Purdue vs Notre Dame Prediction 9/20/2025 Today’s College Football Picks

In this article we will formulate a Purdue vs Notre Dame prediction for this College Football game on Saturday, September 20th at Notre Dame Stadium in Notre Dame, Indiana. Let’s take a look at the prediction for this week 4 matchup. 

Purdue Boilermakers Betting Preview

The Purdue Boilermakers are 2-1 this year after they lost to USC by a score of 33-17 last week. Purdue trailed 3-0 after the first quarter and 17-3 at halftime, but they did score 14 points in the second half in the loss. The Boilermakers were out gained by a total of 460-357, went 7-14 on third downs, and lost the turnover battle by a total of 3-0 in the game. Ryan Browne went 24-39 for 305 yards, one touchdown, and three interceptions, while Devin Mockobee carried the ball 12 times for 45 yards. EJ Horton Jr caught five passes for 70 yards in the game. The Purdue defense recorded two sacks and seven tackles for loss in the defeat. 

Purdue started the season with a 31-0 win over Ball State in week one and a 34-17 win over Southern Illinois in week two. The Boilermakers are averaging 27.3 points per game with 271.7 passing yards and 119.7 rushing yards per game, while they are allowing 16.7 points against per game this season. Ryan Browne has completed 63.6% of his passes for 786 yards, five touchdowns, and four interceptions, while Arhmad Branch has caught seven passes for 167 yards and two scores. Devin Mockobee is the leading rusher with 58 carries for 230 yards and three touchdowns this year. 

Notre Dame Fighting Irish Betting Preview

The Notre Dame Fighting Irish are 0-2 this season after they lost to Texas A&M by a score of 41-40 last week. Notre Dame led 14-7 after the first quarter, but they trailed 28-24 at the half. The Fighting Irish went back and fourth with A&M in the second half, but they missed a late extra point and lost with 13 seconds left. Notre Dame was out gained by a total of 488-440, went 7-15 on third downs, and tied the turnover battle at one. CJ Carr went 20-32 for 293 yards, one touchdown, and one interception, while Jeremiyah Love rushed 23 times for 94 yards and one score. Eli Raridon caught four passes for 85 yards in the loss. The ND defense recorded zero sacks and just two tackles for loss in the game. 

Notre Dame lost to Miami to open their season by a score of 27-24 in week one. The Fighting Irish are averaging 32.0 points per game with 257.0 passing yards and 114.5 rushing yards per game, while they are allowing 34.0 points against per game on defense this season. CJ Carr has completed 62.9% of his passes for 514 yards, three touchdowns, and two interceptions, while Eli Raridon has caught nine passes for 182 yards. Jeremiyah Love has led the rushing attack with 33 carries for 127 yards and one score this season. 

Why Notre Dame will beat Purdue 

Purdue has lost each of its last 10 games against AP-ranked teams.
Notre Dame has won each of its last seven games against non-AP-ranked teams.
Notre Dame has covered the spread in each of its last five games as a favorite against non-AP-ranked teams.
Purdue has failed to cover the spread in each of its last four games as an underdog against AP-ranked teams.

Total Points Facts

Each of Notre Dame’s last four games against opponents from the Big Ten Conference at Notre Dame Stadium have gone UNDER the total points line.
Five of Purdue’s last six September games as an underdog against AP-ranked teams have gone UNDER the total points line.

Matchup/League Facts

Notre Dame ranks 135th among FBS teams for Q2 opponent points per game this season (17.5).
Notre Dame ranks T132nd among FBS teams for average point differential in second quarters this season (-9.0).
Purdue ranks T116th among FBS teams for red zone percentage this season (66.7).
Purdue ranks T24th among FBS teams for 4th down conversion percentage this season (83.3).

David Racey is 16-9 (64%) in his last 25 College Football plays this season. Click here for his premium plays for this week!

Purdue vs Notre Dame Prediction 

Notre Dame has started the season with two losses to two ranked teams, which has put them on the ropes early in the year. The Fighting Irish cannot afford anymore losses if they want to make the College Football Playoff, so I expect a dominant effort here. Purdue was actually competitive with USC last weekend, but they are still a work in progress and go against a very good defense here. Just because ND has lost two games in a row, doesn’t mean they are bad, as they are still probably one of the better teams in the country. Take Notre Dame to win big here.