Cleveland Cavaliers vs Indiana Pacers Prediction 4/10/25 NBA Picks

Cleveland Cavaliers Betting Preview 

The Cleveland Cavaliers have been in great shape as they've won seven of their last nine games overall, and they will be eager to keep it going after making light work of the Bulls in a 135-113 home win on Tuesday. Darius Garland led the team with 28 points and five assists, Evan Mobley added 21 points with 12 rebounds and seven assists, while Ty Jerome chipped in with 18 points off the bench. As a team, the Cavaliers shot 51 percent from the field and a sizzling 25 of 50 from the 3-point line as they caught fire early. They never looked in any danger after exploding for 43 points in the second quarter to take a 20-point lead into halftime. The Cavs will take on the Knicks after this game.

Indiana Pacers Betting Preview 

Meanwhile, the Indiana Pacers have been on a tear as they've won 11 of their last 13 games overall, and they will be gunning for a sixth-straight victory after sneaking past the Wizards in a 104-98 home win on Tuesday. Pascal Siakam led the team with 24 points, 10 rebounds, and three assists; Tyrese Haliburton added 22 points with six assists, while Myles Turner chipped in with 14 points, 11 rebounds, and five blocks. As a team, the Pacers shot 37 percent and nine of 35 from the 3-point line, which aren't great numbers at all. But they made up for it on the defensive end as they held the Wizards to just 13 points in the second quarter to overcome an early 16-point deficit. They finished with a flurry in the fourth to escape with the narrow win. 

Why the Indiana Pacers will win

• The Pacers have won each of their last seven home games against Eastern Conference opponents.
• The Cavaliers have lost seven of their last eight games as underdogs following a home win.
• The Cavaliers have failed to cover the spread in five of their last six road games against opponents who are on the first leg of a back-to-back.
• The Pacers have covered the spread in seven of their last eight Thursday games against Central Division opponents that held a winning record.

Why the Cleveland Cavaliers will win

• The Cavaliers have won 12 of their last 13 road games following a win.
• The Pacers have lost 10 of their last 12 games against Cavaliers teams that held a winning record.
• The Pacers have failed to cover the spread in each of their last seven games as favorites against Eastern Conference opponents following a win.
• The Cavaliers have covered the spread in each of their last six games as road underdogs against Eastern Conference opponents.

Cleveland Cavaliers vs Indiana Pacers Prediction

The Cavaliers are going to be missing some players with Donovan Mitchell, Darius Garland, and Evan Mobley all ruled out, while the Pacers are keeping an eye on Ben Sheppard, who is questionable. The Cavaliers are still piling on the wins, but they are more interested in getting to the playoffs healthy at this point, so it's not surprising to see them resting players. With that being said, the Pacers still have plenty to play for, and I can't see them missing out on such a good chance to beat the Cavaliers. The line is a bit hefty, but I think the Pacers do enough to get the win and cover at home in a high-scoring affair.