Nov 24, 2025; Las Vegas, Nevada, USA; Syracuse Orange forward William Kyle III (42) drives to the hoop past Houston Cougars forward Joseph Tugler (11) during the second half of a 2025 Players Era Festival group play game at MGM Grand Garden Arena. Mandatory Credit: Stephen R. Sylvanie-Imagn Images
Stephen R. Sylvanie-Imagn Images

Syracuse vs Iowa State Prediction 11/26/25 College Basketball Picks Today

Pick details

Syracuse (4-2) Iowa State (6-0)

01:00 PM EST

The Line: Betting Odds: Iowa State -9.5 — Over/Under: 157.5

(Get latest betting odds)


In this article, we will formulate a Syracuse vs Iowa State Prediction for this College Basketball game on Wednesday, November 26th. Let’s take a look at the prediction for this College Basketball matchup.

Iowa State Cyclones Preview


Iowa State has a 6-0 record this season and are in 5th place in the Big 12 conference. They are 4-2 ATS, 4-2 in Over/Under and have a 3-0 home record and a 0-0 away record. Iowa State is coming off a 78-60 home win against Creighton and will face Alcorn State, Purdue and Iowa next.

Offensively, Iowa State averages 90.5 points per game, which ranks 8th in the nation, while defensively, they allow 65.2 points per game (55th). The Cyclones shoot with 52.0% from the field (45th), and with 33.3% from beyond the arc (120th). They shoot with 77.8% from the free throw line (64th), and grab 37.8 rebounds per game (103rd), while dishing out 17.2 assists per game (33rd) and committing 12 turnovers per game (170th).

Tamin Lipsey leads Iowa State in scoring, with an average of 18.4 points and 5.2 assists per game. Joshua Jefferson follows with 18.3 points and 8.2 rebounds per game, while Milan Momcilovic adds 15.7 points per game.

Syracuse Orange Preview


Syracuse has a 4-2 record this season and are in 6th place in the ACC conference. They are 4-2 ATS, 2-4 in Over/Under and have a 3-0 home record and a 0-0 away record. Syracuse is coming off a 71-60 home loss against Kansas and will face Tennessee, Saint Joseph’s and Hofstra next.

Offensively, Syracuse averages 76.7 points per game, which ranks 202nd in the nation, while defensively, they allow 60.3 points per game (13th). The Orange shoot with 47.0% from the field (107th), and with 27.3% from beyond the arc (330th). They shoot with 77.8% from the free throw line (64th), and grab 37.2 rebounds per game (103rd), while dishing out 15.3 assists per game (128th) and committing 12 turnovers per game (170th).

Donnie Freeman leads Syracuse in scoring, with an average of 17.8 points and 5.3 rebounds per game. Kiyan Anthony follows with 12.5 points per game, while Naithan George adds 10.3 points and 3.5 assists per game.

Syracuse Orange @ Iowa State Cyclones Betting Trends: November 26, 2025


Why the Iowa State Cyclones will win

  • Syracuse has lost each of its last nine day games against AP-ranked opponents.
  • Iowa State has won each of its last seven day games against non-Conference opponents.
  • Iowa State has won the first half in eight of its last nine games against non-AP-ranked opponents.

Why the Syracuse Orange will win

  • Iowa State has lost three of its last four games against the Atlantic Coast Conference.
  • Iowa State has lost the first half in each of its last four games against the Atlantic Coast Conference.

Total Points Facts

  • Each of Syracuse’s last 13 games against non-Conference opponents at neutral venues have produced a total of 157 or fewer points.
  • Each of Iowa State’s last nine day games against non-AP-ranked opponents have produced a total of 151 or fewer points.

Matchup/League Facts

  • Iowa State ranks 7th among Division 1 teams for field goals made per game this season (33.5).
  • Iowa State ranks 8th among Division 1 teams for opponent turnovers per game this season (18.3).
  • Syracuse ranks 365th among Division 1 teams for free throw percentage this season (56.2%).
  • Syracuse ranks 3rd among Division 1 teams for opponent field goal percentage this season (34.1%).

Syracuse vs Iowa State Prediction


In this Syracuse vs Iowa State Prediction, Iowa State is coming as -9.5 road favorites. Iowa State has been the better team this season, being undefeated in its six games played, while Syracuse has lost its only road game. Both teams have been playing elite defense so far, ranking on the top-55 of the country and allowing just 125.8 points per game combined. As a result, they are 5-2 to the under in their last 7 games combined and I expect another low-scoring affair today. Take the under 157.5 points in this one.

Nikos Lagouretos's Pick: Under 157.5

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