Pittsburgh Pirates vs Arizona Diamondbacks Prediction 5/26/25 MLB Picks

The Pittsburgh Pirates are visiting the Arizona Diamondbacks on Monday, May 26th at the Chase Field in the opening game of this series. We will look at this from a betting perspective and determine the best bets for this game. Here’s a Pittsburgh Pirates vs Arizona Diamondbacks Prediction. We will examine:

The Arizona Diamondbacks’ recent form and player performance

The Pittsburgh Pirates’ recent form and player performance

Recent betting trends and streaks involving the Arizona Diamondbacks

Recent betting trends and streaks involving the Pittsburgh Pirates

Recent betting trends in games played between the Pittsburgh Pirates vs Arizona Diamondbacks

A summary that ties it all together and produces a favorable betting outcome for the Pittsburgh Pirates vs Arizona Diamondbacks game

Arizona Diamondbacks Preview

The Arizona Diamondbacks have a 26-27 record this season and are sitting in 4th place in the NL West. The Diamondbacks have a 13-13 home record and are 22-26 in over/under. They are coming off a 3-4 road defeat by the Cardinals and have five consecutive losses. Under is 3-1-1 in their last 5 games, and they are playing the Braves and the Nationals next.

The Diamondbacks have a .255 batting average this season, a .333 OBP, and a .447 slugging percentage. Arizona’s pitching staff has a 4.67 ERA and 1.32 WHIP. Corbin Carroll leads the Diamondbacks with 58 hits and a team-high 15 home runs, while Geraldo Perdomo is the team’s best hitter with a .304 batting average. Eugenio Suarez leads the team in RBI, with 40.

Ryne Nelson (R) will take the mound for the Diamondbacks, and he has a 1-1 record, 4.60 ERA, and 1.15 WHIP. He has a 4.41 ERA in his six home starts, and he has been in good form lately, with 3 earned runs in 9.1 innings pitched in his last two starts. He struggled in his only start against the Pirates last season, as he gave up 4 runs in 5 innings of work.

Pittsburgh Pirates Preview

The Pittsburgh Pirates have a 19-35 record this season and are sitting in last place in the NL Central. They have a 6-19 road record, and are 20-31 in over/under. They are coming off a 5-6 home defeat by the Brewers, which ended their previous two-game winning streak. Over is 3-1 in their last 4 games are playing the Padres and the Astros next.

The Pirates have a .224 batting average this season, a .304 OBP, and a .331 slugging percentage. Pittsburgh’s pitching staff has a 4.00 ERA and 1.27 WHIP. Ke’Bryan Hayes leads the Pirates with 44 hits, while Bryan Reynolds leads the team with 27 RBI. Andrew McCutchen is the team’s best hitter with a .260 batting average.

Andrew Heaney (L) will take the mound for the Pirates, and he has a 3-3 record, 2.91 ERA, and 1.13 WHIP. He has been better on the road with a 2.45 ERA in four road starts, and he has been in excellent form lately, with just two earned runs in 10 innings pitched across his last two starts. Andrew Heaney has a record of 1-0 with an ERA of 7.71 and 6 strikeouts in 2 appearances against the Diamondbacks in his career.

Why the Arizona Diamondbacks will win

• The Pirates have lost 15 of their last 16 games against NL West opponents.
• The Diamondbacks have won 10 of their last 11 home games against NL Central opponents following a loss.
• The Pirates have failed to cover the run line each of their last six road games against National League opponents that held a losing record.
• The Diamondbacks have covered the run line in nine of their last 10 night games against the Pirates following a loss.
• The Diamondbacks have led after 3 innings in each of their last four games as home favorites against National League opponents.
• The Diamondbacks have led after 5 innings in 11 of their last 12 games against opponents that held a losing record.
• The Pirates have lost the first inning in four of their last five road games against NL West opponents.

Why the Pittsburgh Pirates will win

• The Diamondbacks have lost each of their last four games as home favorites following a road loss.
• The Pirates have won eight of their last 12 games as underdogs following a home loss.
• The underdogs have covered the run line in seven of the Diamondbacks’ last eight games.
• The Diamondbacks have failed to cover the run line in each of their last six games as home favorites following a road loss.
• The Diamondbacks have trailed after 3 innings in six of their last eight games against NL Central opponents.
• The Diamondbacks have trailed after 5 innings in each of their last five home games against NL Central opponents.

Total Runs Facts

• Each of the Pirates’ last four road games after playing the previous day have gone UNDER the total runs line.
• Eight of the Diamondbacks’ last 10 home games have gone UNDER the total runs line.
• The ‘Inning 1 OVER 0.5 runs’ market has hit in eight of the Pirates’ last nine games as road underdogs against NL West opponents.
• The ‘Inning 1 UNDER 0.5 runs’ market has hit in each of the Diamondbacks’ last five night games against NL Central opponents.

Matchup/League Facts

• The Diamondbacks rank 1st in the league for doubles this season (107).
• The Diamondbacks rank 4th in the league for slugging percentage this season (.447).
• The Pirates rank 30th in the league for runs scored this season (164).
• The Pirates rank 30th in the league for doubles this season (62).

Pittsburgh Pirates vs Arizona Diamondbacks Prediction

The Diamondbacks are 7-3 in their last 10 meetings against the Pirates, and are 4-2 in their last 6 meetings in Arizona. Over is 4-1 in their last 5 meetings.

In this Pittsburgh Pirates vs Arizona Diamondbacks Prediction, the Diamondbacks are coming as -185 home favorites. The Dbacks are rightfully favored, as they have a far better overall record this season, and the Pirates are one of the weakest road teams in the league. But the Dbacks have been mediocre at home, they have the 5th-worst bullpen in the league, and the Pirates have the pitching advantage in this game. Pirates’ bats have come alive recently, as they have scored 5+ runs in three of their last four games, so I think they are a live dog in this game, as the Dbacks don’t deserve to be -185 favorites. I will take a stab with the Pittsburgh Pirates for plus money in this one.