Washington Nationals vs Seattle Mariners Prediction 5/29/25 MLB Picks

In this article, we will formulate a Nationals vs Mariners prediction for this MLB game on Thursday, May 29, at T-Mobile Park in Seattle, Washington. Let’s take a look at the prediction for this MLB matchup.

Washington Nationals Betting Preview

The Washington Nationals (25-30, 12-16 Away) swept the Orioles and Phillies, lost the series to the San Francisco Giants, and opened this one against the Seattle Mariners with a 9-1 defeat. However, the Nats responded in style with a 9-0 win last night. In that victory, James Wood led the offense with three RBI, while Trevor Williams got the win after allowing no runs on three hits with two strikeouts and no walks across 6.0 innings of work.

This season, the Nationals average 4.27 runs per game (15th in the MLB) on a .241/.308/.392 triple-slash. When it comes to pitching, the Nationals’ staff has a 5.04 ERA (26th) and 1.40 WHIP (25th). James Wood leads the Nationals with a .287 batting average, 15 home runs, and 40 RBI this season.

MacKenzie Gore will take the mound for the Nats on Thursday. The 26-year-old left-hander has a 2-5 record in 11 starts this year with a 3.47 ERA and 1.25 WHIP in 62.1 innings.

Seattle Mariners Betting Preview

The Seattle Mariners (30-24, 14-12 Home) swept the San Diego Padres, defeated the Chicago White Sox, and then lost to the Houston Astros. The Mariners opened this series against the Washington Nationals on high with a 9-1 win, but succumbed to a 9-0 loss in Game 2. George Kirby took the loss after allowing six runs on seven hits with four strikeouts and two walks in 5.0 innings.

This year, the Mariners average 4.57 runs per game (10th in the MLB) on a .238/.324/.398 triple-slash. When it comes to pitching, the Mariners’ staff has a 3.74 ERA (14th) and 1.31 WHIP (19th). Cal Raleigh leads the Mariners with a .258 batting average, 19 home runs, and 37 RBI this season.

The projected starting pitcher for the Mariners is Emerson Hancock, who is 2-2 in eight starts this season, with a 5.95 ERA and 1.65 WHIP in 39.1 innings.

Total Runs Facts

• Each of the Mariners’ last six games against NL East opponents have gone OVER the total runs line.
• Seven of the Nationals’ last eight games against American League opponents have gone OVER the total runs line.
• The ‘Inning 1 OVER 0.5 runs’ market has hit in five of the Mariners’ last six games as favorites.
• The ‘Inning 1 UNDER 0.5 runs’ market has hit in four of the Nationals’ last five night games against American League opponents.

Matchup/League Facts

• The Mariners rank 4th in the league for walks this season (210).
• The Mariners are one of only four teams in the league to rank top 10 in both steals and home runs this season.
• The Nationals rank 25th in the league for runs allowed this season (282).
• The Nationals rank 7th in the league for steals this season (53).

Nationals vs Mariners Prediction

The Nationals won seven of the previous ten H2H encounters, including six of the last eight. Each of the past three meetings went Over, and I am going with another Over in this one. Even though I am leaning toward the Nationals, as I prefer Gore over Hancock, I am choosing Over because of the latter. Hancock allowed 11 runs in his last three starts, and in seven of his eight starts this season, the game produced 8+ runs. We need eight combined runs on Thursday, so I am backing the Over.