San Diego Padres vs Toronto Blue Jays Prediction 5/20/25 MLB Picks

The San Diego Padres and Toronto Blue Jays meet Tuesday in MLB action at Rogers Centre. Here’s a San Diego Padres vs Toronto Blue Jays Prediction. This article will include a San Diego Padres vs Toronto Blue Jays Pick.

San Diego Padres Betting Preview

The San Diego Padres are 27-18 on the year and play the Braves, Marlins, and Pirates next. The San Diego Padres are batting .261 on the season, have a .328 OBP, and a .396 slugging percentage. The San Diego Padres pitching staff has a 3.39 ERA and a 1.17 WHIP. Fernando Tatis Jr. leads the San Diego Padres with 52 hits and 27 RBI, while Manny Machado and Luis Arraez have combined for 99 hits and 35 RBI. 

Dylan Cease gets the ball for the San Diego Padres, and he is 1-2 with a 4.60 ERA and 58 strikeouts this season. Cease is 1-0 with a 0.69 ERA and 18 strikeouts in his career against the Toronto Blue Jays.

Toronto Blue Jays Betting Preview

The Toronto Blue Jays are 22-24 on the year and play the Rays, Rangers, and Athletics next. The Toronto Blue Jays are batting .249 on the season, have a .318 OBP, and a .380 slugging percentage. The Toronto Blue Jays pitching staff has a 4.31 ERA and a 1.25 WHIP. Bo Bichette leads the Toronto Blue Jays with 57 hits and 22 RBI, while Vladimir Guerrero Jr. and Alejandro Kirk have combined for 88 hits and 38 RBI.

Chris Bassitt gets the ball for the Toronto Blue Jays, and he is 3-2 with a 3.16 ERA and 55 strikeouts this season. Bassitt is 1-3 with a 4.44 ERA and 32 strikeouts in his career against the San Diego Padres.

Why the Toronto Blue Jays will win

• The Padres have lost seven of their last eight games against American League opponents following a loss.
• The Blue Jays have won five of their last six home games against National League opponents.
• The Blue Jays have covered the run line in each of their last six night games at Rogers Centre following a home loss.
• The Padres have failed to cover the run line in six of their last seven road games against American League opponents that held a losing record.
• The Padres have trailed after 5 innings in each of their last three games against AL East opponents that held a losing record.

Why the San Diego Padres will win

• The Padres have won five of their last six night games against teams that held a losing record.
• The Blue Jays have lost four of their last five games at Rogers Centre against teams that held a winning record.
• The Blue Jays have failed to cover the run line in each of their last six Tuesday night home games against NL West opponents.
• The Padres have covered the run line in six of their last seven road games following a loss.
• The Padres have led after 3 innings in three of their last four road games against opponents that held a losing record.
• The Padres have led after 5 innings in six of their last seven games against opponents that held a losing record.

Toronto Blue Jays Player Prop Facts

• Chris Bassitt has recorded a win in three of his last four home appearances against NL opponents.
• Alejandro Kirk has recorded at least one RBI in six of his last seven appearances at Rogers Centre against NL opponents that held a winning record.
• Chris Bassitt has recorded seven or more strikeouts in each of his last four appearances against NL opponents.
• Alejandro Kirk has recorded at least one hit in each of his last eight appearances at Rogers Centre against NL opponents that held a winning record.
• Myles Straw has recorded at least one Single in seven of his last eight appearances in night games against NL teams that held a winning record.
• Anthony Santander has scored at least one run in each of his last six home appearances against NL opponents that held a winning record.
• Daulton Varsho has hit at least one home run in three of his last four home appearances after not playing the previous day.
• Anthony Santander has recorded a Double in three of the Blue Jays’ last four games against NL opponents at Rogers Centre.

San Diego Padres Player Prop Facts

• Manny Machado has recorded at least one hit in each of his last nine road appearances against AL East opponents that held a losing record.
• Luis Arraez has recorded at least one Single in each of the Padres’ last seven night games.
• Manny Machado has scored at least one run in eight of the Padres’ last nine road games.
• Jackson Merrill has hit a home run in two of his last three appearances against AL East opponents.
• Manny Machado has recorded a Double in three of the Padres’ last four road games against opponents that held a losing record.
• Manny Machado has recorded at least one RBI in four of the Padres’ last five road games against opponents that held a losing record.
• Dylan Cease has recorded six or more strikeouts in six of his last seven appearances against AL East opponents.

San Diego Padres vs Toronto Blue Jays Prediction

The Padres are the better team, and they’re due for a breakout performance offensively, but they’ve scored a combined three runs in their last three games. Cease has been better lately, but he’s been hittable this season overall with a 4.60 ERA and 1.34 WHIP. In 19.2 innings, Cease has a 6.41 ERA and a .253 allowed batting average. Bassitt has simply been the better pitcher this season with his 3.16 ERA and 1.27 WHIP, and he has a 2.05 ERA in 22 home innings. We’re getting the Blue Jays at home with the better starting pitching option, while the Padres are in a funk offensively. Give me the Blue Jays.