Jun 20, 2025; Bronx, New York, USA;  Baltimore Orioles relief pitcher Félix Bautista (74) celebrates with catcher Gary Sánchez (99) after defeating the New York Yankees 5-3 at Yankee Stadium. Mandatory Credit: Wendell Cruz-Imagn Images

Baltimore Orioles vs New York Yankees Prediction 06/21/2025 Picks

Pick details

Baltimore (33-42) vs New York (43-32)

June 21, 2025 at 01:05 PM EDT

The Line: Betting Odds: New York -1.5 — Over/Under: +9.5

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The Baltimore Orioles and New York Yankees meet Saturday in MLB action at Yankee Stadium. Here’s a Baltimore Orioles vs New York Yankees Prediction. This article will include a Baltimore Orioles vs New York Yankees Pick.

Baltimore Orioles Betting Preview

The Baltimore Orioles are 33-42 on the year and play the Rangers, Rays, and Rangers next. The Baltimore Orioles are batting .241 on the season, have a .306 OBP, and a .397 slugging percentage. The Baltimore Orioles pitching staff has a 4.90 ERA and a 1.43 WHIP. Gunnar Henderson leads the Baltimore Orioles with 75 hits and 23 RBI, while Jackson Holliday and Ryan O’Hearn have combined for 134 hits and 56 RBI. 

Zach Eflin gets the ball for the Baltimore Orioles, and he is 6-3 with a 4.81 ERA and 38 strikeouts this season. Eflin is 3-3 with a 2.44 ERA and 54 strikeouts in his career against the New York Yankees.

New York Yankees Betting Preview

The New York Yankees are 43-32 on the year and play the Reds, Athletics, and Blue Jays next. The New York Yankees are batting .254 on the season, have a .336 OBP, and a .449 slugging percentage. The New York Yankees pitching staff has a 3.54 ERA and a 1.19 WHIP. Aaron Judge leads the New York Yankees with 104 hits and 61 RBI while Paul Goldschmidt and Cody Bellinger have combined for 148 hits and 70 RBI.

Clarke Schmidt gets the ball for the New York Yankees, and he is 3-3 with a 3.16 ERA and 60 strikeouts this season. Schmidt is 3-4 with a 4.03 ERA and 33 strikeouts in his career against the Baltimore Orioles.

Why the New York Yankees will win

The Yankees have won five of their last six day games at Yankee Stadium following a loss.
The Orioles have lost five of their last six day games against AL East opponents following a win.
The Yankees have covered the run line in five of their last six day games at Yankee Stadium following a home loss.
The Orioles have failed to cover the run line in five of their last six day games against AL East opponents.
The Yankees have led after 3 innings in three of their last four home games against AL East opponents.
The Yankees have led after 5 innings in six of their last seven day games against opponents that held a losing record.

Why the Baltimore Orioles will win

The Yankees have lost each of their last five games as favorites against AL East opponents.
The underdogs have won six of the Yankees’ last seven games.
The Orioles have covered the run line in each of their last 11 Saturday games as underdogs against American League opponents.
The Yankees have failed to cover the run line in seven of their last eight games as favorites.

New York Yankees Player Prop Facts

Aaron Judge has hit a home run in each of the Yankees’ last five games against the Orioles at Yankee Stadium.
Aaron Judge has scored at least one run in each of his last seven appearances against the Orioles at Yankee Stadium.
Aaron Judge has recorded at least one RBI in each of the Yankees’ last six games as favorites against the Orioles.
Bryan De La Cruz has recorded at least one hit in each of his last seven home appearances.
Aaron Judge ranks 1st amongst qualified players for Batting Average (.371) this season.

Baltimore Orioles Player Prop Facts

Colton Cowser has hit a home run in three of the Orioles’ last four road games against AL East opponents.
Zach Eflin has recorded five or more strikeouts in four of his five previous appearances at Yankee Stadium against opponents that held a winning record.
Gunnar Henderson has recorded at least one hit in each of the Orioles’ last 13 games.
Ramon Laureano has scored at least one run in each of his last five appearances with the Orioles as road underdogs against AL opponents.
Gunnar Henderson has recorded at least one RBI in four of the Orioles’ last five day games against opponents that held a winning record.
Gary Sanchez has recorded a Double in three of his last four appearances against the Yankees after playing the previous day.
Zach Eflin has recorded a win in three of his last four appearances with the Orioles as road underdogs.

Baltimore Orioles vs New York Yankees Prediction

The Yankees should be favored, as they’re the better team and Schmidt is the better pitcher. Schmidt has been money this month, allowing 13 hits and 3 runs in his last 19.1 innings. Eflin hasn’t been great, with an ERA of nearly 5, and he has a 5.18 ERA and .277 allowed batting average in 33 road innings. However, this is the best ball the Orioles have played all season, and it’s sustainable given the talent. The Orioles weren’t as bad as they showed in the first couple of months. The Yankees have one win in the last week. I’ll throw the pitching matchup out of the window and side with the O’s over the struggling Yankees.

Randy Chambers's Pick: Baltimore Orioles

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