Chicago White Sox vs San Diego Padres Prediction MLB Picks 9/21/24

White Sox Headed For Unfortunate History

Entering Friday, Gavin Sheets has a .238 batting average and a .309 OBP along with 24 doubles and 45 RBIs while Andrew Vaughn has 19 homers and 67 RBIs and Andrew Benintendi has 19 home runs and 60 RBIs with Vaughn logging 29 doubles as well as a team-high 132 hits.

Why the Chicago White Sox will win

• The Padres have lost six of their last eight games as favorites following a home win.
• The road team has won four of the last five games between the White Sox and Padres.
• The Padres have failed to cover the run line in each of their last eight games as favorites following a home win.
• The White Sox have covered the run line in each of their last five games following an extra innings loss.

San Diego Padres Recap

The San Diego Padres come into this game looking to build on their victory over the White Sox, albeit a narrow one, from Friday’s opener. The win put the Padres on the right path to build on their series wins over the Houston Astros and San Francisco Giants over the last week.

Padres Inching Closer To Playoffs

Going into Friday’s opener, Jurickson Profar has 151 hits along with a .283 batting average and 27 doubles with 23 homers and 83 RBIs. Jake Cronenworth has 78 RBIs while Fernando Tatis Jr. has belted 19 home runs, 46 RBIs, and 103 hits as well this season. Manny Machado has 157 hits, 29 home runs, and 104 RBIs but also has 114 strikeouts while Ha-Seong Kim has 94 hits with 3 triples, 16 doubles, 11 home runs, 47 RBIs, and a team-high 22 stolen bases. Jackson Merrill has also chipped in 24 home runs, 86 RBIs, and 28 doubles with 6 triples this season.

Why the San Diego Padres will win

• The White Sox have lost each of their last 10 night games against National League opponents that held a winning record.
• The Padres have won seven of their last eight night games against AL Central opponents that held a losing record.
• The White Sox have failed to cover the run line in 10 of their last 11 games against National League opponents after playing the previous day.
• The Padres have covered the run line in four of their last five games as home favorites following an extra-innings win.

White Sox vs. Padres Prediction

I’m on the Padres in this one. Hopefully, San Diego can open it up a bit more here as they should’ve been ahead by a lot more than a 3-2 final score that we got on Friday. Chris Flexen’s struggled this year, and the White Sox have only managed to win 3 games with Flexen as a starter. Perez has been a nice acquisition for the Padres and San Diego’s won the majority of Perez’s starts in a Padre uniform. I’ll side with San Diego here.