UIC vs Charlotte Prediction 12/21/2025 Today’s College Basketball Picks

The UIC Flames and the Charlotte 49ers meet Sunday in college basketball action from the Halton Arena. We will look at this from a betting perspective and determine the best bets for this game. Here’s a UIC Flames vs. Charlotte 49ers prediction.

UIC Flames Recap

The UIC Flames come into this game looking to bounce back from a 60-54 loss at the hands of Northern Iowa last time out to sit at 4-7 on the year.

Flames Lose 5 In A Row

Ahmad Henderson II leads the Flames in scoring and assists with 14.2 PPG and 2.9 APG while Andy Johnson has 13.5 PPG with 2.6 RPG and 2.2 APG as the only other double-digit scorer for UIC so far this season. Rashund Washington Jr. has 9.4 PPG with 5 RPG and Mekhi Lowery has 8.7 PPG with a team-high 6.3 RPG and 2.7 APG to lead the Flames in rebounding. Josiah Hammons has 8.3 PPG and Jayce Nathaniel has 7.9 PPG with 5.5 RPG as well on the year. As a team, UIC is averaging 75.7 PPG on 43.8% shooting from the field, 30.6% from three and 77.1% from the foul line so far this season.

Charlotte 49ers Recap

The Charlotte 49ers come into this game looking to add on to their 81-67 win over Lafayette last time out to sit at 5-7 this season. After this game, Charlotte will take on Temple at home.

49ers Snap Two-Game Slide

Ben Bradford leads Charlotte in scoring with 13.5 PPG along with 3 RPG and 2.3 APG while Anton Bonke has 10.6 PPG with a team-high 8.8 RPG to lead the 49ers in rebounding as the only other double-digit scorer for Charlotte up to this point in the year. Dezayne Mingo has 9.2 PPG with 3.4 RPG and a team-high 3.7 APG to lead the 49ers in assists so far this year and Damoni Harrison has 8.4 PPG as well on the year. As a team, Charlotte is averaging 70.8 PPG on 44.7% shooting from the field, 34.9% from three and 66.7% from the foul line this season.

UIC Flames @ Charlotte 49ers Betting Trends: December 21, 2025

Why the Charlotte 49ers will win

• UIC has lost each of its last five games.
• Charlotte has won 20 of its last 25 games against non-Conference opponents at Halton Arena.
• UIC has lost the first half in four of its last five games against non-Conference opponents.

Why the UIC Flames will win

• Charlotte has lost each of its last six day games against non-Conference opponents.
• Charlotte has lost the first half in each of its last nine day games.

Matchup/League Facts

• Charlotte ranks 359th among Division 1 teams for pace this season (64.2).
• Charlotte ranks 18th among Division 1 teams for opponent free throw percentage this season (65.6%).
• UIC ranks 31st among Division 1 teams for free throw percentage this season (77.1%).

UIC Flames vs. Charlotte 49ers Prediction

I’m on Charlotte in this one. I get the case to be made for UIC here but Charlotte hasn’t been as bad as I thought they’d be coming into the year and the 49ers have actually done a good job when they’ve been on their home floor. UIC is not a team I’m going out of my way to back, especially on the road as the Flames’ lack of consistent offense continues to come back and bite this team so I’ll lay it with Charlotte in this one.

Chris Ruffolo's Pick: Charlotte -2.5