Cleveland Guardians vs Baltimore Orioles Prediction 4/15/25 MLB Picks

The Cleveland Guardians are visiting the Baltimore Orioles on Tuesday, April 15th, at the Oriole Park at Camden Yards. We will look at this from a betting perspective and determine the best bets for this game. Here’s a Cleveland Guardians vs Baltimore Orioles Prediction. We will examine:

The Baltimore Orioles’ recent form and player performance

The Cleveland Guardians’ recent form and player performance

Recent betting trends and streaks involving the Baltimore Orioles

Recent betting trends and streaks involving the Cleveland Guardians

Recent betting trends in games played between the Cleveland Guardians vs. Baltimore Orioles

A summary that ties it all together and produces a favorable betting outcome for the Cleveland Guardians vs Baltimore Orioles game

Baltimore Orioles Preview

The Baltimore Orioles have a 6-9 record this season and are sitting in the last place of the AL East. The Orioles have a 2-3 home record and 9-5 in over/under. They are coming off a 6-7 home defeat by the Toronto Blue Jays and are 1-3 in their last 4 games. The Orioles have a .235 batting average this season, .302 OBP, and .383 slugging percentage. Baltimore’s pitching staff has a 3.60 ERA and 1.35 WHIP.  Adley Rutschman leads the Orioles with 14 hits, while Cedric Mullins leads the team in RBI with 16, in OBP with .414, and in home runs with 3.

Charlie Morton (R) will take the mound for the Orioles, and he has been terrible this season with a 0-3 record, 8.78 ERA, and 1.88 WHIP. He has 4+ earned runs in each of his starts this season, and in his only start against the Guardians last season, he had zero earned runs in 7 innings of work.  

Cleveland Guardians Preview

The Cleveland Guardians have an 8-7 record this season and are sitting in the second place of the AL Central. The Guardians have a 3-6 road record and 7-7 in over/under. They are coming off a 2-4 home defeat by the Kansas City Royals and saw their previous five-game winning streak getting snapped. The Guardians have a .222 batting average this season, .306 OBP, and .373 Slugging percentage. Cleveland’s pitching staff has a 4.57 ERA and 1.44 WHIP. Steven Kwan leads the Guardians with 19 hits and a team-high .322 batting average. Kyle Manzardo leads the team with 11 RBI.

Logan Allen (L) will take the mound for the Guardians, and he has a 0-1 record, 3.60 ERA, and 1.80 WHIP. In his only start against the Orioles last season, he got torched for 6 earned runs in just 3 innings pitched.

Why the Baltimore Orioles will win

• The home team has won seven of the Guardians’ last eight games.
• The Guardians have lost each of their last four road games against AL East opponents.
• The Guardians have failed to cover the run line in each of their last six games as underdogs against AL East opponents.
• The favorites have covered the run line in each of the Guardians’ last four games.
• The Orioles have led after 3 innings in each of their last five night games against AL Central opponents.
• The Guardians have trailed after 5 innings in each of their last four games as underdogs.

Why the Cleveland Guardians will win

• The Guardians have won each of their last 11 Tuesday games against teams that held a losing record.
• The Orioles have lost each of their last five games as favorites against AL Central opponents.
• The Guardians have covered the run line each of their last six road games against teams that held a losing record.
• The Orioles have failed to cover the run line each of their last six home games against teams that held a winning record.
• The Guardians have led after 3 innings in seven of their last eight games against opponents that held a losing record.
• The Guardians have led after 5 innings in each of their last six road games against American League opponents that held a losing record.
• The Guardians have won the first inning in each of their last three night games against opponents that held a losing record.

Total Runs Facts

• Each of the Orioles’ last five games as favorites against American League opponents have gone OVER the total runs line.
• Four of the Guardians’ last five games as underdogs against the Orioles have gone OVER the total runs line.
• The ‘Inning 1 OVER 0.5 runs’ market has hit in each of the Orioles’ last seven games as favorites.
• The ‘Inning 1 UNDER 0.5 runs’ market has hit in seven of the Guardians’ last eight games as underdogs.

Cleveland Guardians vs Baltimore Orioles Prediction

In their seven overall meetings last season, the Guardians led the Orioles 4-3 wins, winning the only series in Baltimore by 2-1 wins. The over is 4-0 in their last 4 meetings.

In this Cleveland Guardians vs Baltimore Orioles Prediction, Baltimore is coming as -140 home favorites. Perhaps the wrong team is favored in this spot, as the Guardians have more wins this season and are coming into this matchup in far better form. With that being said, I don’t trust any of those pitchers at this point, and the only way I can look at this matchup is from a total perspective. Fade both pitchers and take the over in the first 5 innings in this one.