Florida State vs Clemson Prediction 2/21/2026 Today’s College Basketball Picks

The Florida State Seminoles and the Clemson Tigers meet Saturday in college basketball action from the Littlejohn Coliseum. We will look at this from a betting perspective and determine the best bets for this game. Here’s a Florida State Seminoles vs. Clemson Tigers prediction.

Florida State Seminoles Recap

The Florida State Seminoles come into this game looking to add on to their 80-72 win over Boston College last time out to sit at 13-13 this season. After this game, Florida State will head home for a game against Miami.

Seminoles Win 5 Of Last 6

Robert McCray V leads the Seminoles in scoring and assists with 14.4 PPG and 6.4 APG along with 3.6 RPG while Chauncey Wiggins has 12.5 PPG and 4 RPG. Lajae Jones has 11.3 PPG with 5.6 RPG and Koba MaGee has 10 PPG with 3.3 RPG to cap off the group of double-digit scorers for Florida State up to this point in the year. Martin Somerville has 8.9 PPG with 3 RPG and Alex Steen also has 7.2 PPG with a team-high 5.8 RPG to lead the Seminoles in rebounding this season. As a team, Florida State is averaging 80.8 PPG on 42.5% shooting from the field, 31.2% from three and 71.2% from the foul line this season.

Clemson Tigers Recap

The Clemson Tigers come into this game looking to bounce back from their 85-77 loss at the hands of Wake Forest last time out to sit at 20-7 this season. After this game, Clemson will take on Louisville at home.

Tigers Lose 3 In A Row

RJ Godfrey leads the Tigers in scoring with 11.6 PPG and 5.2 RPG while Carter Welling has 10.5 PPG with 5.7 RPG to lead Clemson in rebounding this season. Jestin Porter has 10 PPG to cap off the trio of double-digit scorers for Clemson so far this season. Dillon Hunter has 7.7 PPG with 4 RPG and 3 APG to lead the Tigers in assists. Nick Davidson has 9.5 PPG with 4 RPG and Ace Buckner has 7.8 PPG with 2.5 RPG. As a team, Clemson is averaging 74.8 PPG on 46.1% shooting from the field, 34.2% from three and 72.5% from the foul line this season.

Florida State Seminoles @ Clemson Tigers Betting Trends: February 21, 2026

Why the Clemson Tigers will win

• Clemson has won each of its last nine day games against non-AP-ranked opponents.
• Florida State has lost each of its last six games at Littlejohn Coliseum.
• Clemson has won the first half in each of its last five home day games against Conference opponents.

Why the Florida State Seminoles will win

• Florida State has won each of its last five games against non-AP-ranked opponents.
• Clemson has lost each of its last three games.
• Clemson has lost the first half in four of its last five games.

Total Points Facts

• Each of Clemson’s last nine day games have produced a total of 141 or fewer points.
• Each of Florida State’s last seven day games have produced a total of 154+ points.

Matchup/League Facts

• Clemson ranks 8th among Division 1 teams for opponent assists per game this season (10.3).
• Clemson ranks 14th among Division 1 teams for opponent field goals made per game this season (22.3).
• Florida State is one of only six teams to reach the Sweet 16 in each of its last three NCAA Tournament appearances.
• Florida State ranks 6th among Division 1 teams for three-point field goal attempts per game this season (32.4).

Florida State Seminoles vs. Clemson Tigers Prediction

I’m on Clemson here. I get the case to be made for Florida State who has been rolling as of late, but the problem here is that Clemson is in dire need of a bounce back showing and I’m not sure I trust the Noles to keep this one reasonable. I think Clemson can win this one by double-digits at home so give me the Tigers.

Chris Ruffolo's Pick: Clemson -8.5