Houston Astros vs Milwaukee Brewers Prediction 5/5/25 MLB Picks

Milwaukee Brewers Betting Preview

The Milwaukee Brewers are 17-18 on the year and play the Rays, Guardians, and Twins next. The Milwaukee Brewers are batting .238 on the season, have a .316 OBP, and a .356 slugging percentage. The Milwaukee Brewers' pitching staff has a 4.32 ERA and a 1.34 WHIP. Brice Turang leads the Milwaukee Brewers with 41 hits and 16 RBI, while Jackson Chourio and Sal Frelick have combined for 73 hits and 33 RBI.

Tobias Myers gets the ball for the Milwaukee Brewers, and he is 0-0 with a 5.14 ERA and 6 strikeouts this season. This will be Myers’ first career game against the Houston Astros.

Why the Milwaukee Brewers will win

• The Astros have lost each of their last 10 games at American Family Field against teams that held a losing record.
• The Brewers have won nine of their last 10 games against American League opponents following a home win.
• The Astros have failed to cover the run line each of their last six road games against National League opponents that held a losing record.
• The Brewers have covered the run line in six of their last seven night games against AL West opponents.
• The Brewers have led after 5 innings in five of their last six night games against American League opponents that held a winning record.
• The Astros have trailed after 3 innings in five of their last six games.

Why the Houston Astros will win

• The Astros have won six of their last seven games as road underdogs following a loss.
• The Brewers have lost four of their last five games as favorites against AL West opponents following a home win.
• The Astros have covered the run line in each of their last six games as underdogs after playing the previous day.
• The Brewers have failed to cover the run line in five of their last six night games against the Astros following a win.

Milwaukee Brewers Player Prop Facts

• Rhys Hoskins has hit a home run in each of the Brewers' last two home games against AL opponents that held a winning record.
• Jackson Chourio has recorded an RBI in four of the Brewers' last five games against AL West opponents at American Family Field.
• Rhys Hoskins has scored a run in five of the Brewers' last six games at American Family Field against opponents that held a winning record.
• Brice Turang has recorded at least one Single in nine of the Brewers' last 10 home games against AL opponents.
• Christian Yelich has recorded at least one hit in each of his last 11 appearances at American Family Field against AL opponents that held a winning record.

Houston Astros Player Prop Facts

• Jose Altuve has hit a home run in three of the Astros' last eight games as underdogs.
• Jake Meyers has recorded at least one RBI in four of his five previous appearances against the Brewers.
• Jake Meyers has scored a run in five of his last six appearances in night games against NL teams that held a losing record.
• Victor Caratini has recorded at least one Single in each of his last six appearances with his team as an underdog against NL Central opponents.
• Jeremy Pena has recorded at least one hit in each of the Astros' last eight games.

Houston Astros vs Milwaukee Brewers Prediction

I’m siding with the over in this series opener. The Astros and Brewers are capable offensively, and this isn’t a great pitching matchup. Blanco is better than what he’s shown up to this point, but he’s still allowed 23 hits and 16 runs in 28.1 innings. In 6.2 road innings this season, Blanco has a 9.45 ERA and .345 allowed batting average. Myers has pitched just seven innings this season and has still allowed six hits and four runs while walking seven. I expect a high-scoring game with two respectable lineups taking advantage of two struggling pitchers. Give me the over.