Arizona Diamondbacks vs Minnesota Twins Prediction 9/13/2025 Today’s MLB Picks

The Arizona Diamondbacks and the Minnesota Twins meet Saturday in MLB action from Target Field. We will look at this from a betting perspective and determine the best bets for this game. Here’s an Arizona Diamondbacks vs. Minnesota Twins prediction.

Starting Pitching Matchup

The Arizona Diamondbacks will send out Ryne Nelson for the start here and Nelson is 7-3 with a 3.48 ERA and 118 strikeouts this season. In his career, Nelson is 0-2 with a 16.20 ERA and 8 strikeouts against the Twins. Joe Ryan will get the nod for the Twins and is 13-8 with a 3.32 ERA and 176 strikeouts this season. This will be Ryan’s second career start against the Diamondbacks.

Arizona Diamondbacks Recap

The Arizona Diamondbacks come into this game looking to rebound from a 9-8 loss at the hands of the Twins in Friday’s series opener to drop to 73-75 this season. After this series, the Diamondbacks will make the trip home for a series rematch with the San Francisco Giants.

Diamondbacks Drop 4 Of Last 5

Corbin Carroll has 131 hits with 30 home runs, 74 RBIs, 16 triples and 29 doubles this season. Carroll also has a team-high 26 stolen bases and Geraldo Perdomo has 24 stolen bases as well as 17 home runs and 91 RBIs with a team-high 151 hits this season. Ketel Marte’s added 25 home runs and 64 RBIs as well on the year and Lourdes Gurriel has 124 hits with 24 doubles, 19 home runs and 80 RBIs.

Minnesota Twins Recap

The Minnesota Twins come into this game looking to add on to their win over the Diamondbacks from Friday’s clash to improve to 65-82 this season. After this series, the Twins will welcome the New York Yankees to town for a series.

Twins Trying To Play Spoiler

Byron Buxton has 116 hits along with 18 doubles, a team-high 30 home runs and 74 RBIs with 22 stolen bases and 7 triples while Trevor Larnach’s chipped in 117 hits with 20 doubles, 16 home runs and 57 RBIs as well this season. Brooks Lee has contributed 104 hits with 14 doubles, 14 home runs and 57 RBIs and Matt Wallner has 21 homers and 39 RBIs as well. 

Arizona Diamondbacks @ Minnesota Twins Betting Trends: September 13, 2025

• Probable Starting Pitcher: Joe Ryan      Record this season: 13-8      ERA: 3.32
• Home Record: 7-4
• Last 5 against Diamondbacks: 0-0

Why the Minnesota Twins will win

• The Twins have won each of their last nine home games against the Diamondbacks.
• The Diamondbacks have lost each of their last six road games against the Twins following a loss.
• The Diamondbacks have failed to cover the run line in seven of their last eight games against AL Central opponents.
• The Twins have covered the run line in each of their last five games against the Diamondbacks following a home win.
• The Diamondbacks have trailed after 5 innings in seven of their last eight games against AL Central opponents.

• Probable Starting Pitcher: Ryne Nelson      Record this season: 7-3      ERA: 3.48
• Road Record: 2-2
• Last 5 against Twins: 0-2

Why the Arizona Diamondbacks will win

• The Twins have lost each of their last six games as favorites after playing the previous day.
• The Diamondbacks have won five of their last six games as underdogs against American League opponents.
• The underdogs have covered the run line in each of the Twins’ last 11 games.
• The Twins have failed to cover the run line each of their last eight home games against teams that held a losing record.
• The Diamondbacks have led after 5 innings in four of their last five games against American League opponents.
• The Diamondbacks have won the first inning in six of their last seven night games against opponents that held a losing record.
• The Diamondbacks have led after 3 innings in four of their last five games against American League opponents.

Total Runs Facts

• Eight of the Twins’ last nine home games have gone OVER the total runs line.
• Each of the Diamondbacks’ last five games as underdogs against the Twins have gone OVER the total runs line.
• The ‘Inning 1 UNDER 0.5 runs’ market has hit in each of the Twins’ last eight Saturday games against NL West opponents.
• The ‘Inning 1 OVER 0.5 runs’ market has hit in six of the Diamondbacks’ last seven road games against AL Central opponents.

Minnesota Twins Player Prop Facts

• Joe Ryan has recorded a win in each of his five previous home appearances against NL West opponents.
• Joe Ryan has recorded six or more strikeouts in each of his last four appearances against NL West opponents.
• Ryan Jeffers has hit at least one home run in three of his last four appearances with the Twins as favorites against the Diamondbacks.
• Ryan Jeffers has recorded a Double in each of his last three appearances in night games against NL West teams that held a losing record.
• Ryan Jeffers has recorded at least one hit in each of his last six appearances with the Twins as favorites against NL opponents.
• Byron Buxton ranks 4th amongst qualified players for Slugging Percentage (.565) this season.

Arizona Diamondbacks Player Prop Facts

• Geraldo Perdomo has hit a home run in three of the Diamondbacks’ last four road games against AL opponents.
• Ryne Nelson has recorded five or more strikeouts in each of his last three appearances against AL Central opponents.
• Gabriel Moreno has recorded at least one hit in each of his last 12 appearances in night games against teams that held a losing record.
• Corbin Carroll ranks 6th amongst qualified players for Slugging Percentage (.546) this season.

Matchup/League Facts

• The Twins rank 3rd in the league for walks allowed this season (419).
• The Twins rank 27th in the league for opponent batting average this season (.260).
• The Diamondbacks rank T1st in the league for triples this season (35).
• The Diamondbacks rank 2nd in the league for RBIs this season (712).

Arizona Diamondbacks vs. Minnesota Twins Prediction

I’m on the Diamondbacks here. I still think that Arizona is just the far superior batting lineup offensively especially after all of the offloading that Minnesota did at the trade deadline. I know that the Twins won’t lose every game, and Ryan is still supposed to be Minnesota’s ace, but he’s been shaky at best as of late and I think Arizona gets some revenge here. Give me the Diamondbacks here.