Butler vs DePaul Prediction 3/7/2026 Today’s College Basketball Picks

The Butler Bulldogs and the DePaul Blue Demons meet Saturday in college basketball action from Wintrust Arena in Chicago. Here’s a Butler vs DePaul prediction. We will look at this from a betting perspective and determine the best Butler vs DePaul pick. We will examine the recent form and player performances for both teams, as well as the recent betting trends and streaks pertaining to this matchup. As we conclude, we will tie it all together with a summary that produces a sensible pick for a favorable betting outcome in this game.

Butler Bulldogs Betting Preview

The Bulldogs were just 10-7 back in mid-January then hit a win streak versus Seton Hall, DePaul and Marquette. Losses to St. John’s, Georgetown, Providence, Marquette, UConn and Seton Hall came next, then wins over Georgetown and Xavier. After another loss to Villanova, the Bulldogs had a 15-14 record in the books over the first 29 games for their troubles.

On Wednesday versus Creighton the Bulldogs were sitting in the locker room with a 36-32 advantage on the scoreboard. After emerging for the second half Butler went on a 44-23 defat the rest of the way and lost the game in the end 76-59. Leading the team in scoring during the futile effort was Michael Ajayi with 26 points, 13 rebounds and three assists in 39 minutes.

DePaul Blue Demons Betting Preview

Over on the DePaul side, they were 12-8 over their first 20 games of the season. The Blue Demons lost to Georgetown, Xavier, St. John’s and Providence in the next four, but then hit a 4-1 run over the next five. Those wins came courtesy of Creighton, Seton Hall, Creighton again and Marquette. That would give DePaul a 16-13 record across their first 29 games this year.

Matched up against Villanova on Wednesday the Demons were within two points at the break, trailing 26-24. DePaul got blasted in the second half on a 50-33 deficit, eventually taking the loss on their home court 76-57 in the end. Brandon Maclin was tops on the team with 16 points, five rebounds and four assists while NJ Benson added 11 points with five rebounds.

Butler Bulldogs @ DePaul Blue Demons Betting Trends: March 7, 2026

Why the DePaul Blue Demons will win

• DePaul has won each of its last five day games at Wintrust Arena against non-AP-ranked opponents.
• Butler has lost eight of its last 10 games against Conference opponents.

Why the Butler Bulldogs will win

• Butler has won 23 of its last 24 games against DePaul.
• DePaul has lost 22 of its last 27 day games against the Big East Conference.
• Butler has won the first half in each of its last five day games against DePaul.

Butler vs DePaul Prediction

I’ll lean toward DePaul. The Blue Demons need a good bounce-back effort here after falling in blowout fashion versus a good Villanova team this week, though. In that one DePaul shot 43.1 percent from the field and just 12.5 percent (2-of-16) from outside along with a 33-23 rebounding deficit and 15 turnovers for 22 Wildcats points. The Demons are still a pretty solid 4-2 in their last six games, but they’ve only scored a combined 119 points in their last pair.

Back on January 20 when these teams last met up, DePaul took an 87-80 loss on the road. In that one the Demons shot just 41.3 percent from the field while giving up 56.9 percent shooting on defense. DePaul did have a mild rebounding advantage (26-25) and got eight steals on 12 Bulldogs turnovers but weren’t very good in the paint with a 34-26 deficit. I like the Blue Demons to play better in the home rematch though.

Andrew Jett's Pick: DePaul Blue Demons -2.5