Arizona Diamondbacks vs Colorado Rockies Prediction 5/16/2026 Today’s MLB Picks

The Arizona Diamondbacks and the Colorado Rockies meet Saturday in MLB action from Coors Field. We will look at this from a betting perspective and determine the best bets for this game. Here’s an Arizona Diamondbacks vs. Colorado Rockies prediction.

Starting Pitching Matchup

The Arizona Diamondbacks will send out Eduardo Rodriguez for the start here and Rodriguez is 4-0 with a 2.25 ERA and 33 strikeouts this season. In his last five starts against the Rockies, Rodriguez is 3-0 with a 4.40 ERA and 29 strikeouts. Tomoyuki Sugano will start for Colorado here and is 3-3 with a 4.07 ERA and 24 strikeouts this season. This will be Sugano’s first career start against the Diamondbacks.

Arizona Diamondbacks Recap

The Arizona Diamondbacks come into this game looking to add on to their 9-1 win over Colorado to start the series to improve to 21-22 this season. After this series, the Diamondbacks will head home for a series against the Giants.

Diamondbacks Snap Two-Game Skid

Entering Friday, Corbin Carroll has 37 hits including 10 doubles, 4 triples, 5 home runs and 20 RBIs while Alek Thomas has logged 9 doubles with 2 home runs and 10 RBIs as well this season. Ketel Marte has 34 hits with 5 doubles, 5 home runs and 15 RBIs and Geraldo Perdomo has 29 hits, with 6 doubles, 3 triples, 2 home runs and 12 RBIs as well this season. Nolan Arenado also has 37 hits with 6 doubles, 6 home runs and 20 RBIs and Jose Fernandez has 29 hits with 3 home runs and 12 RBIs this season. Ildemaro Vargas also has 46 hits with 7 doubles, 2 triples, 7 home runs and 28 RBIs.

Colorado Rockies Recap

The Colorado Rockies come into this game looking to shake off a loss at the hands of Arizona on Friday to fall to 17-28 on the year. After this series, the Rockies will take on the Texas Rangers at home.

Rockies Lose 5 Of Last 6

Going into Friday, TJ Rumfield has 44 hits with 7 doubles, a triple, 6 home runs and 22 RBIs while Ezequiel Tovar has 29 hits with 8 doubles, a home run and 11 RBIs. Hunter Goodman’s added 37 hits with 8 doubles, 10 home runs and 18 RBIs and Jordan Beck has 10 RBIs as well on the year. Troy Johnston has 42 hits with 12 doubles, 2 home runs and 20 RBIs. Willi Castro also has 27 hits with 5 doubles, 2 home runs and 13 RBIs.

Arizona Diamondbacks @ Colorado Rockies Betting Trends: May 16, 2026

• Probable Starting Pitcher: Tomoyuki Sugano      Record this season: 3-3      ERA: 4.07
• Home Record: 2-2
• Last 5 against Diamondbacks: –

Why the Colorado Rockies will win

• The Diamondbacks have lost seven of their last eight games as road favorites after playing the previous day.
• The Rockies have won three of their last four games as underdogs against the Diamondbacks.
• The Diamondbacks have failed to cover the run line in each of their last 11 Saturday day games as favorites against National League opponents.
• The Rockies have covered the run line in each of their last six Saturday day home games against NL West opponents.
• The Diamondbacks have trailed after 3 innings in each of their last four road day games.
• The Diamondbacks have trailed after 5 innings in each of their last five road day games.

• Probable Starting Pitcher: Eduardo Rodriguez      Record this season: 4-0      ERA: 2.25
• Road Record: 1-0
• Last 5 against Rockies: 3-0

Why the Arizona Diamondbacks will win

• The Rockies have lost each of their last seven day games against NL West opponents following a loss.
• The Diamondbacks have won each of their last three games against National League opponents.
• The Rockies have failed to cover the run line in seven of their last eight home games.
• The Diamondbacks have covered the run line in eight of their last nine games against National League opponents following a road win.
• The Rockies have lost the first inning in four of their last five games.
• The Rockies have trailed after 3 innings in each of their last six games.
• The Rockies have trailed after 5 innings in each of their last 10 Saturday games against National League opponents that held a losing record.

Total Runs Facts

• Each of the Diamondbacks’ last six games against National League opponents have gone UNDER the total runs line.
• Six of the last seven games between the Diamondbacks and Rockies at Coors Field have gone UNDER the total runs line.
• The ‘Inning 1 OVER 0.5 runs’ market has hit in eight of the Rockies’ last nine day games against NL West opponents.
• The ‘Inning 1 OVER 0.5 runs’ market has hit in five of Eduardo Rodriguez’s last six road appearances as a starter.

Colorado Rockies Player Prop Facts

• Hunter Goodman has hit a home run in each of his last two appearances against NL West opponents.
• Brenton Doyle has recorded two or more hits in each of the Rockies’ last three day games against NL West opponents that held a losing record.
• Mickey Moniak ranks 2nd amongst qualified players for Slugging Percentage (.672) this season.

Arizona Diamondbacks Player Prop Facts

• Corbin Carroll has hit at least one home run in four of his last 10 appearances with the Diamondbacks as road favorites against NL West opponents.
• Gabriel Moreno has recorded two or more hits in each of his last six appearances against the Rockies.
• Eduardo Rodriguez has recorded a win in each of his four previous road appearances against NL West opponents that held a losing record.
• Ildemaro Vargas ranks 1st amongst qualified players for Batting Average (.347) this season.

Matchup/League Facts

• The Rockies rank 30th in the league for opponent batting average this season (.272).
• The Rockies rank 29th in the league for strikeouts against this season (426).
• The Diamondbacks rank 1st in the league for triples this season (12).
• The Diamondbacks rank 30th in the league for strikeouts this season (318).

Arizona Diamondbacks vs. Colorado Rockies Prediction

I’m on Arizona here. I just have no faith in the Rockies right now as I’m not sure I can trust this team and their pitching on any given night and while Coors Field is supposed to be an advantage for their offense, the Rockies looked lifeless offensively on Friday. Rodriguez has been arguably Arizona’s ace this season and I think the Diamondbacks back him up here. Give me Arizona.

Chris Ruffolo's Pick: Arizona -155