Houston Astros vs Cleveland Guardians Prediction 6/6/25 MLB Picks

The Houston Astros and Cleveland Guardians meet Friday in MLB action at Progressive Field. Here’s a Houston Astros vs Cleveland Guardians Prediction. This article will include a Houston Astros vs Cleveland Guardians Pick.

Houston Astros Betting Preview

The Houston Astros are 34-28 on the year and play the White Sox, Twins, and Athletics next. The Houston Astros are batting .252 on the season, have a .17 OBP, and a .391 slugging percentage. The Houston Astros’ pitching staff has a 3.56 ERA and a 1.16 WHIP. Jeremy Pena leads the Houston Astros with 75 hits and 31 RBI, while Jose Altuve and Isaac Paredes have combined for 120 hits and 60 RBI. 

Colton Gordon gets the ball for the Houston Astros, and he is 0-1 with a 5.95 ERA and 20 strikeouts this season. This will be Gordon’s first career game against the Cleveland Guardians.

Cleveland Guardians Betting Preview

The Cleveland Guardians are 32-28 on the year and play the Reds, Mariners, and Giants next. The Cleveland Guardians are batting .234 on the season, have a .305 OBP, and a .377 slugging percentage. The Cleveland Guardians’ pitching staff has a 3.99 ERA and a 1.38 WHIP. Jose Ramirez leads the Cleveland Guardians with 74 hits and 29 RBI, while Steven Kwan and Carlos Santana have combined for 124 hits and 50 RBI.

Logan Allen gets the ball for the Cleveland Guardians, and he is 3-3 with a 4.22 ERA and 38 strikeouts this season. Allen is 0-1 with a 5.40 ERA and 9 strikeouts in his career against the Houston Astros.

Why the Cleveland Guardians will win

• The Astros have lost eight of their last nine road games against American League opponents following a win.
• The Guardians have won five of their last six games against American League opponents following a loss.
• The Astros have failed to cover the run line in each of their last four games against American League opponents.
• The Guardians have covered the run line in each of their last four home games against American League opponents after playing the previous day.

Why the Houston Astros will win

• The Astros have won each of their last seven Friday games as underdogs against American League opponents.
• The Guardians have lost each of their last three games as home favorites against the Astros following a road loss.
• The Astros have covered the run line in each of their last 14 Friday games as road underdogs against American League opponents.
• The Guardians have failed to cover the run line in four of their last five night games against AL West opponents.
• The Guardians have trailed after 5 innings in each of their last five home games against opponents that held a winning record.
• The Guardians have trailed after 3 innings in four of their last five home games against AL West opponents.

Cleveland Guardians Player Prop Facts

• Jose Ramirez has hit a home run in three of the Guardians’ last four home games against AL West opponents.
• Jose Ramirez has scored at least one run in eight of the Guardians’ last nine games at Progressive Field.
• Carlos Santana has recorded at least one hit in each of his last 12 appearances with his team as a home favorite against AL West opponents.
• Carlos Santana has recorded a Single in each of his last eight home appearances against AL West opponents.
• Will Brennan has recorded at least one Double in each of his last three appearances with the Guardians as favorites against AL opponents.
• Nolan Jones has recorded at least one RBI in each of the Guardians’ last four games at Progressive Field.
• Jose Ramirez ranks T5th in the league in Hits (74) this season.

Houston Astros Player Prop Facts

• Isaac Paredes has hit at least one home run in three of the Astros’ last four road games against AL opponents.
• Jeremy Pena has recorded at least one RBI in each of the Astros’ last four games against AL Central opponents that held a winning record.
• Jose Altuve has recorded two or more hits in each of his last six appearances with the Astros as underdogs against the Guardians.
• Yordan Alvarez has recorded at least one Single in each of his last eight appearances in night games against AL Central teams that held a winning record.
• Jose Altuve has recorded at least one Double in each of his last four appearances with the Astros as underdogs against the Guardians.
• Yordan Alvarez has scored at least one run in each of his last six road appearances against AL opponents that held a winning record.
• Jeremy Pena ranks 9th amongst qualified players for Batting Average (.318) this season.

Houston Astros vs Cleveland Guardians Prediction

The Astros are playing the better baseball right now, but I’m rolling with the Guardians at home. Gordon isn’t off to the best start in his MLB career, allowing 24 hits and 13 runs in 19.2 innings. Gordon has allowed no less than three runs in all four of his starts. Allen hasn’t been anything to write home about, but his numbers are still better than Gordon’s, and he’s even better at home, where he has a 3.94 ERA in 16 innings. In a near pick’em spot, I’ll take the home team with the better pitcher. Give me the Guardians. 

Randy Chambers's Pick: Cleveland Guardians -112