Tigers vs Guardians Prediction 9/25/2025 Today’s MLB Picks

In this article we will formulate a Tigers vs Guardians prediction for this MLB game on Thursday, September 25th at Progressive Field in Cleveland, Ohio. Let’s take a look at the prediction for this MLB matchup. 

Detroit Tigers Betting Preview

The Detroit Tigers are 85-73 this season after they lost the first two games in this series by scores of 2-5 and 1-5. In their game two loss, Detroit led 1-0 in the third inning, but couldn’t score over the last six innings for the loss. The Tigers recorded six hits and they committed two errors in the game, while they were led by Meadows, who went 0-2 with one RBI in the loss. Detroit started Flaherty, who allowed five hits and three earned runs over 4.1 innings for the loss, while four pitchers combined to close out the game. 

Prior to this series, the Tigers lost all three against the Braves and all three against the Guardians. Detroit has lost 11 of their last 12 games and they are second in the AL Central standings. The Detroit pitching staff has a 3.97 ERA with a 1.25 WHIP and a .242 opponent batting average, while the offense has scored 746 runs with a .247 batting average and a .316 on base percentage this season. Riley Greene has led Detroit with 35 home runs and 110 RBIs, while Spencer Torkelson has added 31 home runs and 78 RBIs this year. The projected starting pitcher for Detroit is TBD. 

Cleveland Guardians Betting Preview

The Cleveland Guardians are 86-72 this year after they won game two by a score of 5-1 on Wednesday night. Cleveland took a 2-1 lead in the third inning and added three more insurance runs to seal the victory. The Guardians recorded eight hits in the game and they were led by Valera and Ramirez, who both had two RBIs in the win. Cleveland started Bibee, who allowed five hits and one earned run over 6.0 innings for the win, while Herrin and Gaddis picked up holds. 

Prior to this series, the Guardians won three out of four against the Twins and all three against the Tigers. Cleveland has won 12 of their last 13 games and they are now first in the AL Central standings. The Cleveland pitching staff has a 3.68 ERA with a 1.26 WHIP and a .239 opponent batting average, while the offense has scored 626 runs with a .226 batting average and a .297 on base percentage this season. Jose Ramirez has led Cleveland with 30 home runs and 84 RBIs, while Kyle Manzardo has added 26 home runs and 68 RBIs this year. The projected starting pitcher for Cleveland is Parker Messick, who is 3-0 with a 2.08 ERA and a 1.30 WHIP over 34.2 innings pitched this year. 

Why the Guardians will beat the Tigers 

The Guardians have won each of their last nine night games against American League opponents.
The Tigers have lost each of their last seven games following a loss.
The Guardians have covered the run line in each of their last 11 night games following a win.
The Tigers have failed to cover the run line in each of their last seven games following a loss.
The Tigers have trailed after 5 innings in four of their last five games.

Total Runs Facts

Twelve of the Guardians’ last 13 games after playing the previous day have gone UNDER the total runs line.
Four of the Tigers’ last five road games against American League opponents have gone OVER the total runs line.
The ‘Inning 1 UNDER 0.5 runs’ market has hit in eight of the last nine games between the Tigers and Guardians.
The ‘Inning 1 UNDER 0.5 runs’ market has hit in each of the Tigers’ last five games against American League opponents.

Cleveland Guardians Player Prop Facts

Lane Thomas has hit a home run in three of his last seven appearances in night games.
Jose Ramirez has recorded at least one hit in each of the Guardians’ last seven games against AL Central opponents.

Detroit Tigers Player Prop Facts

Riley Greene has hit a home run in two of the Tigers’ last three games at Progressive Field.
Spencer Torkelson has recorded at least one hit in 11 of his last 12 road appearances against the Guardians after playing the previous day.

Tigers vs Guardians Prediction 

Cleveland comes into this matchup continuing to stack wins, as they are starting to pull away in the AL Central standings. The Guardians are 43-34 at home this year, while the Tigers are 39-38 on the road. Detroit is in an absolute free fall right now and they look like they couldn’t care less out there, as they are in danger of missing the playoffs. Detroit has not named a starter for this game, which isn’t great, as their pitching staff and bullpen have been awful. Cleveland is going with Messick, who has allowed two earned runs or fewer in four of his last five starts. It is tough to gauge this matchup without knowing who is pitching for Detroit, but I don’t see how you can take the Tigers here. Back the Guardians to win.