Vanderbilt vs South Carolina Prediction 9/13/2025 Today’s College Football Picks

In this article, we will formulate a Vanderbilt vs South Carolina Prediction for this College Football Week 3 game on Saturday, September 13th at the Williams-Brice Stadium. Let’s take a look at the prediction for this College Football matchup.

South Carolina Gamecocks Preview

The Gamecocks have a 2-0 record this season and are ranked as No.10 in the College Football Top 136 Team Rankings for 2025. Ohio State is number 1, Penn State is number 2 and LSU is number 3 in the rankings. South Carolina got outgained by their opponents by 270-253 yards. They had 11/20 completed passes, 128 passing yards, 125 rushing yards, with turnovers being 0-1. The Gamecocks went 3-12 in third down efficiency and had 7-48 penalties.

LaNorris Sellers had 11/19 passes, a team-high 128 passing yards, one touchdown and no interceptions. Jawarn Howell added a team-high 30 rushing yards, while Vandrevius Jacobs caught 4 passes for 57 yards. Defensively, DQ Smith had 6 total tackles, four of them solo, while Bryan Thomas Jr. had one sack. The Gamecocks did not record any interceptions in this game.

Vanderbilt Commodores Preview

The Commodores have a 2-0 record this season and are ranked as No.34 in the College Football Top 136 Team Rankings for 2025. Ohio State is number 1, Penn State is number 2 and LSU is number 3 in the rankings. Vanderbilt outgained their opponents by 490-248 yards. They had 14/20 completed passes, 228 passing yards, 262 rushing yards, with turnovers being 2-1. The Commodores went 5-7 in third down efficiency and had 11-77 penalties.

Diego Pavia had 12/18 passes, a team-high 193 passing yards, two touchdowns but also threw one interception. Makhilyn Young added a team-high 95 rushing yards, while Brycen Coleman caught 1 pass for 54 yards. Defensively, Nick Rinaldi had 6 total tackles, four of them solo, while Nick Rinaldi had one sack. The Commodores did not record any interceptions in this game.

Vanderbilt vs South Carolina Prediction

In their previous meeting last season, South Carolina won 28-7 on the road, covering the spread, as the game went under the point total. The Gamecocks have won their last 10 meetings against the Commodores, and are 8-1-1 against the spread. They have won their last five home meetings, and are 3-1-1 against the spread. Under is 7-3 in their last 10 meetings.

In this Vanderbilt vs South Carolina Prediction, South Carolina is coming in as -5.5-point home favorites, with the total set at 48 points. Both teams are a perfect 2-0 this season, with Vanderbilt’s offense looking superb so far, having scored 44 and 45 points. The Commodores are forced to play a second straight game on the road, while the Gamecocks are playing their third straight game of the season at their home court. South Carolina was a strong 5-2 at home last season and 9-3 against the spread, and haven’t lost by Vanderbilt since forever, so I like them as home favorites in this spot. Take the South Carolina Gamecocks and lay the points at home.

Nikos Lagouretos's Pick: South Carolina -4