Vanderbilt vs Wake Forest Prediction 12/21/2025 Today’s College Basketball Picks

The Vanderbilt Commodores and the Wake Forest Demon Deacons meet Sunday in college basketball action from LJVM Coliseum in Winston-Salem. Here’s a Vanderbilt vs Wake Forest prediction. We will look at this from a betting perspective and determine the best Vanderbilt vs Wake Forest pick. We will examine the recent form and player performances for both teams, as well as the recent betting trends and streaks pertaining to this matchup. As we conclude, we will tie it all together with a summary that produces a sensible pick for a favorable betting outcome in this game.

Vanderbilt Commodores Betting Preview

The Commodores are on a great run over 11 games so far. The first six outings were all wins over Lipscomb, Central Florida, Eastern Kentucky, AR-Pine Bluff, Texas Southern and Western Kentucky. Vanderbilt followed that up with wins over VCU, Saint Mary’s, SMU, Central Arkansas and Memphis. That gives the Commodores a perfect 11-0 record so far this season.

In the Memphis matchup on Wednesday, the Commodores entered the second half with a 28-22 advantage but eventually had to go to overtime to power out a 77-70 win in the end. Tops in scoring was Duke Miles with 22 points, four rebounds and five assists. Tyler Tanner added 16 points with seven rebounds and three assists while Jalen Washington had 14 points and six boards.

Wake Forest Demon Deacons Betting Preview

Over on the Wake Forest side, they opened up the year at 3-2 overall with wins over American, Morehead State and UMass Lowell. The Deacons otherwise lost to Michigan and Texas Tech. Since then it’s been a 6-1 run with a loss to Oklahoma among wins over Memphis, Campbell, Northeastern, West Virginia, Queens U and Longwood. That gives Wake Forest a 9-3 record in their first 12 games so far this year.

In the Longwood game Wednesday, the Deacons were in trouble on a 34-30 halftime deficit. Wake Forest hit a 41-34 run the rest of the way however, leading to a 71-68 win in the end. Juke Harris was tops on 19 points with eight rebounds and two assists while Nate Calmese had 12 points and two boards. Myles Colvin had 11 points with five rebounds and three assists as well.

Vanderbilt Commodores @ Wake Forest Demon Deacons Betting Trends: December 21, 2025

Why the Wake Forest Demon Deacons will win

• Wake Forest has won 13 of its last 14 day games against non-Conference opponents at Lawrence Joel Veterans Memorial Coliseum.
• Vanderbilt has lost four of its last five games following an overtime win.

Why the Vanderbilt Commodores will win

• Vanderbilt has won each of its last 11 games against non-AP-ranked opponents.
• Wake Forest has lost 14 of its last 15 games against AP-ranked opponents.
• Wake Forest has lost the first half in each of its last seven games against the Southeastern Conference.

Vanderbilt vs Wake Forest Prediction

I’ll try Vanderbilt in this one. The Commodores need a better effort than they got versus Memphis, though. Vanderbilt shot a dismal 32.3 percent from the field and just 19.4 percent (6-of-31) from outside in that one, coughing up 18 turnovers and getting outscored in the paint 34-24 along the way. Still, it turned into a win and Vanderbilt’s record is still spotless. The Commodores have 77 or more points in every game so far, with 83 or more in 10 of 11 games.

As for Wake Forest, they had a scare of their own versus a pesky Longwood team this week. The Deacons shot 40.7 percent from the field in that one and 20.8 percent (5-of-24) from outside while getting outmuscled on the boards 37-30. Wake has 68 or more points in every game this season themselves, so they’re scoring pretty well overall also.

Andrew Jett's Pick: Vanderbilt Commodores -5.5