Detroit Tigers vs Chicago White Sox Prediction 6/4/25 MLB Picks

The Detroit Tigers and the Chicago White Sox meet Wednesday in MLB action from Rate Field. We will look at this from a betting perspective and determine the best bets for this game. Here’s a Detroit Tigers vs. Chicago White Sox prediction.

Starting Pitching Matchup

The Detroit Tigers will send out Sawyer Gipson-Long to the mound here for his first major league start since the 2023 season. The Chicago White Sox did not have a starting pitcher announced at the time that this article was posted.

Detroit Tigers Recap

The Detroit Tigers come into this game looking to rebound from their 8-1 loss at the hands of the White Sox last time out to slip to 40-22 on the year. After this series, the Tigers will head home for an interleague series against the Chicago Cubs.

Tigers Win 7 Of Their Last 9 Games

Spencer Torkelson has 48 hits along with a .235 batting average, including a team-high 14 home runs, 14 doubles, and 42 RBIs. Kerry Carpenter also has 13 home runs and 27 RBIs, while Riley Greene has 62 hits with 13 doubles, 13 home runs, and 40 RBIs, but also has a team-high 78 strikeouts this season. Dillon Dingler has 6 home runs and 24 RBIs, and Zack McKinstry’s added 10 doubles, 4 triples, 3 home runs, and 19 RBIs of his own along with 47 hits this season. Javier Baez has added 46 hits and 10 doubles as well as 6 home runs and 29 RBIs this season.

Why the Detroit Tigers will win

• The White Sox have lost 21 of their last 22 night games against AL Central opponents.
• The Tigers have won each of their last nine games as favorites following a road loss.
• The Tigers have covered the run line in each of their last nine games against AL Central opponents following a road loss.
• The White Sox have failed to cover the run line in each of their last five night games against AL Central opponents following a win.

Detroit Tigers Player Prop Facts

• Colt Keith has recorded at least one RBI in each of his last five road appearances against the White Sox.
• Parker Meadows has recorded a Double in three of his last four appearances against AL Central opponents.
• Wenceel Perez has scored a run in each of his last eight road appearances against AL opponents that held a losing record.
• Wenceel Perez has recorded at least one hit in each of his last 10 appearances in night games.
• Kerry Carpenter has hit at least one home run in four of the Tigers’ last six games against the White Sox.
• Colt Keith has recorded at least one Single in seven of his last eight road appearances against AL Central opponents that held a losing record.

Chicago White Sox Recap

The Chicago White Sox come into this game looking to build on their win over the Tigers in Tuesday’s matchup to improve to 19-42 on the year. After this series, the White Sox will square off in a division home series against the Kansas City Royals.

White Sox Snap Four-Game Losing Skid

Lenyn Sosa leads the White Sox with 55 hits, including 10 doubles and 17 RBIs. Andrew Benintendi has 29 hits, including 6 home runs, 22 RBIs, and a .242 batting average, while Miguel Vargas has a team-high 15 doubles, 8 home runs, and 26 RBIs. Brooks Baldwin has also added 16 RBIs, while Luis Robert Jr. has a team-high 21 stolen bases along with 20 RBIs so far this season. Andrew Vaughn has 5 home runs and 19 RBIs as well as 8 doubles this season.

Why the Chicago White Sox will win

• The underdogs have won three of the Tigers’ last four games.
• The Tigers have lost six of their last nine games as favorites against American League opponents.
• The White Sox have covered the run line in each of their last six Wednesday games against the Tigers.
• The Tigers have failed to cover the run line in five of their last six night games against American League opponents that held a losing record.

Chicago White Sox Player Prop Facts

• Luis Robert has recorded at least one hit in each of his last 12 Wednesday night appearances against AL teams that held a winning record.
• Andrew Vaughn has hit a home run in four of his last 12 home appearances against AL Central opponents.
• Andrew Benintendi has recorded at least one Single in each of his last six Wednesday appearances.
• Andrew Vaughn has recorded two RBIs in each of his last three home appearances against the Tigers.
• Austin Slater has recorded a Double in four of his last five appearances against AL Central opponents.
• Andrew Benintendi has scored a run in four of his last five home appearances against opponents that held a winning record.

Total Runs Facts

• Each of the White Sox’s last five home games after playing the previous day have gone OVER the total runs line.
• Each of the Tigers’ last four night games against AL Central opponents have gone OVER the total runs line.

Detroit Tigers vs. Chicago White Sox Prediction

I’m on the Tigers here. I get the case to be made for the White Sox after taking it to the Tigers on Tuesday, and Gipson-Long making his first start at this level since 2023. However, sustained success and the Chicago White Sox are not two things that have consistently gone together in recent years, and I think the Tigers take it to the White Sox once again here. Give me the Tigers in this one.