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Cincinnati Reds vs Kansas City Royals Prediction 5/28/25 MLB Picks

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Kansas City Royals (29-27) vs Cincinnati Reds (28-28)

May 28, 2025 at 07:40 PM EDT

The Line: Betting Odds: Kansas City Royals -102 / Cincinnati Reds -118 — Over/Under: 7.5

(Get latest betting odds)

In this article, we will formulate a Reds vs Royals prediction for this MLB game on Wednesday, May 28, at Kauffman Stadium in Kansas City, Missouri. Let’s take a look at the prediction for this MLB matchup.

Cincinnati Reds Betting Preview

The Cincinnati Reds (28-28, 14-14 Away) lost the series to the Pirates and Cubs, but beat the Kansas City Royals in the opening two games of the current series, and will try to sweep it on Wednesday. In Tuesday’s 7-2 victory, Elly De La Cruz led the offense with two solo homers, while Brady Singer got the win after allowing two runs on seven hits with three strikeouts and one walk across 7.0 innings of work.

This season, the Reds average 4.64 runs per game (9th in the MLB) on a .247/.322/.397 triple-slash. When it comes to pitching, the Reds’ staff has a 3.82 ERA (15th) and 1.20 WHIP (9th). Elly De La Cruz leads the Reds with a .256 batting average, 11 home runs, and 40 RBI this season.

Hunter Greene will take the mound for the Reds on Wednesday. The 25-year-old right-hander has a 4-2 record in nine starts this year with a 2.54 ERA and 0.85 WHIP in 49.2 innings.

Kansas City Royals Betting Preview

The Kansas City Royals (29-27, 17-11 Home) came back home from two road series; they beat the San Francisco Giants and lost to the Minnesota Twins. The Royals opened this series against Cincy with a 7-4 loss and followed it with a 7-2 defeat last night. Kansas City has now lost four of the previous five games. On Tuesday, Daniel Lynch IV pitched for 2.2 innings in a no-decision, allowing one run on three hits with four strikeouts and one walk. Taylor Clarke took the loss.

This year, the Royals average 3.33 runs per game (27th in the MLB) on a .246/.300/.363 triple-slash. When it comes to pitching, the Royals’ staff has a 3.10 ERA (2nd) and 1.18 WHIP (6th). Vinnie Pasquantino leads the Royals with a .255 batting average, eight home runs, and 30 RBI this season.

The projected starting pitcher for the Royals is Noah Cameron, who is 1-1 in three starts this season, with a 0.93 ERA and 0.67 WHIP in 19.1 innings.

Total Runs Facts

  • Eight of the Reds’ last nine games as favorites have gone UNDER the total runs line.
  • Each of the Royals’ last five night games as underdogs have gone UNDER the total runs line.
  • The ‘Inning 1 UNDER 0.5 runs’ market has hit in each of the Royals’ last eight night games at Kauffman Stadium.
  • The ‘Inning 1 UNDER 0.5 runs’ market has hit in each of the Reds’ last five night games against American League opponents.

Matchup/League Facts

  • The Royals rank 2nd in the league for ERA this season (3.17).
  • The Royals rank 3rd in the league for strikeouts against this season (393).
  • The Reds rank 6th in the league for doubles this season (99).
  • The Reds rank 7th in the league for RBIs this season (250).

Reds vs Royals Prediction

The Reds won six of the previous ten H2H encounters, but the Royals were better in three of the last five. Although both opening games of the series went Over, I am going with Under in this one because of the starters. Hunter Greene allowed more than two runs only twice this season, and he surrendered three runs in his last three starts. Noah Cameron, on the other hand, is experiencing a fantastic rookie season, registering all three quality starts and allowing just two runs along the way. Expect a great pitching battle here and a lot of good defense.

Oliver Zivic's Pick: Under 7.5

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