Southern vs Iowa State Prediction 11/10/2026 Today’s College Basketball Picks

Southern vs Iowa State Prediction

I’ll stay with Iowa State. The Cyclones took a tough loss to a tricky Memphis team in their opener, shooting just 20 percent from three-point range (4-of-20) and 69 percent (22-of-32) from the line. Outside of that Iowa State played fairly well with just 11 turnovers and a competitive performance on the boards (a 38-36 deficit). The Cyclones looked much better in game two versus Southern Miss during a 26-point win. Iowa State shot 53 percent from the field with a 38-28 rebounding advantage and just 37 percent shooting allowed. The Cyclones did have a few more turnovers (15) however. Still, game three should be a highly manageable matchup for Iowa State.

As for Southern, they opened the season with a couple of tough games. First was a trip to SMU and a 13-point loss. In that one the Jaguars were great at the line (80 percent on 12-of-15) and didn’t shoot too badly on 44 percent. The 18 turnovers and 51 percent shooting allowed really hurt, though. In game two versus TCU, the Jaguars hit the wall in a blowout loss. Southern shot just 35 percent from the field in that one with 22 turnovers and a 43-30 rebounding deficit. As for game three against Drake, the Jags shot pretty well on 49 percent from the field and 43 percent (6-of-14) from outside. Southern was pretty competitive on the boards, but their Achilles heel came on 21 turnovers, which pretty much torpedoed their chances at their first win. The Jaguars need to get the ball control fixed or it’s going to be a long night.

Game Info, Stats and Previews

The Southern Jaguars and the Iowa State Cyclones meet Tuesday in college basketball action from Hilton Coliseum. Here’s a collection of relevant information and reasoning for a sound Southern vs Iowa State prediction. We have looked at this information from a betting perspective and attempted to determine the best Southern vs Iowa State pick. We will also examine the recent form and player performances for both teams, as well as the recent betting trends and streaks pertaining to this matchup. We will tie it all together to the pick summary, resulting in a sensible prediction for a favorable betting outcome in this game.

Southern Jaguars Betting Preview

The Jaguars have three games in the can so far this year. Southern opened up with a tough matchup at SMU’s Moody Coliseum in Dallas. The Jags ended up losing that one 85-72. Leading the way was R’Chaun King with 12 points and six rebounds in 23 minutes off the bench. As for game two, that one was another loss, this time 106-54 against TCU. In game three on Sunday versus Drake, the Jaguars took a 75-68 loss at Knapp Center in Des Moines to fall to 0-3 on the season so far.

Iowa State Cyclones Betting Preview

Over on the Iowa State side, they have two games in the bag so far and they’ve split the pair. The Cyclones had a tough matchup against a good Memphis team in their opener and ended up losing 80-76. Leading the team was Ryan Prather with 19 points in 27 minutes off the bench. Tamin Lipsey added 12 points with two rebounds and two assists.

Matched up against Southern Miss for game two at Hilton Coliseum, the Cyclones powered out a pretty easy 83-57 win. Iowa State’s Tre Singleton led the charge this time with 28 points and nine boards. Jaquan Johnson chipped in 10 points in 19 minutes of action off the bench during the win as well.

Southern Jaguars @ Iowa State Cyclones Betting Trends: November 10, 2026

Why the Iowa State Cyclones will win

• Iowa State has won each of its last 23 night games at James H. Hilton Coliseum against non-AP-ranked opponents.
• Southern has lost 25 of its last 26 road night games against non-Conference opponents.
• Southern has lost the first half in each of its last six road games against non-Conference opponents.

Andrew Jett's Pick: Iowa State Cyclones TBA