Ohio vs South Alabama Prediction 9/19/2026 Today’s College Football Picks

The Ohio Bobcats and the South Alabama Jaguars meet Saturday in college football action from Hancock Whitney Stadium in Mobile. Here’s an Ohio vs South Alabama prediction. We will look at this from a betting perspective and determine the best Ohio vs South Alabama pick. We will examine the recent form and player performances for both teams, as well as the recent betting trends and streaks pertaining to this matchup. As we conclude, we will tie it all together with a summary that produces a sensible pick for a favorable betting outcome in this game.

Ohio Bobcats Betting Preview

Ohio caught Nebraska off guard early in their opener, exiting the first quarter with a 10-7 lead. The Bobcats added a field goal in the second and trailed by a point at halftime but eventually lost 49-21. Nick Poulos was 14-of-31 for 164 yards and a TD while also leading the rush on 10 carries for 70 yards and another score. Riley Neer caught six balls for 104 yards and one TD.

In the Jacksonville State game, the Bobcats scored 10 points in the fourth quarter to force overtime. Following four extra periods, Ohio eventually emerged victorious on a tight 29-27 finish. Matt Vezza did most of the quarterbacking this time with 10-of-12 passing, 80 yards and a TD. Vezza also led the rush with 12 carries for 67 yards but Duncan Brune added 66 yards on 18 carries.

South Alabama Jaguars Betting Preview

Over on the South Alabama side, they kicked off their season with a matchup versus Southeastern Louisiana. The Jaguars managed to put up points in every quarter during that game, taking the win in dominant fashion 39-14. Bishop Davenport was 18-of-27 passing for 154 yards and a TD, and PJ Martin led the rushing attack on 69 yards and a TD off 18 totes.

Matched up against Tulane last weekend, the Jags had an early lead 10-0 after the first quarter. South Alabama traded punches in the second half but it wasn’t enough in a 28-24 loss. Davenport was 22-of-32 this time for 296 yards and two scores. Martin was tops in rushing once again for South Alabama, notching 73 yards and a TD on 15 carries.

Ohio Bobcats @ South Alabama Jaguars Betting Trends: Week 3

South Alabama Jaguars Player Prop Facts

• Heading into Week 3, Keenan Phillips ranks 10th amongst FBS players for kick return yards (117) this season.

Ohio Bobcats Player Prop Facts

• Heading into Week 3, DJ Hamilton is one of only five players in the FBS to have a kick return touchdown this season.

Matchup/League Facts

• South Alabama ranks 11th among FBS teams for Q1 points per game this season (14.5).
• South Alabama ranks T16th among FBS teams for 1st downs against this season (24).
• Ohio ranks T1st among FBS teams for red zone percentage this season (100.0).
• Ohio ranks T134th among FBS teams for average point differential in third quarters this season (-10.5).

Ohio vs South Alabama Prediction

I’ll stay with South Alabama. The Jags were able to rack up 478 total yards (182 rushing) in their tight loss to Tulane with 6.6 yards per play, 25 first downs and 10-of-16 on third-down tries. The defense gave up 424 yards (212 passing) and 8.3 yards per play but only 13 first downs. Tulane held the ball for just 22:20 as well.
As for Ohio, they get credit for gutting out a marathon of a game and getting the win over Jacksonville State last weekend. The Bobcats had just 97 passing yards and 4.0 yards per play on offense. The D surrendered 447 total yards, 6.2 yards per play, 22 first downs and 9-of-15 on third-down tries. This could be a pretty good matchup if both teams play well but I’ve got the Jags on a slight advantage cover-wise.

Andrew Jett's Pick: South Alabama Jaguars -4.5