Chicago White Sox vs Chicago Cubs Prediction 5/18/25 MLB Picks

In this article, we will formulate a White Sox vs Cubs prediction for this MLB game on Sunday, May 18, at Wrigley Field in Chicago, Illinois. Let’s take a look at the prediction for this MLB matchup.

Chicago White Sox Betting Preview

The Chicago White Sox (14-32, 5-20 Away) won the series against the Marlins and Reds, which was the first time this season they won back-to-back sets. Still, the White Sox returned to losing ways in this rivarly series against the Cubs, losing the opening two games, 13-3 and 7-3. In Saturday’s 7-3 defeat, Sean Burke took the loss after allowing six runs (five earned) on seven hits with four strikeouts and five walks in 4.2 innings.

This year, the White Sox average 3.38 runs per game (28th in the MLB) on a .217/.290/.329 triple-slash. When it comes to pitching, the White Sox’s staff has a 4.15 ERA (22nd) and 1.39 WHIP (23rd). Miguel Vargas leads the White Sox with a .237 batting average, five home runs, and 20 RBI this season.

The projected starting pitcher for the White Sox is Jonathan Cannon, who is 2-4 in seven starts this season, with a 3.60 ERA and 1.36 WHIP in 50.0 innings.

Chicago Cubs Betting Preview

The Chicago Cubs (27-19, 14-10 Home) responded to series losses against the Giants and Mets with a win over the Miami Marlins. They then beat the city rivals White Sox in the first two games of the current series. In last night’s 7-3 victory, Pete Crow-Armstrong and Miguel Amaya led the team with two RBI apiece, while Matthew Boyd got the win after allowing three runs on four hits with eight strikeouts and no walks across 6.0 innings of work.

This season, the Cubs average 5.71 runs per game (3rd in the MLB) on a .253/.329/.440 triple-slash. When it comes to pitching, the Cubs’ staff has a 4.00 ERA (18th) and 1.30 WHIP (18th). Pete Crow-Armstrong leads the Cubs with a .285 batting average, 12 home runs, and 38 RBI this season.

Colin Rea will take the mound for the Cubs on Sunday. The 34-year-old right-hander has a 3-0 record in six starts this year with a 2.48 ERA and 1.21 WHIP in 36.1 innings.

Total Runs Facts

• Seven of the Cubs’ last eight games as favorites against American League opponents have gone OVER the total runs line.
• The ‘Inning 1 OVER 0.5 runs’ market has hit in eight of the White Sox’s last 10 day games.
• The ‘Inning 1 OVER 0.5 runs’ market has hit in four of the last five day games between the White Sox and Cubs.

Matchup/League Facts

• The Cubs rank 2nd in the league for triples this season (12).
• The Cubs rank 2nd in the league for steals this season (57).
• The White Sox rank 29th in the league for RBIs this season (150).
• The White Sox rank 29th in the league for slugging percentage this season (.330).

White Sox vs Cubs Prediction

The Cubs have dominated this series in the last couple of years, winning nine of the previous ten. The Cubs are on a seven-game winning streak against the White Sox, and I think they will get another one on Sunday, but I am opting for the Under instead. Jonathan Cannon allowed only four runs in his last three starts, all of which were quality starts. Colin Rea, on the other hand, has the lowest ERA of the Cubs’ starters, and he has already registered four shutouts this season. Expect a low-scoring affair after a couple of Overs.