Arizona Diamondbacks vs St. Louis Cardinals Prediction 5/24/25 MLB Picks

The Arizona Diamondbacks and St. Louis Cardinals meet Saturday in MLB action at Busch Stadium. Here’s a Arizona Diamondbacks vs St. Louis Cardinals Prediction. This article will include a Arizona Diamondbacks vs St. Louis Cardinals Pick.

Arizona Diamondbacks Betting Preview

The Arizona Diamondbacks are 26-25 on the year and play the Pirates, Nationals, and Braves next. The Arizona Diamondbacks are batting .253 on the season, have a .333 OBP, and a .447 slugging percentage. The Arizona Diamondbacks pitching staff has a 4.64 ERA and a 1.32 WHIP. Corbin Carroll leads the Arizona Diamondbacks with 58 hits and 34 RBI, while Josh Naylor and Geraldo Perdomo have combined for 107 hits and 66 RBI. 

Merrill Kelly gets the ball for the Arizona Diamondbacks, and he is 5-2 with a 3.26 ERA and 52 strikeouts this season. Kelly is 3-1 with a 2.75 ERA and 30 strikeouts in his career against the St. Louis Cardinals.

St. Louis Cardinals Betting Preview

The St. Louis Cardinals are 28-23 on the year and play the Orioles, Rangers, and Royals next. The St. Louis Cardinals are batting .262 on the season, have a .334 OBP, and a .401 slugging percentage. The St. Louis Cardinals pitching staff has a 3.72 ERA and a 1.21 WHIP. Brendan Donovan leads the St. Louis Cardinals with 61 hits and 22 RBI while Lars Nootbaar and Willson Contreras have combined for 94 hits and 53 RBI.

Matthew Liberatore gets the ball for the St. Louis Cardinals, and he is 3-3 with a 2.92 ERA and 47 strikeouts this season. This will be Liberatore’s first career game against the Arizona Diamondbacks.

Why the St. Louis Cardinals will win

• The Cardinals have won 11 of their last 12 games against National League opponents.
• The Diamondbacks have lost four of their last five road games against NL Central opponents that held a winning record.
• The Cardinals have covered the run line in each of their last nine games against National League opponents following a win.
• The Diamondbacks have failed to cover the run line in each of their last five games following a loss.
• The Cardinals have led after 3 innings in each of their last three games as favorites against National League opponents.
• The Diamondbacks have trailed after 5 innings in seven of their last nine games against NL Central opponents.

Why the Arizona Diamondbacks will win

• The Diamondbacks have won five of their last six games as road underdogs against NL Central opponents following a loss.
• The Cardinals have lost each of their last three games as favorites against the Diamondbacks following a win.
• The Diamondbacks have covered the run line in eight of their last nine games as underdogs against NL Central opponents following a loss.
• The Cardinals have failed to cover the run line in nine of their last 11 games as home favorites against the Diamondbacks following a win.
• The Cardinals have trailed after 5 innings in each of their last three home games.

St. Louis Cardinals Player Prop Facts

• Brendan Donovan has recorded a Double in four of the Cardinals’ last five games as favorites.
• Willson Contreras has recorded at least one RBI in each of his last six appearances at Busch Stadium against NL opponents that held a winning record.
• Willson Contreras has recorded at least one Single in each of his last six appearances at Busch Stadium against opponents that held a winning record.
• Lars Nootbaar has scored at least one run in eight of his last nine appearances with the Cardinals as home favorites.
• Brendan Donovan has recorded at least one hit in each of the Cardinals’ last 11 games as home favorites against NL West opponents.
• Nolan Gorman has hit at least one home run in three of his six previous appearances in day games against NL West teams that held a winning record.
• Victor Scott II ranks T6th in the league in Steals (14) this season.

Arizona Diamondbacks Player Prop Facts

• Ketel Marte has hit a home run in each of his last four appearances against NL Central opponents that held a winning record.
• Ketel Marte has recorded at least one RBI in each of his last eight road appearances against NL Central opponents.
• Merrill Kelly has recorded five or more strikeouts in 10 of his last 11 appearances with the Diamondbacks as underdogs against NL Central opponents.
• Ketel Marte has scored at least one run in seven of his last eight appearances against NL Central opponents.
• Geraldo Perdomo has recorded at least one hit in each of the Diamondbacks’ last seven games as underdogs.
• Alek Thomas has recorded at least one Single in each of the Diamondbacks’ last six day games against NL opponents that held a winning record.
• Corbin Carroll ranks 6th amongst qualified players for Slugging Percentage (.579) this season.

Arizona Diamondbacks vs St. Louis Cardinals Prediction

The Diamondbacks are in a funk offensively and the Cardinals have been hit or miss lately. Kelly has been on fire, allowing 19 hits and five runs in his last 25.1 innings. Kelly has allowed eight runs in his last 37 innings. Liberatore has allowed 18 hits and six runs in his last 21.1 innings. Liberatore has a 1.80 ERA and .189 allowed batting average in 25 home innings. This feels like a low scoring game with two pitchers who are in fantastic form. Give me the under.