Mississippi State vs South Carolina Prediction 9/19/2026 Today’s College Football Picks

The Mississippi State Bulldogs and South Carolina Gamecocks meet Saturday in week 3 college football action at Williams-Brice Stadium. Here’s a Mississippi State vs. South Carolina Prediction. This article will include a Mississippi State vs. South Carolina Pick.

Mississippi State Bulldogs Betting Preview 

The Mississippi State Bulldogs beat UL Monroe and Minnesota, and they play Missouri next. Mississippi State has lost 8 of its last 11 games. Kamario Taylor is completing 67.9 percent of his passes for 581 yards, 7 touchdowns, and 0 interceptions. Anthony Evans III and Marquis Johnson have combined for 346 receiving yards and 3 touchdowns, while Zion Ragins has 6 receptions. 

The Mississippi State Bulldogs’ ground game is averaging 298.5 yards per contest, and Fluff Bothwell leads the way with 165 yards and 2 touchdowns. On defense, Mississippi State allows 13 points and 285 yards per game. Jalen Smith leads the Mississippi State Bulldogs with 12 tackles, Trevion Williams has 1 sack, and Kelley Jones has 2 pass deflections.

South Carolina Gamecocks Betting Preview 

The South Carolina Gamecocks beat Kent State and Towson, and will play Alabama next. The South Carolina Gamecocks look to start 3-0 for the first time since the 2012 season. LaNorris Sellers is completing 63 percent of his passes for 366 yards, 3 touchdowns, and 1 interception. Nyck Harbor and Donovan Murph have combined for 197 receiving yards and 2 touchdowns, while DJ Black has 3 receptions. 

The South Carolina Gamecocks’ ground game averages 341.5 yards per contest, and Matt Fuller leads with 199 yards and 2 touchdowns. On defense, South Carolina allows 4.5 points and 191 yards per game. Andrew Harris leads the South Carolina Gamecocks with 22 tackles, J’Zavien Currence has 1 sack, and Quay’sheed Scott has 2 pass deflections.
Why the South Carolina Gamecocks will win

• South Carolina has won 17 of its last 18 September games as a favorite against non-AP-ranked teams.
• Mississippi State has lost nine of its last 10 road games against conference opponents.
• Mississippi State has failed to cover the spread in each of its last three games against conference opponents.
• South Carolina has covered the spread in three of its last four games in September.
• Mississippi State has lost the first half in 13 of its last 14 road games against conference opponents.

Why the Mississippi State Bulldogs will win

• South Carolina has lost each of its last five games against conference opponents.
• Mississippi State has won five of its last six games in September.
• Mississippi State has covered the spread in each of its last four September games as an underdog.
• South Carolina has lost the first half in three of its last four home games against conference opponents.

Total Points Facts

• Six of Mississippi State’s last seven road games in September have gone UNDER the total points line.

South Carolina Gamecocks Player Prop Facts

• Heading into Week 3, Jabree Coleman ranks T11th amongst FBS players for rushing touchdowns (3) this season.

Mississippi State Bulldogs Player Prop Facts

• Heading into Week 3, Kamario Taylor ranks 10th amongst qualified players for passer rating (196.3) this season.

Matchup/League Facts

• South Carolina ranks T1st among FBS teams for Q4 opponent points per game this season (0.0).
• South Carolina ranks T2nd among FBS teams for H1 opponent points per game this season (1.5).
• Mississippi State ranks 2nd among FBS teams for yards per game this season (620.5).
• Mississippi State ranks T4th among FBS teams for Q1 points per game this season (17.5).

Mississippi State vs South Carolina Prediction

Mississippi State has had the tougher schedule up to this point, but it’s tough to play back-to-back road games against respectable opponents. South Carolina has also been imrpvoed defensively up to this point and has a quarterback who could be in for a turnaround season. Remember, it wasn’t that long ago that Sellers was in Heisman talks and was a first-round NFL draft pick. This is a big season for the Gamecocks. Statement game. The line isn’t anything crazy. I’ll lay the points with South Carolina at home, as I like the upside of this team.

Randy Chambers's Pick: South Carolina -4