Cleveland Guardians vs San Diego Padres Prediction 4/2/25 MLB Picks

San Diego Padres (6-0) vs Cleveland Guardians (2-3)

Game Info: Wednesday, April 2, 2025 at 4:10 pm (Petco Park)

B. Lively (R) vs D. Cease (R)

Betting Odds: San Diego Padres -185 / Cleveland Guardians +154 --- Over/Under: 7.5 Click Here for the Latest Odds

Where to Watch: MLB.TV

In this article, we will formulate a Cleveland Guardians vs San Diego Padres Prediction for this MLB game on Wednesday, April 3rd, at Petco Park. To formulate this prediction, we will look at: 

-The Guardians’ recent form and recent player performance 

-The Padres’ recent form and recent player performance

-Recent Betting trends and streaks involving Cleveland

-Recent Betting trends and streaks involving San Diego

-Recent betting trends in games played between Cleveland and San Diego

-A summary that ties it all together produces a favorable betting outcome for Today’s Game between the Guardians and Padres. 

Guardians Bats….BRRRR

The Guardians' bats are suddenly ice cold, and over the last two games, they have scored only two runs. On Tuesday against the Padres, the Guardians had as many errors as hits, sitting at two. Logan Allen was on the mound for Cleveland, and he went 5.1 innings, giving up seven hits and four runs. He also allowed five walks. It’s been pretty simple this year for the Guardians. When the offense has been good, they have found success; when they have struggled, the offense hasn’t gotten anything going. 

The Guardians are averaging 3.6 runs per game, while their pitching is giving up 4.8 runs per game. Their offense is ranked 20th in the league, and they need to find a way to get it going here. Ben Lively will start for the Guardians, and he has a 0-0 record and an ERA of 5.40. Against the Kansas City Royals, he went five innings, giving up four hits and three runs. 

Why the Guardians Will Beat the Padres

  • The Padres have lost each of their last four Wednesday day games as home favorites against AL Central opponents.
  • The Guardians have won three of their last four day games following a loss.
  • The Padres have failed to cover the run line each of their last six Wednesday day games against American League opponents that held a losing record.
  • The Guardians have covered the run line in four of their last five day games following a loss.

What a Start for the Padres

The season has just started, but the Padres have been quite impressive, and they currently sit with a 6-0 record. On Tuesday, the pitching was dominant, and the Padres scored seven runs on the way to the victory. Fernando Tatis Jr. didn’t even have a hit but still ended up with one run, two walks, and two RBIs. Over the last five games, the Padres have given up only five runs in total. The pitching has just been so dominant, and it looks like they are going to be really hard to beat this season. Michael King went five innings, giving up two hits and zero runs and striking out 11 in total. 

Dylan Cease will start for the Padres. He has a 0-0 record and an ERA of 6.23. Against the Atlanta Braves, he pitched 4.1 innings, giving up four hits and three runs. He is one of the only pitchers who hasn’t been a bright spot. 

Cleveland Guardians vs San Diego Padres Prediction

We all know the Padres aren’t going to 162-0, and at some point, they have to pick up their first loss. There is no better time for this to happen than Wednesday. Dylan Cease wasn’t the brightest spot against an Atlanta Braves offense that hasn’t been good. The Guardians' offense hasn’t been great either, but they are going to break out in a big way here. Trusting Ben Lively for the Cubs might be a sweat also, but the Guardians' offense is going to be what ends up being too much here. Back the Guardians on the money line to cash here. 

Shane’s Pick Guardians ML

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The pick in this article is the opinion of the writer, not a PickDawgz site consensus.

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