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Washington Nationals vs Pittsburgh Pirates Prediction 4/15/25 MLB Picks

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Pittsburgh Pirates (6-11) vs Washington Nationals (6-10)

Game Info: Tuesday, April 15, 2025 at 6:40 pm (PNC Park)

The Line: Betting Odds: Pittsburgh Pirates -125 / Washington Nationals +105 — Over/Under: 8.5

(Get latest betting odds)


In this article, we will formulate a Washington Nationals vs Pittsburgh Pirates Prediction for this MLB game on Tuesday, April 15th, at PNC Park. To formulate this prediction, we will look at: 

-The Nationals’ recent form and recent player performance 

-The Pirates’ recent form and recent player performance

-Recent Betting trends and streaks involving Washington

-Recent Betting trends and streaks involving Pittsburgh

-Recent betting trends in games played between Washington and Pittsburgh

-A summary that ties it all together produces a favorable betting outcome for Today’s Game between the Nationals and Pirates.

Offensive Breakout for Pirates

It was an offensive breakout for the Pirates, scoring ten runs on the way to the victory. Enmanuel Valdez finished with two hits and three runs driven in. The Pirates are averaging 3.13 runs, while their pitching is giving up 4.88 runs per game. The offene is ranked 29th in the league, and this team just isn’t very talented at the plate; there isn’t any other way to put it. Bryan Reynolds has hit two home runs and driven in six RBIs. 

Mitch Keller, who has a 1-1 record and an ERA of 4.34, will start for the Pirates. He struggled two games ago against the Yankees, but he bounced back in the last game against the St. Louis Cardinals, going 7.1 innings and giving up four hits and one run. 

Why the Pirates Will Beat the Nationals

  • The Nationals have lost each of their last 14 night games against National League opponents following a road loss.
  • The Pirates have won seven of their last eight home games against teams that held a losing record.
  • The Nationals have failed to cover the run line in each of their last five games following a road loss.
  • The favorites have covered the run line in each of the Pirates’ last four games.
  • The Nationals have lost the first inning in each of their last three games against NL Central opponents that held a losing record.
  • The Nationals have trailed after 3 innings in each of their last six games as road underdogs.
  • The Nationals have trailed after 5 innings in each of their last six games as road underdogs.

Nationals Need Better Pitching

The Nationals are going to need better pitching after what happened on Monday. Brad Lord went 4.1 innings, giving up six hits and four runs. Eduardo Salazar also went one inning, giving up five hits and three runs. Nathaniel Lowe was the top offensive player, finishing with a hit and one RBI. 

The Nationals are averaging 4.67 runs, while their pitching is giving up 5.33 runs per game. The offense actually can’t be overlooked as they are ranked 9th, but the pitching overall has been a major issue. Getting the start for Washington will be Jake Irvin, who sits with a 0-0 record and an ERA of 5.63. Against the LA Dodgers, he went six innings, giving up four hits and four runs. 

Total Runs Facts

  • Each of the Nationals’ last nine night games against National League opponents have gone OVER the total runs line.
  • Five of the Pirates’ last six games as favorites against the Nationals have gone OVER the total runs line.
  • The ‘Inning 1 OVER 0.5 runs’ market has hit in each of the Pirates’ last six home games against NL East opponents.
  • The ‘Inning 1 OVER 0.5 runs’ market has hit in each of the Nationals’ last four night games at PNC Park.

Washington Nationals vs Pittsburgh Pirates Prediction

Give me the Pirates here. Mitch Keller sure looked impressive in his last start, and even against a good offense, he’s going to have another strong start. For Jake Irvin, he gave up four hits and four runs in his last start, and even against a bad offense, he’s not going to be good. The Pirates aren’t going to need many runs here, but they are going to come out on top. Back the Pirates on the money line to come out ahead. 

Shane Mickle's Pick: Pirates ML

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