Ohio State Buckeyes defensive tackle John Walker (55) pursues USC Trojans quarterback Jayden Maiava (14) during the NCAA football game at Los Angeles Memorial Coliseum on Oct. 31, 2026. Ohio State lost 30-18.
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Oregon vs Ohio State Prediction 11/7/2026 Today’s College Football Picks

Pick details

Oregon vs Ohio State Odds and Matchup Info
MATCHUP Oregon Ducks Ohio State Buckeyes
Team Records 5-3 6-2
Spread +7.5 -110 -7.5 -110
Moneyline +245 -305
Total Over 46.5 (-110) Under 46.5 (-110)
Where Ohio Stadium, Columbus, OH
When Saturday, November 7, 2026
Time 03:30 PM EST
TV CBS

Oregon vs Ohio State Prediction

In this Oregon vs Ohio State prediction, Ohio State is coming as -7.5 home favorites. Ohio State has been the better team this season, having a better overall record and has been undefeated at home. They have also been a top-20 team in the entire country both on the offensive and the defensive end, having a dominating +21.1 point differential and have been very good in limiting turnovers. On the flip side, Oregon has been up and down lately, with a struggling offense that has produced 17 points or less in three of their last four games and that is not a good sign when you are about to visit the #11 team in the entire nation. The line is fair, so I will lay the -7.5 points with Ohio State at home in this one.

Ohio State Buckeyes Preview

Ohio State has a 6-2 record and a 4-1 record in the Big Ten and Rank 11th in the Current AP poll. They are coming off a 18-30 road loss against USC and will face Northwestern and Nebraska next.

Offensively, Ohio State averages 36.6 points per game, ranking 19th in the nation, while defensively, they allow 15.5 points per game, which is 13th. Ohio State averages 474.8 total yards per game (315.3 passing and 159.5 rushing), while allowing 273.5 total yards per game (95.8 rushing and 177.8 passing). They average 70.1 plays per game and 6.8 yards per play on offense, while allowing 61.1 plays per game and 4.5 yards per play on defense. Ohio State averages 24.5 first downs per game on offense and 15.8 first downs per game on defense. They have turned the ball over 1.1 times per game and are forcing 1.4 turnovers per game.

Julian Sayin leads Ohio State with 2,007 passing yards with 68.2% completed passes and 19 touchdowns. Bo Jackson leads the team in rushing yards with 637, while Jeremiah Smith has a team-high 1,067 receiving yards and 62 receptions. Defensively, Payton Pierce has a team-high 43 total tackles (16 of them solo), while Kenyatta Jackson leads the team with 3.0 sacks.

Oregon Ducks Preview

Oregon has a 5-3 record and a 3-2 record in the Big Ten. They are coming off a 26-34 home win against Northwestern and will face Michigan and Michigan State next.

Offensively, Oregon averages 33.2 points per game, ranking 38th in the nation, while defensively, they allow 21.4 points per game, which is 47th. Oregon averages 425.4 total yards per game (285.0 passing and 140.4 rushing), while allowing 341.8 total yards per game (133.8 rushing and 208.0 passing). They average 69.3 plays per game and 6.1 yards per play on offense, while allowing 66.1 plays per game and 5.2 yards per play on defense. Oregon averages 20.1 first downs per game on offense and 17.8 first downs per game on defense. They have turned the ball over 1.6 times per game and are forcing 1.5 turnovers per game.

Dylan Raiola leads Oregon with 1,097 passing yards with 66.2% completed passes and 9 touchdowns. Jordon Davison leads the team in rushing yards with 439, while Dakorien Moore has a team-high 545 receiving yards and 41 receptions. Defensively, Koi Perich has a team-high 53 total tackles (28 of them solo), while Matayo Uiagalelei leads the team with 6.5 sacks.

Oregon Ducks @ Ohio State Buckeyes Betting Trends: Week 10

 

Why the Ohio State Buckeyes will win

  • Ohio State has won each of its last 10 home games against non-AP-ranked teams.
  • Ohio State has covered the spread in eight of its last nine November games as a home favorite against non-AP-ranked teams.
  • Oregon has failed to cover the spread in each of its last four November games as a road underdog.
  • Oregon has lost the first half in each of its last four November road games against top-15 AP-ranked teams.

Why the Oregon Ducks will win

  • Oregon has won 13 of its last 14 games in November.
  • Oregon has covered the spread in four of its last five games in November.
  • Ohio State has failed to cover the spread in each of its last three games as a favorite against non-AP-ranked teams.

Total Points Facts

  • Seven of Ohio State’s last eight home games against non-AP-ranked teams have gone OVER the total points line.
  • Six of Oregon’s last seven games as an underdog have gone OVER the total points line.

Ohio State Buckeyes Player Prop Facts

  • Julian Sayin has recorded a 120.0+ passer rating in 21 consecutive games – longest streak in the FBS.

Oregon Ducks Player Prop Facts

  • Heading into Week 10, Dakorien Moore leads Oregon for receptions (41) this season.

Matchup/League Facts

  • Ohio State ranks T2nd among FBS teams for 4th down conversion percentage against this season (25.0).
  • Ohio State ranks T5th among FBS teams for Q1 points per game this season (11.1).
  • Oregon ranks 8th among FBS teams for red zone percentage this season (94.3).
  • Oregon ranks 12th among FBS teams for H2 points per game this season (18.0).

Nikos Lagouretos's Pick: Ohio State -7.5

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