Sep 14, 2025; Toronto, Ontario, CAN; Toronto Blue Jays first base Vladimir Guerrero Jr. (27) runs back to the dugout after the second inning against the Baltimore Orioles at Rogers Centre. Mandatory Credit: Kevin Sousa-Imagn Images

Blue Jays vs Rays Prediction 9/15/2025 Today’s MLB Picks

Pick details

Toronto (87-62) vs Tampa Bay (73-76)

September 15, 2025 at 07:35 PM EDT

The Line: Betting Odds: Tampa Bay +110 — Over/Under: 8.5

(Get latest betting odds)

In this article we will formulate a Blue Jays vs Rays prediction for this MLB game on Monday, September 15th at George M. Steinbrenner Field in Tampa, Florida. Let’s take a look at the prediction for this MLB matchup.

Toronto Blue Jays Betting Preview

The Toronto Blue Jays are 87-62 this season after they won all three games against Baltimore by scores of 6-1, 5-4, and 11-2. In their game three win, Toronto trailed 1-0 in the first inning, but scored 11 of the last 12 runs for the blowout victory. The Blue Jays recorded 14 hits in the game and they were led by Clement and Barger, who both had three RBIs in the win. Toronto started Bieber, who allowed four hits and one earned run over 6.0 innings for the win, while Varland allowed one earned run in relief. 

Prior to that series, the Blue Jays won two out of three against the Astros, but did lose two out of three against the Yankees before that. Toronto has won four games in a row and they continue to lead the AL East standings. The Toronto pitching staff has a 4.16 ERA with a 1.26 WHIP and a .239 opponent batting average, while their offense has scored 749 runs with a .270 batting average and a .338 on base percentage this season. Vladimir Guerrero Jr. has led Toronto with 23 home runs and 80 RBIs, while George Springer has added 29 home runs and 75 RBIs this year. The projected starting pitcher for Toronto is Trey Yesavage, who is making his MLB debut. 

Tampa Bay Rays Betting Preview

The Tampa Bay Rays are 73-76 this year after they lost two out of three against the Cubs by scores of 4-6, 5-4, and 3-4. In their game three loss, Tampa Bay led 2-0 in the first and 3-1 in the third, but didn’t score over the last six innings in the defeat. The Rays recorded nine hits in the game and they were led by Lowe, Diaz, and Caminero, who all had one RBI in the loss. TB started Houser, who allowed seven hits and two earned runs over 6.0 innings, while Uceta allowed two earned runs and picked up the loss. 

Prior to that series, the Rays lost two out of three against the White Sox and three out of four against the Guardians. Tampa Bay has lost seven of their last nine games and they are currently fourth in the AL East standings. The Tampa Bay pitching staff has a 3.90 ERA with a 1.22 WHIP and a .237 opponent batting average, while the offense has scored 667 runs with a .252 batting average and a .313 on base percentage this season. Junior Caminero has led Tampa Bay with 44 home runs and 108 RBIs, while Brandon Lowe has added 28 home runs and 75 RBIs for the Rays this year. The projected starting pitcher for Tampa Bay is TBD. 

Why the Blue Jays will beat the Rays 

The Rays have lost seven of their last eight games after playing the previous day.
The Blue Jays have won seven of their last eight night games against AL East opponents following a win.
The Rays have failed to cover the run line in each of their last six games against American League opponents.
The Blue Jays have covered the run line in five of their last six road games.

Total Runs Facts

Four of the Blue Jays’ last five road games against AL East opponents have gone UNDER the total runs line.
Each of the Rays’ last three games against AL East opponents have gone OVER the total runs line.
The ‘Inning 1 OVER 0.5 runs’ market has hit in seven of the Rays’ last eight night games against AL East opponents.
The ‘Inning 1 UNDER 0.5 runs’ market has hit in each of the Blue Jays’ last six Monday night games against AL East opponents.

Tampa Bay Rays Player Prop Facts

Brandon Lowe has hit a home run in three of the Rays’ last four home games against the Blue Jays.
Taylor Walls has recorded a Double in each of his last three appearances against AL East opponents that held a winning record.
Brandon Lowe has recorded at least one hit in each of the Rays’ last eight games against the Blue Jays.

Toronto Blue Jays Player Prop Facts

Jose Berrios has recorded a win in each of his last three appearances in night games against AL teams that held a losing record.
Jose Berrios has recorded five or more strikeouts in 14 of his last 18 appearances against AL East opponents that held a losing record.
Daulton Varsho has hit a home run in four of the Blue Jays’ last seven road games.
Ernie Clement has recorded a Double in each of his last three road appearances against AL East opponents.
Bo Bichette has recorded at least one hit in each of his last 12 appearances against AL opponents.

Blue Jays vs Rays Prediction 

Toronto comes into this matchup looking for their fifth straight win, as they continue to hold off the Yankees in the East. The Blue Jays are 37-37 on the road this year, while the Rays are 38-36 at home. Tampa Bay is trending in the wrong direction and while they haven’t announced a starting pitcher, it looks like it might be Joe Boyle. Toronto is going with Yesavage, who is making his MLB debut and has pitched well in the minors this year. I have no idea what to expect with this pitching matchup, but I will take the Jays at a decent price here.

David Racey's Pick: Blue Jays ML

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