Nov 10, 2025; Evanston, Illinois, USA; Northwestern Wildcats forward Nick Martinelli (2) drives to the basket against the Cleveland State Vikings during the second half at Welsh-Ryan Arena. Mandatory Credit: David Banks-Imagn Images
David Banks-Imagn Images

Virginia vs Northwestern Prediction 11/21/2025 Today’s College Basketball Picks

Pick details

MATCHUP Virginia Cavaliers Northwestern Wildcats
Team Records 4-0 4-0
Spread -4.5 -108 +4.5 -112
Moneyline -192 +160
Total Over 145.5 (-112) Under 145.5 (-108)
Where Colonial Hall, White Sulphur Springs, WV
When Friday, November 21, 2025
Time 05:00 PM EST
TV CBSSN

The Virginia Cavaliers and Northwestern Wildcats meet Friday in the college basketball action at the Colonial Hall. Here’s a Virginia vs Northwestern Prediction. This article will include a Virginia vs Northwestern Pick.

Virginia Cavaliers Betting Preview


The Virginia Cavaliers beat Hampton and Marshall, and they play Butler next. Virginia has won 10 of its last 16 games.

The Virginia Cavaliers are averaging 121 points on 50 percent shooting and allowing 82 points on 34.9 percent shooting. Thijs De Ridder is averaging 17.3 points and 6 rebounds, while Malik Thomas is averaging 12 points and 2.8 assists. Sam Lewis is the third double-digit scorer and Chance Mallory is grabbing 4 rebounds. The Virginia Cavaliers are shooting 38.8 percent from beyond the arc and 66 percent from the free throw line. The Virginia Cavaliers are allowing 28.9 percent shooting from deep and are grabbing 55.3 rebounds per game.

Northwestern Wildcats Betting Preview


The Northwestern Wildcats beat Cleveland State and DePaul, and they play South Carolina next. Northwestern has won 8 of its last 11 games.

The Northwestern Wildcats are averaging 84.3 points on 52.2 percent shooting and allowing 60.3 points on 36.3 percent shooting. Nick Martinelli is averaging 20.5 points and 6.5 rebounds, while Arrinten Page is averaging 16 points and 8.3 rebounds. Jayden Reid is the third double-digit scorer and Tre Singleton is grabbing 4.3 rebounds. The Northwestern Wildcats are shooting 40 percent from beyond the arc and 69.1 percent from the free throw line. The Northwestern Wildcats are allowing 29.7 percent shooting from deep and are grabbing 34.5 rebounds per game.

Why the Northwestern Wildcats will win

  • Northwestern has won each of its last 12 Friday games against non-Conference opponents.
  • Virginia has lost each of its last three games played at neutral venues.
  • Virginia has lost the first half in each of its last three games against the Big Ten Conference at neutral venues.

Why the Virginia Cavaliers will win

  • Virginia has won each of its last four games.
  • Northwestern has lost three of its last four games against the Atlantic Coast Conference.

Total Points Facts

  • Each of Virginia’s last 15 games at a neutral venue have produced a total of 143 or fewer points.
  • Each of Northwestern’s last 14 games against non-AP-ranked opponents at a neutral venue have produced a total of 142 or fewer points.

Matchup/League Facts

  • Northwestern ranks 11th among Division 1 teams for turnovers per game this season (8.8).
  • Northwestern ranks 15th among Division 1 teams for opponent points per game this season (60.3).
  • Virginia ranks 9th among Division 1 teams for offensive rating this season (134.7).
  • Virginia ranks 9th among Division 1 teams for defensive rating this season (91.3).

Virginia vs Northwestern Prediction


Virginia is probably the more talented team and should have the crowd advantage with it being in West Virginia. However, Northwestern isn’t going to be scared of the moment, as this program has improved over the years and is usually known for its physical defense. Through a few games, Northwestern has shown an offensive spark and if those outside shots are falling, this could get interesting. I don’t see either team pulling away too badly. Expect this to come down to the last five minutes. I want the points in my back pocket.

Randy Chambers's Pick: Northwestern +4.5

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