Arizona Diamondbacks vs St. Louis Cardinals Prediction 6/23/2026 Today’s MLB Picks

The Arizona Diamondbacks and the St. Louis Cardinals meet Tuesday in MLB action from Busch Stadium. We will look at this from a betting perspective and determine the best bets for this game. Here’s an Arizona Diamondbacks vs. St. Louis Cardinals prediction.

Starting Pitching Matchup

The Arizona Diamondbacks will send out Eduardo Rodriguez for the start here and Rodriguez is 6-2 with a 2.45 ERA and 65 strikeouts this season. Kyle Leahy will start for St. Louis and is 5-4 with a 4.63 ERA and 59 strikeouts this season.

Arizona Diamondbacks Recap

The Arizona Diamondbacks come into this game looking to shake off a 3-2 loss at the hands of St. Louis in Monday’s opener to sit at 39-39 this season. After this series, the Diamondbacks will head on the road for a series against the Tampa Bay Rays.

Diamondbacks Lose 3 In A Row

Going into Monday, Corbin Carroll has 77 hits including 16 doubles, 9 triples, 13 home runs and 42 RBIs. Ketel Marte has 76 hits with 16 doubles, 12 home runs and 46 RBIs and Geraldo Perdomo has 61 hits, with 10 doubles, 3 triples, 4 home runs and 27 RBIs as well this season. Nolan Arenado also has 58 hits with 12 doubles, 8 home runs and 31 RBIs and Jose Fernandez has 42 hits with 3 home runs and 15 RBIs this season. Ildemaro Vargas also has 63 hits with 10 doubles, 2 triples, 7 home runs and 42 RBIs.

St. Louis Cardinals Recap

The St. Louis Cardinals come into this game looking to add on to their win over the Diamondbacks from Monday’s opener to sit at 42-34 on the year. After this series, the Cardinals will take on the Miami Marlins in a series at home.

Cardinals Pick Up Back-To-Back Wins

Entering Monday, Jordan Walker leads the Cardinals with 85 hits, 16 doubles, 18 home runs and 58 RBIs while Alec Burleson has 84 hits with 19 doubles, 13 home runs and 55 RBIs. JJ Wetherholt has 74 hits with 12 home runs and 34 RBIs while Ivan Herrera has 73 hits with 13 doubles, 10 home runs and 38 RBIs. Nolan Gorman has 39 hits with 7 home runs and 26 RBIs this season. Masyn Winn’s added 62 hits with 11 doubles and 31 RBIs and Nathan Church has 47 hits with 5 home runs and 19 RBIs this season. 

Arizona Diamondbacks @ St. Louis Cardinals Betting Trends: June 23, 2026

• Probable Starting Pitcher: Kyle Leahy      Record this season: 5-4      ERA: 4.63
• Home Record: 2-3
• Last 5 against Diamondbacks: 0-0

Why the St. Louis Cardinals will win

• The home team has won each of the last eight games between the Diamondbacks and Cardinals.
• The Diamondbacks have lost each of their last six road games against teams that held a winning record.
• The Cardinals have won the first inning in three of their last four games.
• The Diamondbacks have trailed after 3 innings in each of their last nine games as underdogs against NL Central opponents.
• The Diamondbacks have trailed after 5 innings in each of their last 12 games as underdogs.

• Probable Starting Pitcher: Eduardo Rodriguez      Record this season: 6-2      ERA: 2.45
• Road Record: 2-1
• Last 5 against Cardinals: 1-0

Why the Arizona Diamondbacks will win

• The Diamondbacks have won each of their last four night games against NL Central opponents following a road loss.
• The Cardinals have lost five of their last six night games against the Diamondbacks following a win.
• The Cardinals have failed to cover the run line in each of their last 13 games as favorites against NL West opponents following a win.
• The Diamondbacks have covered the run line in each of their last six games against the Cardinals.
• The Diamondbacks have led after 3 innings in three of their last four games against the Cardinals.
• The Diamondbacks have led after 5 innings in six of their last seven night games against the Cardinals at Busch Stadium.

Total Runs Facts

• Each of the Cardinals’ last 10 games against NL West opponents have gone UNDER the total runs line.
• Each of the Diamondbacks’ last nine road games after playing the previous day have gone UNDER the total runs line.
• There has been no run scored during the first inning in each of the Diamondbacks’ last four games as road underdogs against NL Central opponents.
• There has been no run scored during the first inning in each of the Cardinals’ last four night games against NL West opponents.

St. Louis Cardinals Player Prop Facts

• Alec Burleson has hit a home run in four of the Cardinals’ last nine night games.
• Alec Burleson has recorded at least one hit in each of the Cardinals’ last 20 games as favorites.
• Ivan Herrera ranks 5th amongst qualified players for On Base Percentage (.406) this season.

Arizona Diamondbacks Player Prop Facts

• Nolan Arenado has hit a home run in three of his last five appearances against the Cardinals.
• Ildemaro Vargas has recorded at least one hit in each of his last 15 Tuesday appearances.
• Corbin Carroll is one of only two players to record 10+ Home Runs and 4+ Triples this season.

Matchup/League Facts

• The Cardinals rank 28th in the league for strikeouts this season (577).
• The Cardinals rank 4th in the league for strikeouts against this season (591).
• The Diamondbacks rank 1st in the league for triples this season (19).
• The Diamondbacks rank 30th in the league for strikeouts this season (540).

Arizona Diamondbacks vs. St. Louis Cardinals Prediction

I’m backing St. Louis here. I get the case to be made for either side in this game, but I think that the Cardinals are just playing the better baseball right now. Kyle Leahy isn’t my favorite starter in this Cardinal rotation, but I think he can hold down this Diamondbacks lineup that’s been hot and cold against righties in June, mostly cold though. I’ll back St. Louis at home here.

Chris Ruffolo's Pick: St. Louis -110