Houston Astros vs Chicago White Sox Prediction 5/3/25 MLB Picks

Chicago White Sox Betting Preview

The Chicago White Sox are 9-23 on the year and play the Royals, Marlins, and Reds next. The Chicago White Sox are batting .216 on the season, have a .294 OBP, and a .333 slugging percentage. The Chicago White Sox pitching staff has a 4.01 ERA and a 1.35 WHIP. Lenyn Sosa leads the Chicago White Sox with 29 hits and 8 RBI, while Miguel Vargas and Brooks Baldwin have combined for 46 hits and 26 RBI.

Davis Martin gets the ball for the Chicago White Sox, and he is 1-3 with a 3.24 ERA and 21 strikeouts this season. This will be Martin’s first career game against the Houston Astros.

Why the Chicago White Sox will win

• The Astros have lost four of their last five games as road favorites against American League opponents.
• The White Sox have won five of their last six games as home underdogs against AL West opponents following a win.
• The White Sox have covered the run line in 14 of their last 15 games as underdogs against AL West opponents following a home win.
• The Astros have failed to cover the run line each of their last six road games against teams that held a losing record.
• The White Sox have led after 5 innings in three of their last four games.
• The Astros have lost the first inning in three of their last four road games against AL Central opponents that held a losing record.
• The White Sox have led after 3 innings in three of their last four home games.

Why the Houston Astros will win

• The Astros have won each of their last four day games following a loss.
• The White Sox have lost 12 of their last 14 games at Rate Field against American League opponents that held a winning record.
• The Astros have covered the run line in 10 of their last 11 day games against American League opponents following a road loss.
• The White Sox have failed to cover the run line in five of their last six games at Rate Field against American League opponents that held a winning record.
• The Astros have led after 5 innings in three of their last four day games against the White Sox at Rate Field.
• The White Sox have trailed after 3 innings in three of their last four games at Rate Field against American League opponents that held a winning record.

Chicago White Sox Player Prop Facts

• Luis Robert has hit a home run in four of the White Sox's last seven games against the Astros at Rate Field.
• Luis Robert has recorded at least one RBI in five of the White Sox's last six games as underdogs.
• Luis Robert has scored at least one run in five of his last six appearances against AL opponents that held a winning record.
• Andrew Vaughn has recorded a Single in five of the White Sox's last six home games.
• Luis Robert has recorded at least one hit in each of the White Sox's last seven games.

Houston Astros Player Prop Facts

• Christian Walker has recorded a Double in three of the Astros' last four road games against AL Central opponents that held a losing record.
• Yainer Diaz has hit a home run in each of the Astros' last two games against the White Sox.
• Victor Caratini has scored at least one run in five of his last six appearances in day games.
• Yordan Alvarez has recorded at least one RBI in six of his last seven appearances against the White Sox after playing the previous day.
• Mauricio Dubon has recorded at least one hit in each of his last eight road appearances against AL Central opponents that held a losing record.
• Jeremy Pena has recorded at least one Single in 13 of the Astros' last 14 games as favorites against AL opponents.

Houston Astros vs Chicago White Sox Prediction

Give the White Sox credit as they’ve won two straight Ames and their offense has come to life. Add that to Martin pitching well, posting a 3.24 ERA and 1.32 WHIP on the season, and you can make a case for a third straight win. Still, as I’ve said time and time again over the last three years, I have no use for the White Sox and their constant losing. Two wins don’t move the needle much when you consider the White Sox have 245 losses since the 2023 season. The Astros are comfortably the better side, and Brown has allowed 20 hits and three runs in his last 31 innings. Brown had an ERA of 0.87 in the month of April. Absolutely, dealing, folks. Give me the Astros and the RL for max betting value.