Indiana State vs Southern Illinois Prediction 2/25/2026 Today’s College Basketball Picks

The Indiana State Sycamores and the Southern Illinois Salukis meet Wednesday in college basketball action from SIU Arena in Carbondale. Here’s an Indiana State vs Southern Illinois prediction. We will look at this from a betting perspective and determine the best Indiana State vs Southern Illinois pick. We will examine the recent form and player performances for both teams, as well as the recent betting trends and streaks pertaining to this matchup. As we conclude, we will tie it all together with a summary that produces a sensible pick for a favorable betting outcome in this game.

Indiana State Sycamores Betting Preview

Indiana State got through their first 11 games this year on a pretty nice 7-4 run. Losses to Bradley, Illinois State, Northern Iowa, Drake, Evansville, Murray State, Bradley, Drake, UIC and Valparaiso came over the next nine games though. The Sycamores then beat Evansville before losses to Southern Illinois, Murray State, Valparaiso, Northern Iowa and Belmont.

In the Belmont game on Saturday the Sycamores were in trouble at haft lime on a 39-25 disadvantage. Indiana State got outscored 48-45 the rest of the way and ended up losing the game 87-70 in a road matchup. The Sycamores’ Ian Scott topped the team on 16 points with 11 rebounds for a double-double and Sterling Young had 14 points with one assist. Camp Wagner added 14 points with three assists as well.

Southern Illinois Salukis Betting Preview

Over on the Southern Illinois side, they limped their way through the first 20 games on a rough 8-12 clip. The Salukis have since clawed back near .500 though, beating Northern Iowa, Illinois State, Indiana State, Evansville, Drake and Northern Iowa during a 6-3 stretch over the last nine games. That gives the Salukis a 14-15 overall record through the first 29 games of the year.

In the Northern Iowa game on Saturday the Salukis went off the floor in the first half with a 33-30 advantage. Southern Illinois was outscored 27-26 the rest of the way, resulting in a 59-57 victory away from home. Quel’Ron House was tops on 21 points with five assists and four rebounds. Drew Steffe had 14 points with three assists and two rebounds in the victory.

Indiana State Sycamores @ Southern Illinois Salukis Betting Trends: February 25, 2026

Why the Southern Illinois Salukis will win

• Indiana State has lost 10 of its last 11 games against non-AP-ranked opponents.
• Southern Illinois has won four of its last five games against non-AP-ranked opponents.
• Southern Illinois has won the first half in eight of its last 10 home night games against the Missouri Valley Conference.

Why the Indiana State Sycamores will win

• The road team has won each of Southern Illinois’ last three games.
• Southern Illinois has lost three of its last four home games against non-AP-ranked opponents.

Indiana State vs Southern Illinois Prediction

I’ll lean toward Southern Illinois. The Salukis beat a pretty good Northern Iowa team in a road matchup last weekend, hitting 51 percent from the field with a 27-20 rebounding advantage. Southern Illinois got to the line just three times (making one) however, and coughed up 16 turnovers along the way. Still, the Salukis are now 6-3 in the last nine games and 4-1 in their last five.

Back on February 9 when these teams last met up the Salukis took an 80-65 road victory. Southern Illinois shot 46.5 percent from the field in that one with a 40-29 rebounding edge and a 52-34 advantage on points in the paint. The Salukis had turnover trouble (12) in that one as well, so I’d like to see a single-digit number in the rematch.

Andrew Jett's Pick: Southern Illinois Salukis -8.5