Cleveland Guardians vs Minnesota Twins Prediction 5/19/25 MLB Picks

The Cleveland Guardians and Minnesota Twins meet Monday in MLB action at Target Field. Here’s a Cleveland Guardians vs Minnesota Twins Prediction. This article will include a Cleveland Guardians vs Minnesota Twins Pick.

Cleveland Guardians Betting Preview

The Cleveland Guardians are 25-21 on the year and play the Tigers, Dodgers, and Angels next. The Cleveland Guardians are batting .233 on the season, have a .307 OBP, and a .380 slugging percentage. The Cleveland Guardians’ pitching staff has a 4.14 ERA and a 1.41 WHIP. Steven Kwan leads the Cleveland Guardians with 56 hits and 17 RBI, while Jose Ramirez and Gabriel Arias have combined for 85 hits and 42 RBI. 

Logan Allen gets the ball for the Cleveland Guardians, and he is 2-2 with a 3.70 ERA and 31 strikeouts this season. Allen is 2-0 with a 2.04 ERA and 14 strikeouts in his career against the Minnesota Twins.

Minnesota Twins Betting Preview

The Minnesota Twins are 26-21 on the year and play the Royals, Rays, and Mariners next. The Minnesota Twins are batting .242 on the season, have a .310 OBP, and a .386 slugging percentage. The Minnesota Twins pitching staff has a 3.20 ERA and a 1.14 WHIP. Ty France leads the Minnesota Twins with 42 hits and 23 RBI, while Trevor Larnach and Byron Buxton have combined for 83 hits and 50 RBI.

Bailey Ober gets the ball for the Minnesota Twins, and he is 4-1 with a 3.72 ERA and 40 strikeouts this season. Ober is 3-2 with a 2.05 ERA and 48 strikeouts in his career against the Cleveland Guardians.

Why the Minnesota Twins will win

• The Twins have won each of their last nine home games.
• The Guardians have lost each of their last four games.
• The Twins have covered the run line in each of their last six home games against American League opponents.
• The Guardians have failed to cover the run line in seven of their last eight road games against American League opponents that held a winning record.
• The Guardians have trailed after 5 innings in four of their last five road games against American League opponents.
• The Guardians have trailed after 3 innings in four of their last five road games against American League opponents that held a winning record.

Why the Cleveland Guardians will win

• The Guardians have won 10 of their last 11 games as underdogs against the Twins.
• The Twins have lost each of their last three games as favorites against AL Central opponents.
• The Guardians have covered the run line in each of their last six games as underdogs against the Twins.
• The Twins have failed to cover the run line in nine of their last 10 games against the Guardians at Target Field following a loss.
• The Guardians have led after 3 innings in three of their last four games as road underdogs against AL Central opponents.

Minnesota Twins Player Prop Facts

• Ty France has recorded at least one RBI in five of his last six appearances at Target Field against AL opponents that held a winning record.
• Ty France has recorded at least one Single in seven of the Twins’ last eight games against AL Central opponents.
• Bailey Ober has recorded five or more strikeouts in eight of his last nine home appearances against AL opponents.
• Willi Castro has recorded at least one hit in each of his last 11 appearances with the Twins as home favorites against AL Central opponents.
• Byron Buxton has hit a home run in four of the Twins’ last seven games against AL opponents.
• Bailey Ober has recorded a win in each of his last four appearances with the Twins as home favorites against AL Central opponents.
• Trevor Larnach has scored at least one run in seven of the Twins’ last eight games.

Cleveland Guardians Player Prop Facts

• Carlos Santana has recorded an RBI in four of the Guardians’ last five games as underdogs.
• Steven Kwan has scored at least one run in each of the Guardians’ last five night games against AL opponents that held a winning record.
• Jose Ramirez has recorded at least one Single in 14 of his last 15 appearances with the Guardians as underdogs.
• Jose Ramirez has recorded at least one hit in each of his last 11 appearances after playing the previous day.
• Austin Hedges has hit a home run in each of his last two appearances with the Guardians as road underdogs against the Twins.
• Jose Ramirez ranks T7th in the league in Steals (12) this season.

Cleveland Guardians vs Minnesota Twins Prediction

The Guardians are coming off a rough week, which includes four straight losses and an offense that can’t produce consistently. So, while Allen has been strong this season, which includes five earned runs in his last 15.2 innings, it’s hard to take the Guardians seriously during this streak. The Twins have lost one game since May 3 and are absolutely dealing pitching-wise. Ober has allowed five earned runs in his last 15.2 innings, and he has a 2.53 ERA in 21.1 home innings. I’m not stepping in front of the Twins as long as the tickets keep cashing.