Cardinals vs Rams Prediction 10/18/2026 Today’s NFL Picks

In this article we will formulate a Cardinals vs Rams prediction for this NFL game on Sunday, October 18th at SoFi Stadium in Inglewood, California. Let’s take a look at the prediction for this week 6 matchup.

Arizona Cardinals Betting Preview

The Arizona Cardinals are 1-4 this season after they lost to the Lions by a score of 45-21 in their last game. Arizona led 7-0 after the first quarter, but they allowed the next 31 points and never recovered in the lopsided loss. The Cardinals were out gained by a total of 412-327, went 8-18 on third downs, and lost the turnover battle by a total of 1-0 in the game. Jacoby Brissett threw for 292 yards, three touchdowns, and one interception, while Kendrick Bourne caught five passes for 70 yards. Jeremiyah Love had 12 carries for 22 yards in the loss.

Prior to that game, Arizona lost to the Giants by a score of 36-24 and the 49ers by a score of 36-30. The Cardinals have scored 21.6 points per game with 209.6 passing yards and 92.6 rushing yards per game, while they have allowed 32.4 points against per game this season. Jacoby Brissett has thrown for 1,110 yards with nine touchdowns and five interceptions this season.

Los Angeles Rams Betting Preview

The Los Angeles Rams are 2-3 this year after they lost to the Bills by a score of 37-34 in overtime on Monday night. Los Angeles trailed 13-7 at halftime, but they scored with five seconds left to force overtime, where they lost on a field goal. The Rams out gained Buffalo by a total of 454-436, went 7-14 on third downs, and won the turnover battle by a total of 2-0 in the game. Matthew Stafford threw for 383 yards and three touchdowns, while Puka Nacua caught 17 passes for 138 yards and one score. Kyren Williams rushed 16 times for 49 yards and one touchdown in the game.

Prior to that loss, Los Angeles defeated the Eagles by a score of 24-20, but lost to the Broncos by a score of 30-26 before that. The Rams have scored 23.8 points per game with 307.6 passing yards and 116.8 rushing yards per game, while they have allowed 24.0 points against per game this season. Matthew Stafford has thrown for 1,572 yards with nine touchdowns and six interceptions this year.

Why the Los Angeles Rams will win

• The Cardinals have lost each of their last 10 games against NFC opponents.
• The Rams have won each of their last 11 day games against teams that held a losing record.
• The Rams have covered the spread in each of their last eight Sunday day games against teams that held a losing record.
• The Cardinals have failed to cover the spread in each of their last four Sunday games against teams that held a losing record.
• The Rams have won the first half in each of their last four games as favorites against the Cardinals.

Why the Arizona Cardinals will win

• The Rams have lost three of their last four October games as home favorites.
• The Cardinals have won three of their last five games as underdogs when playing with a rest advantage.
• The Rams have failed to cover the spread in each of their last four games when playing with a rest disadvantage.
• The Cardinals have covered the spread in five of their last six games in California.
• The Cardinals have won the first half in four of their last five Sunday day games at SoFi Stadium.
• The Cardinals have won the first quarter in each of their last two October games as underdogs against NFC opponents.

Total Points Facts

• Seven of the Rams’ last eight Sunday games have gone OVER the total points line.
• Seven of the Cardinals’ last eight games in October have gone OVER the total points line.
• Each of the last three Sunday day games at SoFi Stadium have gone UNDER the total points line.

Los Angeles Rams Player Prop Facts

• Davante Adams has scored the first touchdown in three of his last four appearances in California.
• Davante Adams has scored two touchdowns in three of his last four appearances in California.
• Kyren Williams has scored the last touchdown in each of the Rams’ last three October games as favorites against NFC opponents.
• Blake Corum has recorded 45+ rushing yards in seven of the Rams’ last eight day games against NFC opponents.
• Tyler Higbee has recorded 36+ receiving yards in seven of his last eight home appearances in games with a total points line of at least 50.0.
• Matthew Stafford has recorded 317+ passing yards in each of the Rams’ last four games as favorites.
• Matthew Stafford has recorded 24+ completions in each of the Rams’ last seven home games as heavy favorites (>-7.0 points).
• Kyren Williams has scored at least one touchdown in each of his last six October home appearances.
• Puka Nacua has recorded 100+ rushing and receiving yards in each of his last six appearances on the West Coast.
• Heading into Week 6, Matthew Stafford has recorded the most completions in a single game this season (40 vs Bills, Week 5).

Arizona Cardinals Player Prop Facts

• Jacoby Brissett has recorded 27+ completions in four of the Cardinals’ last five games following a home loss.
• Jacoby Brissett has recorded 10+ rushing yards in eight of his last nine October appearances.
• Jacoby Brissett has recorded 249+ passing yards in six of the Cardinals’ last seven games as underdogs following a home loss.
• Trey McBride has recorded 65+ receiving yards in each of the Cardinals’ last eight Sunday day games as road underdogs.
• Kendrick Bourne has recorded 38+ rushing and receiving yards in each of his last six appearances with his team as an underdog in games with a total points line of at least 50.0.
• James Conner has scored at least one touchdown in each of his last seven appearances in day games against teams that held a losing record.
• Heading into Week 6, Jacoby Brissett has thrown the equal-most interceptions in a single game this season (3 vs Giants, Week 4).

Matchup/League Facts

• Rams – five different players have recorded 70+ receiving yards in a game this season – equal-most in the NFL, heading into Week 6.
• Rams – four different players have recorded 80+ receiving yards in a game this season – equal-most in the NFL, heading into Week 6.
• Heading into Week 6, the Cardinals rank 32nd in the NFL in average point differential in third quarters this season (-4.2).
• Heading into Week 6, the Cardinals rank 32nd in the NFL in average points against in third quarters this season (9.0).

Cardinals vs Rams Prediction

Arizona comes into this matchup on a four game losing streak and they have allowed 31+ points in all four games. The Cardinals are 1-2 on the road, while the Rams are 1-2 at home. Los Angeles has alternated wins and losses over their first five games, but their defense has had some struggles so far this year. The Rams have allowed 27+ points in three of their five games, so Arizona may have some chances to move the ball. Take the over in this contest.

David Racey's Pick: Over 51.5