Astros vs Guardians Prediction 4/21/2026 Today’s MLB Picks

In this article we will formulate an Astros vs Guardians prediction for this MLB game on Tuesday, April 21st at Progressive Field in Cleveland, Ohio. Let’s take a look at the prediction for this MLB matchup. 

Houston Astros Betting Preview

The Houston Astros are 9-15 this season after they won game one in this series by a score of 9-2 on Monday night. Houston blew a 2-0 lead early in the game, but they scored the last seven runs to pull away with the win. The Astros recorded 13 hits in the game and they were led by Correa, Walker, and Paredes, who all had two RBIs. Arrighetti allowed five hits and two earned runs over 5.0 innings for the win, while Murray threw two scoreless innings in relief. Prior to this series, Houston lost all three against the Cardinals, but did win two out of three against the Rockies before that. 

This season, Houston has a 5.93 ERA with a 1.62 WHIP and a .262 opponent batting average, while they have scored 130 runs with a .260 batting average and a .350 on base percentage. Yordan Alvarez has led the Astros with 10 home runs and 21 RBIs, while Christian Walker has added five home runs and 18 RBIs. The projected starting pitcher for Houston is Ryan Weiss, who is 0-2 with a 6.75 ERA and a 2.05 WHIP over 14.2 innings pitched this season. 

Cleveland Guardians Betting Preview

The Cleveland Guardians are 13-11 this year after they lost game one by a score of 9-2 last night. Cleveland scored once in the first inning and once in the third, but couldn’t find anymore offense in the loss. The Guardians recorded eight hits and they committed two errors, while they were led by Hoskins and Valera, who both had one RBI in the game. Cecconi allowed 10 hits and six earned runs over 5.0 innings for the loss, while Festa allowed one earned run in relief. Prior to this series, Cleveland won three out of four against the Orioles, but lost two out of three against the Cardinals before that. 

This season, Cleveland has a 4.09 ERA with a 1.27 WHIP and a .228 opponent batting average, while they have scored 97 runs with a .227 batting average and a .314 on base percentage. Brayan Rocchio has led the Guardians with three home runs and 14 RBIs, while Jose Ramirez has added six home runs and 12 RBIs. The projected starting pitcher for Cleveland is Parker Messick, who is 3-0 with a 1.05 ERA and a 0.78 WHIP over 25.2 inning pitched this year. 

Why the Cleveland Guardians will win

• The Guardians have won each of their last 10 Tuesday games against American League opponents that held a losing record.
• The Astros have lost seven of their last eight road games after playing the previous day.
• The Guardians have covered the run line in each of their last four night games against American League opponents following a loss.
• The Astros have failed to cover the run line in five of their last six games against American League opponents following a road win.
• The Astros have trailed after 3 innings in five of their last six night games against American League opponents that held a winning record.

Why the Houston Astros will win

• The underdogs have won each of the last four games between the Astros and Guardians.
• The Guardians have lost seven of their last eight games against AL West opponents that held a losing record.
• The road team has covered the run line in each of the Astros’ last five games.
• The Guardians have failed to cover the run line in each of their last five games as favorites against AL West opponents.
• The Guardians have trailed after 5 innings in each of their last four games against AL West opponents.

Total Runs Facts

• Twelve of the Astros’ last 13 games against American League opponents have gone OVER the total runs line.
• Five of the Guardians’ last six games as favorites against AL West opponents have gone OVER the total runs line.
• The ‘Inning 1 OVER 0.5 runs’ market has hit in each of the Astros’ last nine games as underdogs against American League opponents.
• The ‘Inning 1 OVER 0.5 runs’ market has hit in each of the Guardians’ last four home games against AL West opponents.

Cleveland Guardians Player Prop Facts

• Jose Ramirez has hit at least one home run in three of the Guardians’ last six games as favorites.
• Jose Ramirez has recorded at least one hit in each of his last 10 home appearances against the Astros after playing the previous day.

Houston Astros Player Prop Facts

• Yordan Alvarez has hit a home run in three of the Astros’ last four games against opponents that held a winning record.
• Yordan Alvarez has recorded at least one hit in each of his last nine appearances in night games against AL Central teams that held a winning record.

Astros vs Guardians Prediction 

Houston was able to get a much needed win to start this series on Monday, but they have allowed at least seven runs in three of their last four games. The Astros are 2-9 on the road this year, while the Guardians are 7-4 at home. Cleveland has won three of their last five games and they are starting Messick, who has been elite to start the season. The Astros are starting Weiss, who has allowed 10 earned runs and 15 hits over his last 8.2 innings. Take Cleveland to get the win here.

David Racey's Pick: Guardians ML