in four of their last five games against the White Sox at Rate Field.
The White Sox have trailed after 5 innings in five of their last six games.
Total Runs Facts
Seven of the Cardinals’ last eight games against American League opponents have gone OVER the total runs line.
Five of the White Sox’s last six home games on the first leg of a doubleheader have gone UNDER the total runs line.
The ‘Inning 1 OVER 0.5 runs’ market has hit in nine of the Cardinals’ last 10 games against American League opponents.
The ‘Inning 1 OVER 0.5 runs’ market has hit in seven of the White Sox’s last eight games against National League opponents.
Chicago White Sox Player Prop Facts
Miguel Vargas has hit at least one home run in seven of his last 10 appearances against NL Central opponents that held a winning record.
Miguel Vargas has scored a run in each of the White Sox’s last four day games.
Adrian Houser has recorded five strikeouts in three of his last four appearances against NL Central opponents that held a winning record.
Miguel Vargas has recorded at least one RBI in six of his last seven appearances in day games against NL Central teams that held a winning record.
Andrew Benintendi has recorded at least one hit in each of his last seven appearances against NL Central opponents that held a winning record.
Adrian Houser has recorded a win in each of his three previous appearances at Rate Field against opponents that held a winning record.
Miguel Vargas has recorded a Double in each of the White Sox’s last four games against NL opponents that held a winning record.
St. Louis Cardinals Player Prop Facts
Willson Contreras has recorded a Double in three of the Cardinals’ last four games against AL Central opponents.
Alec Burleson has hit a home run in three of his last five road appearances after not playing the previous day.
Brendan Donovan has scored at least one run in each of his last five appearances after not playing the previous day.
Erick Fedde has recorded four or more strikeouts in each of his last five appearances at Rate Field.
Willson Contreras has recorded an RBI in seven of the Cardinals’ last eight day games.
Nolan Arenado has recorded at least one hit in each of the Cardinals’ last seven games.
White Sox vs Cardinals Prediction
St. Louis was able to pick up an easy win to start this series on Tuesday night, but they have struggled over the last few series. The Cardinals are 16-21 on the road this year, while the White Sox are 16-19 at home. Chicago has lost six games in a row and they have scored two runs or fewer in three of their last four. In game one, I think Fedde has the edge on the mound, so I like the Cardinals -1.5. In game two, I think we will see a lower scoring game and I like the under.