Florida State vs Louisville Prediction 2/22/25 College Basketball Picks

The Florida State Seminoles are visiting the Louisville Cardinals on Saturday, February 22nd at the KFC Yum! Center. We will look at this from a betting perspective and determine the best bets for this game. Here’s a Florida State Seminoles vs Louisville Cardinals Prediction. We will examine:

The Louisville Cardinals’ recent form and player performance

The Florida State Seminoles’ recent form and player performance

Recent betting trends and streaks involving the Louisville Cardinals

Recent betting trends and streaks involving the Florida State Seminoles

Recent betting trends in games played between the Florida State Seminoles and Louisville Cardinals

A summary that ties it all together and produces a favorable betting outcome for the Florida State Seminoles vs Louisville Cardinals game

Louisville Cardinals Preview

The Louisville Cardinals have a 20-6 record this season and are sitting in second place in the ACC. Louisville is coming off a 76-50 win over Notre Dame. The Cardinals are 16-10 against the spread, and 9-17 in over/under while having a 10-3 home record. 

Offensively, Louisville is averaging 79.5 points per game, which ranks 55th in the nation. Defensively, they are allowing 69 points per game (93rd). The Cardinals shoot 45.1% from the field (168th) and 32.8% from beyond the arc (246th). The Cardinals shoot 73.7% from the free throw line (113th) and are grabbing 38.1 rebounds per game (56th).

Chucky Hepburn leads Louisville in scoring this season, with an average of 15 points, 3.4 rebounds, and a team-high 6.2 assists, while Terrence Edwards adds 14.8 points and 4 rebounds per game.

Florida State Seminoles Preview

The Florida State Seminoles have a 16-10 record this season and are sitting in 8th place in the Atlantic Coast. Florida State is coming off a 74-66 win over Miami. The Seminoles are 14-12 against the spread, and 10-15-1 in over/under, while having a 2-6 road record. 

Offensively, Florida State is averaging 75.3 points per game, which ranks 142nd in the nation. Defensively, they allow 70.7 points per game (148th). The Seminoles shoot 45.4% from the field (150th) and 31.4% from beyond the arc (310th). The Seminoles shoot 71.2% from the free-throw line (211th) and are grabbing 35.5 rebounds per game (175th).

Jamir Watkins leads Florida State in scoring this season, with an average of 17.9 points and 5.4 rebounds, while Malique Ewin adds 14.2 points and a team-high 8 rebounds per game.

Why the Louisville Cardinals will win

• Louisville has won each of its last 10 home games against non-AP-ranked opponents.
• Florida State has lost each of its last six games against AP-ranked opponents.
• Louisville has won the first half in each of its last 16 games against the Atlantic Coast Conference.

Why the Florida State Seminoles will win

• Louisville has lost eight of its last 10 day games against the Atlantic Coast Conference at KFC Yum! Center.
• Florida State has won four of its last five games at KFC Yum! Center.
• Louisville has lost the first half in eight of its last 10 day games against the Atlantic Coast Conference at KFC Yum! Center.

Total Points Facts

• Seven of Florida State’s last eight games against Conference opponents have produced a total of 149 or fewer points.
• Each of the last three games between Florida State and Louisville has produced a total of 159+ points.

Florida State Seminoles vs Louisville Cardinals Prediction

Florida State is 7-2 in their last 9 meetings against Louisville and is 6-3 against the spread. Over is 9-1 in their 10 meetings, and in their previous meeting earlier this season, Florida State won 90-76 on the road, not covering the spread, as the game went over the point total. 

In this Florida State Seminoles vs Louisville Cardinals Prediction, Louisville is coming as a -14.5 home favorites. Louisville is rightfully favored, as they have a better record this season, and have been extremely strong at home, while on the other hand, Florida State has been struggling on the road. the Cardinals are in very good form lately, as they are 9-1 in their last 10 games and 7-3 against the spread, while on the other hand, the Seminoles are 3-5 in their last 8 and 2-6 against the spread. The value here lies with the home team, so take the Louisville Cardinals and lay the points at home.