Tampa Bay Rays vs San Diego Padres Prediction 4/27/25 MLB Picks

Rays Win 4th In A Row

Jake Mangum has 23 hits, including 4 doubles and 7 RBIs, with a team-high 8 stolen bases, while Jonathan Aranda has 25 hits with a team-high 8 doubles, 4 home runs, and 13 RBIs. Brandon Lowe has 20 hits with 4 homers and 14 RBIs as well, while Junior Caminero has 25 hits with 5 doubles, a team-high 5 home runs, and 12 RBIs. Yandy Diaz has 28 hits with 7 doubles, 3 homers, and 13 RBIs, and Kameron Misner has 23 hits with 7 doubles, 3 homers, and 11 RBIs as well, while Christopher Morel has a team-high 35 strikeouts this season. Jose Caballero has 7 stolen bases, while Taylor Walls and Jonny DeLuca each have 4 stolen bases as well this season.

Why the Tampa Bay Rays will win

• The Rays have won each of their last four games as underdogs.
• The Padres have lost each of their last four games as favorites against American League opponents.
• The Rays have covered the run line in seven of their last eight games as underdogs after playing the previous day.
• The Padres have failed to cover the run line in each of their last five games as favorites against American League opponents.

Tampa Bay Rays Player Prop Facts

• Brandon Lowe has hit a home run in four of his last eight appearances in day games against NL teams that held a winning record.
• Brandon Lowe has recorded at least one RBI in four of his last five appearances in day games against teams that held a winning record.
• Danny Jansen has scored a run in eight of his last nine appearances in day games against NL teams that held a winning record.
• Yandy Diaz has recorded at least one Single in 11 of his last 12 appearances against NL opponents that held a winning record.
• Brandon Lowe has recorded at least one hit in each of his eight previous appearances in day games against NL West teams that held a winning record.
• Jonathan Aranda ranks 7th amongst qualified players for On Base Percentage (.419) this season.

San Diego Padres Recap

The San Diego Padres come into this game looking to snap out of their funk after another sluggish showing in Saturday’s loss, falling to 17-10 on the year. After this series, the Padres will welcome the rival San Francisco Giants to town for a series.

Padres Drop Three In A Row, Score 1 Run Combined

Manny Machado has 28 hits, including a team-high 10 doubles and 6 stolen bases, while Fernando Tatis Jr. has 35 hits with a team-high 8 home runs and 18 RBIs, along with 7 stolen bases of his own this season. Luis Arraez has added 25 hits with 3 doubles, while Jackson Merrill’s added 14 hits with 3 home runs and 10 RBIs as well. Xander Bogaerts also has 8 doubles and 4 stolen bases this season. Gavin Sheets also has 4 doubles, 3 home runs, and 12 RBIs as well this season.

Why the San Diego Padres will win

• The Padres have won each of their last seven day games against teams that held a losing record.
• The Rays have lost each of their last six day games following a win.
• The Padres have covered the run line each of their last six day games against teams that held a losing record.
• The Rays have failed to cover the run line in each of their last six day games following a win.

San Diego Padres Player Prop Facts

• Fernando Tatis Jr. has recorded a Double in four of the Padres' last five home games against the Rays.
• Gavin Sheets has scored at least one run in seven of his last eight appearances in day games against AL East teams that held a losing record.
• Fernando Tatis Jr. has recorded an RBI in five of the Padres' last six games as home favorites against AL East opponents.
• Jose Iglesias has recorded at least one hit in each of his last 12 appearances in day games against AL teams that held a losing record.
• Luis Arraez has recorded at least one Single in each of his last 10 appearances against AL East opponents.
• Jackson Merrill has hit a home run in each of his last two appearances with the Padres against AL opponents.
• Fernando Tatis Jr. ranks 4th amongst qualified players for Slugging Percentage (.634) this season.

Total Runs Facts

• Each of the Padres' last six day games as favorites have gone UNDER the total runs line.
• Four of the Rays' last five day games after playing the previous day have gone OVER the total runs line.

Tampa Bay Rays vs. San Diego Padres Prediction

I’m on the over here. I get any sort of hesitation, as we’ve seen low-scoring games in this series. However, Zack Littell, despite back-to-back quality starts, still isn’t a starter I trust right now, as this Padres lineup is still far too talented to continue struggling like this. On the other side, Randy Vasquez is starting to show signs of regression, and the Rays got to him for 9 runs in his lone start against them last season. I think we'll see some offensive fireworks to close out the series. Give me the over here.